Transsphenoidale Hypophysektomie bei einer Patientin mit einem ACTH-produzierenden Hypophysenadenom und einer »empty Sella« nach Vorbehandlung mit Etomidat

Herrmann, Benedikt; Mitchell, Antonine Pineau; Saller, Bernhard; Stolke, D.; Forsting, Michael; Frilling, Andrea; Mann, Klaus

doi:10.1055/s-2001-11477

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…There have been a number of case reports on the successful use of etomidate in controlling hypercortisolemia in seriously ill patients with CD even in the pediatric population 46–48…”

Section: Medical Management Of CDmentioning

confidence: 99%

Treatment of Cushing disease: overview and recent findings

Giustina¹

2010

TCRM

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Endogenous Cushing syndrome is an endocrine disease caused by excessive secretion of adrenocorticotropin hormone in approximately 80% of cases, usually by a pituitary corticotroph adenoma (Cushing disease [CD]). It is a heterogeneous disorder requiring a multidisciplinary and individualized approach to patient management. The goals of treatment of CD include the reversal of clinical features, the normalization of biochemical changes with minimal morbidity, and long-term control without recurrence. Generally, the treatment of choice is the surgical removal of the pituitary tumor by transsphenoidal approach, performed by an experienced surgeon. Considering the high recurrence rate, other treatments should be considered. Second-line treatments include more radical surgery, radiation therapy, medical therapy, and bilateral adrenalectomy. Drug treatment has been targeted at the hypothalamic or pituitary level, at the adrenal gland, and also at the glucocorticoid receptor level. Frequently, medical therapy is performed before surgery to reduce the complications of the procedure, reducing the effects of severe hypercortisolism. Commonly, in patients in whom surgery has failed, medical management is often essential to reduce or normalize the hypercortisolemia, and should be attempted before bilateral adrenalectomy is considered. Medical therapy can be also useful in patients with CD while waiting for pituitary radiotherapy to take effect, which can take up to 10 years or more. So far, results of medical treatment of CD have not been particularly relevant; however, newer tools promise to change this scenario. The aim of this review is to analyze the results and experiences with old and new medical treatments of CD and to reevaluate medical therapies for complications of CD and hypopituitarism in patients with cured CD.

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“…There have been a number of case reports on the successful use of etomidate in controlling hypercortisolemia in seriously ill patients with CD even in the pediatric population 46–48…”

Section: Medical Management Of CDmentioning

confidence: 99%

Treatment of Cushing disease: overview and recent findings

Giustina¹

2010

TCRM

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“…Etomidate has been used for short-term control of hypercortisolemia in severely ill patients with Cushing's syndrome [200][201][202] and ectopic ACTH syndrome [203,204]. It is a useful drug when a rapid control of cortisol levels in patients with severe hypercortisolaemia and life-threatening complications is needed.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Pharmacological Therapy of Cushings Syndrome: Drugs and Indications

Díez

Iglesias²

2007

MRMC

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Current Awareness

2001

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 19 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Transsphenoidale Hypophysektomie bei einer Patientin mit einem ACTH-produzierenden Hypophysenadenom und einer »empty Sella« nach Vorbehandlung mit Etomidat

Cited by 10 publications

References 9 publications

Treatment of Cushing disease: overview and recent findings

Treatment of Cushing disease: overview and recent findings

Pharmacological Therapy of Cushings Syndrome: Drugs and Indications

Current Awareness

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