The prevalence of radial access for transradial catheterization remains low in the US, occurring in only 28% of cases in the National Cardiovascular Data Registry (NCDR®) CathPCI®. It is unknown whether the low adoption rate has been influenced by patient characteristics, or is more operator dependent. In a 10-center study, we compared clinical and demographic characteristics among 323 radial and 1506 femoral access PCIs performed by 65 interventionists capable of radial percutaneous intervention (PCI). We created a hierarchical logistic regression model to identify operator and patient characteristics associated with radial PCI and the median rate ratio to quantify the variation across operators. A subset was interviewed to assess health literacy and preferences in shared medical decision-making. Radial access was used in 17.7% of patients. Patient factors associated with lower rate of radial PCI were prior PCI (33.4% vs 41.4% P=0.008), history of Coronary Artery Bypass Graft (8.4% vs 23.0% P <0.001) and Chronic Total Occlusion PCI (10.2% vs 17.9% P <0.001). Operator characteristics associated with lower rate of radial PCI are being older, being longer in practice, lower number of publications and Southern practice location. The range of radial use across operators was 1– 99% and the median rate ratio was 1.97. Patients with radial access had lower health literacy, as assessed by the REALM score (6.6±2.6 vs 7.1±2.0, p= 0.03) but did not differ in their preferences for shared decision-making. In conclusion our study demonstrates a high degree of variability of radial access for PCI among different operators, with few differences in patient characteristics, suggesting that improvement efforts should focus on operators.