Transpupillary Thermotherapy Threshold Parameters

Peyman, Gholam A.; Genaidy, Mahmoud; Yoneya, Shin; Men, Gamze; Ghahramani, F; Kuo, Po-Cheng; Bezerra, Yanno; Nishiyama-Ito, Yoko; Moshfeghi, Andrew A

doi:10.1097/00006982-200306000-00015

Cited by 13 publications

(7 citation statements)

References 46 publications

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“…Pigmented rabbit is a well-established animal model for retinal laser therapy [9,12,[15][16][17], which provides conservative estimation of the damage thresholds compared to human eye. Retinal photocoagulation thresholds with 532 and 577nm wavelengths in rabbits are about 2.5 times lower than in humans [18,19].…”

Section: Discussionmentioning

confidence: 99%

Retinal safety of near infrared radiation in photovoltaic restoration of sight

Lorach

Wang

Lee

et al. 2015

Biomed. Opt. Express

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Photovoltaic restoration of sight requires intense near-infrared light to effectively stimulate retinal neurons. We assess the retinal safety of such radiation with and without the retinal implant. Retinal damage threshold was determined in pigmented rabbits exposed to 880nm laser radiation. The 50% probability (ED50) of retinal damage during 100s exposures with 1.2mm diameter beam occurred at 175mW, corresponding to a modeled temperature rise of 12.5°C. With the implant, the same temperature was reached at 78mW, close to the experimental ED50 of 71mW. In typical use conditions, the retinal temperature rise is not expected to exceed 0.43°C, well within the safety limits for chronic use.

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Section: Discussionmentioning

confidence: 99%

Retinal safety of near infrared radiation in photovoltaic restoration of sight

Lorach

Wang

Lee

et al. 2015

Biomed. Opt. Express

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“…The main aim behind the use of ICG in these situations would be to make the tumor tissue containing ICG more sensitive to the thermal therapy delivered by the infrared lasers. Moreover, ICG may allow the desired clinical endpoint with reduced laser parameters [6]. …”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported enhanced laser-tumor tissue photothermal interaction between the diode laser used in TTT (810 nm) and indocyanine green (ICG) dye and showed that ICG could decrease the laser fluence and irradiance threshold in TTT photocoagulation properties [5,6]. As a result, this treatment has been used in other ocular conditions such as ocular melanoma and choroidal neovascularization [7,8].…”

Section: Introductionmentioning

confidence: 99%

Indocyanine Green-Enhanced Thermotherapy for Retinoblastoma

et al. 2014

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Purpose: To report the outcome of pediatric patients with retinoblastoma refractory to traditional local therapy who were treated with indocyanine green (ICG)-enhanced thermotherapy. Materials and Methods: This is a retrospective review of a case series of 3 patients with bilateral retinoblastoma who were treated with ICG-enhanced thermotherapy after showing no response to conventional chemothermotherapy or transpupillary thermotherapy (TTT) alone noted on two consecutive examinations under anesthesia. Results: The 3 patients had had one eye enucleated previously due to advanced disease, and the remaining eye was diagnosed with a large tumor, which showed either a marginal or no response to systemic chemotherapy and TTT. Addition of ICG enhancement during the subsequent TTT session shrunk the tumor to a measurable size that could then be followed by TTT alone as a means of treatment. One patient had tumor recurrence, at which time additional TTT without ICG was successfully applied after the tumor size had decreased; ICG enhancement was then added whenever TTT alone provided no response. Conclusions: ICG enhancement with TTT led to a measurable tumor regression in lesions that had previously not been responsive to traditional chemothermotherapy or isolated TTT. Message: These tumors had shown a minimal to no response to previous TTT treatment. However, adding ICG resulted in a measurable regression even though the same TTT treatment parameters were applied. © 2014 S. Karger AG, Basel

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“…The histologic damage can be noted in the neurosensory retina even at threshold lesions, without retinal whitening (29,30). One variation of TTT involves the use of indocyanine green dye (ICG) as a thermal enhancing agent during treatment (31)(32)(33)(34)(35). Because the absorption peak of ICG dye (805 nm) is similar to the wavelength of the diode laser emission peak (810 nm), ICG dye enhances the laser photocoagulation effect, permitting use of a lower energy level than is possible without it.…”

Section: Introductionmentioning

confidence: 99%

“…The selective ablation of CNV should result in less damage to the surrounding tissues. Peyman and colleagues (34) demonstrated that by combining TTT with intravenous ICG pretreatment, the synergy resulted in a much lower TTT threshold fluence and irradiance required to create angiographically visible lesions in the normal rabbit choriocapillaris. They demonstrated a dose-dependent relationship between TTT fluence threshold and ICG concentration, with higher ICG concentration correlating to lower TTT fluence threshold.…”

Section: Introductionmentioning

confidence: 99%

Regression of Peripapillary Choroidal Neovascularization after Oscillatory Transpupillary Thermotherapy and Anti-VEGF Pharmacotherapy

Peyman

Tsipursky

Gohel

et al. 2010

European Journal of Ophthalmology

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Indocyanine green-assisted OTT has the potential to treat CNV in wet age-related macular degeneration. It may reduce thermal side effects and eliminate or reduce the need for frequent intravitreal treatment. We postulate that I-OTT has a synergistic effect of thermal energy combined with a weak photosensitizer (ICG) applied in an individualized manner, which minimizes thermal damage to retinal and choroidal tissue. Additional anti-vascular endothelial growth factor pharmacotherapy enhances the effect of I-OTT on abnormal new vessels.

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Transpupillary Thermotherapy Threshold Parameters

Cited by 13 publications

References 46 publications

Retinal safety of near infrared radiation in photovoltaic restoration of sight

Retinal safety of near infrared radiation in photovoltaic restoration of sight

Indocyanine Green-Enhanced Thermotherapy for Retinoblastoma

Regression of Peripapillary Choroidal Neovascularization after Oscillatory Transpupillary Thermotherapy and Anti-VEGF Pharmacotherapy

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