Transsphenoidal hypophysectomy as a treatment for Rathke's cleft cyst in a dog

Blokland‐Post, Krista van; Grinwis, Guy C. M.; Tellegen, Anna R.; Meij, Björn P.

doi:10.1002/vrc2.427

Cited by 3 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cysts within the pituitary gland are a rare entity and there is only one reported Radke's cleft cyst in the veterinary literature. These cysts may cause a non-functional enlargement of the pituitary gland and may only present with clinical signs after severe enlargement causes central nervous signs ( 44 ) or as an obstruction of the nasopharynx (personal data).…”

Section: Discussionmentioning

confidence: 99%

Challenges of transsphenoidal pituitary surgery in severe brachycephalic dogs

et al. 2023

View full text Add to dashboard Cite

IntroductionTranssphenoidal hypophysectomy is the standard surgical technique for the excision of pituitary neoplasms. Anatomy may be more obscured in brachycephalic skull types due to the crowding of soft tissue and osseous structures. We describe the unique challenges to approach the sphenoid bone and localize the correct burr hole site in severe brachycephalic dogs.Materials and methodsA single institution retrospective case series of brachycephalic dogs with pituitary-dependent hypercortisolism (PDH). Preoperative computed tomography enabled 3D-, and cross-sectional reconstruction to plan and dry-practice the position of the ideal burr hole in relation to the sella turcica, pterygoid hamular processes, and hard palate. Rostral burring of the caudal hard palate obscuring the direct sphenoid approach necessitated adaptations to the original transsphenoidal hypophysectomy procedure. Postoperative outcomes and complications with respect to those seen in mesocephalic dogs are described.ResultsTen brachycephalic dogs including French Bulldogs (n = 9) and a single Dogue de Bordeaux were included. All dogs were diagnosed with PDH and had preoperative advanced imaging performed on the skull. All but one dog had an enlarged pituitary gland, with a median pituitary/brain value of 0.5 (range 0.21–0.9). A total of 11 transsphenoidal hypophysectomy procedures were performed in these 10 dogs. Rostral extension of the soft palate incision into the hard palate was performed to access the burr hole site on the sphenoid bone. Major complications included aspiration pneumonia (n = 1), severe gastroesophageal reflux (n = 1), and central nervous signs (=1). All dogs survived until discharge, with a median time to follow-up of 618 days (range 79–1,669 days). Seven dogs experienced long-term remission of PDH.ConclusionBrachycephalic dogs undergoing transsphenoid al hypophysectomy benefit from meticulous presurgical planning and extension of the approach into the caudal hard palate. Advanced surgical skills can render a good outcome in a technically challenging environment.

show abstract

Section: Discussionmentioning

confidence: 99%

Challenges of transsphenoidal pituitary surgery in severe brachycephalic dogs

et al. 2023

View full text Add to dashboard Cite

show abstract

Transsphenoidal Surgery for Pituitary Tumors

Meij,

van Stee

2025

Veterinary Clinics of North America: Small Animal Practice

View full text Add to dashboard Cite

Dorsomedian nasopharyngeal masses with benign appearance in dogs: A retrospective medical review of 95 cases among 198 dogs (2019‐2022)

Petitpre,

Deprez,

Cervone

et al. 2024

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundDorsomedian nasopharyngeal masses with benign macroscopic appearance are frequently observed during retrograde nasopharyngoscopy, particularly in brachycephalic breeds, but are not well described.Hypothesis/ObjectivesTo characterize these masses, assess their frequency, and identify the potential factors associated with their presence.AnimalsDogs that underwent retrograde nasopharyngoscopy at a private hospital.MethodsMedical records between November 2019 and October 2022 were retrospectively reviewed. Dogs were included if suitable nasopharynx images were available for review. Univariable and multivariable logistic regression analyses were performed to determine the factors associated with these masses.ResultsOne‐hundred ninety‐eight dogs met the inclusion criteria of which 47.9% (95/198) had a dorsal nasopharyngeal mass. The masses measured <10%, 10%‐30%, and >30% of the nasopharyngeal height in 64.2% (61/95), 28.4% (27/95), and 7.4% (7/95) of cases, respectively. Univariable analysis identified associations between the presence of a nasopharyngeal mass and several factors: brachycephalic conformation (P < .001), sleep disturbances (P = .04), presence of laryngeal collapse (P = .01), and aberrant caudal turbinates (P = .04). However, according to the multivariable analysis, only the association between the presence of a mass and brachycephalic conformation was significant (odds ratio = 2.3 [1.1; 5.0], P = .03).Conclusion and Clinical ImportanceDorsomedian nasopharyngeal masses were common in the studied dog population. These masses are mostly small and have the same appearance across breeds. Brachycephalic conformation appears to be associated with the presence of a mass.

show abstract

Transsphenoidal hypophysectomy as a treatment for Rathke's cleft cyst in a dog

Cited by 3 publications

References 19 publications

Challenges of transsphenoidal pituitary surgery in severe brachycephalic dogs

Challenges of transsphenoidal pituitary surgery in severe brachycephalic dogs

Transsphenoidal Surgery for Pituitary Tumors

Dorsomedian nasopharyngeal masses with benign appearance in dogs: A retrospective medical review of 95 cases among 198 dogs (2019‐2022)

Contact Info

Product

Resources

About