Transthoracic echocardiographic measurement of coronary artery diameter: Validation against quantitative coronary angiography☆☆☆★

Hildick‐Smith, David; Shapiro, Leonard M.

doi:10.1016/s0894-7317(98)70009-4

Cited by 15 publications

(9 citation statements)

References 31 publications

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“…The fact that certain parts of the coronary arteries can be visualized with TTE has been recognized for several years (32). 2D TTE has been used to study the LM (25,32), the proximal LAD (21,23,31), as well as the middle and distal LAD (10,12,13,16,26). In previous studies, the measurements of distal LAD diameter by TTE and QCA provided highly similar results (13) and a good correlation was shown between measurements of middle LAD diameter by epicardial echocardiography and TTE (11).…”

Section: Discussionmentioning

confidence: 82%

“…Previously, good agreement has been demonstrated between coronary artery diameter measurements by TTE and quantitative coronary angiography (QCA) (13) or epicardial echocardiography (16) in the middle or distal segments of the LAD. However, the suitability of TTE for assessment of diameter of other coronary arteries has not been systematically validated.…”

mentioning

confidence: 97%

“…IT HAS BEEN SHOWN that transthoracic echocardiography (TTE), which is noninvasive and widely used in clinical practice, can be used to visualize the left main artery (LM) (25,32) and left anterior descending coronary artery (LAD) (9,13,16,21,23,26,31). It has been possible to detect stenoses and aneurysms of these coronary arteries by changes of arterial lumen diameter with the use of TTE (23,25,31,32).…”

mentioning

confidence: 99%

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Coronary artery diameter can be assessed reliably with transthoracic echocardiography

Kiviniemi¹,

Saraste²,

Koskenvuo³

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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We studied whether diameters of coronary arteries can be measured accurately with the use of transthoracic echocardiography (TTE). By knowing the anatomic diameter of the coronary artery together with coronary flow velocity it is possible to measure coronary flow volume more precisely by TTE. However, the suitability of TTE for measurement of diameters of all main epicardial coronary arteries has not been systematically validated. We measured the diameters of the left main (LM), left anterior descending (LAD), left circumflex (LCX), and right coronary arteries (RCA) with the use of TTE [manual two-dimensional (2D), color-Doppler, and automated 2D analysis] in 30 patients who had normal coronary anatomy. We compared these diameters to those measured with quantitative coronary angiography (QCA). We could measure diameters of LM, LAD, LCX, and RCA by TTE in up to 37%, 63%, 7%, and 60% of patients, respectively. The overall correlation coefficients between TTE and QCA measurements were 0.83 (P < 0.01) with manual 2D analysis, 0.82 (P < 0.01) with automated 2D analysis, and 0.94 (P < 0.01) with a color-Doppler-based analysis. Interobserver variability of TTE measurements was low (coefficient of variation 5.4 +/- 4.6-7.5 +/- 8.8%). TTE is an accurate method to evaluate coronary artery diameter in patients with healthy coronary arteries.

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Section: Discussionmentioning

confidence: 82%

mentioning

confidence: 97%

mentioning

confidence: 99%

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Coronary artery diameter can be assessed reliably with transthoracic echocardiography

Kiviniemi¹,

Saraste²,

Koskenvuo³

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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“…30 57 58 This success rate reflects the youth and lean upper body mass of the athletes, which made them ideal echocardiographic subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Distal LAD diameter was measured at end diastole with internal calipers applied to endothelial borders; therefore intraluminal diameter was gauged as previously validated 30. Peak velocities were read with spectrum calipers.…”

Section: Methodsmentioning

confidence: 99%

Coronary flow reserve is supranormal in endurance athletes: an adenosine transthoracic echocardiographic study

Hildick‐Smith

Johnson

Wisbey

et al. 2000

Heart

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Objective-To compare coronary flow reserve in endurance athletes and healthy sedentary controls, using adenosine transthoracic echocardiography. Methods-29 male endurance athletes (mean (SD) age 27.3 (6.6) years, body mass index (BMI) 22.1 (1.9) kg/m 2 ) and 23 male controls (age 27.2 (6.1) years, BMI 23.9 (2.6) kg/m 2 ) with no coronary risk factors underwent transthoracic echocardiographic assessment of distal left anterior descending coronary artery (LAD) diameter and flow, both at rest and during intravenous adenosine infusion (140 µg/kg/min). Results-Distal LAD diameter and flow were adequately assessed in 19 controls (83%) and 26 athletes (90%). Distal LAD diameter in athletes (2.04 (0.25) mm) was not significantly greater than in sedentary controls (1.97 (0.27) mm). Per cent increase in LAD diameter following 400 µg sublingual nitrate was greater in the athletes than in the controls, at 14.1 (7.2)% v 8.8 (5.7)% (p < 0.01). Left ventricular mass index in athletes exceeded that of controls, at 130 (19) v 98 (14) g/m 2 (p < 0.01). Resting flow among the athletes (10.6 (3.1) ml/min; 4.4 (1.2) ml/min/100 g left ventricular mass) was less than in the controls (14.3 (3.6) ml/min; 8.2 (2.2) ml/min/100 g left ventricular mass) (both p < 0.01). Hyperaemic flow among the athletes (61.9 (17.8) ml/min) exceeded that of the controls (51.1 (14.6) ml/min; p = 0.02), but not when corrected for left ventricular mass (25.9 (5.6) v 28.5 (7.4) ml/min/100 g left ventricular mass; NS). Coronary flow reserve was therefore substantially greater in the athletes than in the controls, at 5.9 (1.0) v 3.7 (0.7) (p < 0.01). Conclusions-Coronary flow reserve in endurance athletes is supranormal and endothelium independent vasodilatation is enhanced. Myocardial hypertrophy per se does not necessarily impair coronary flow reserve. Adenosine transthoracic echocardiography is a promising technique for the investigation of coronary flow reserve. (Heart 2000;84:383-389)

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eG Coated Stents Exhibit Enhanced Endothelial Wound Healing Characteristics

Rodriguez-Garcia

Bureau²,

Barakat

2021

Cardiovasc Eng Tech

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Purpose Despite their widespread use, a significant fraction of coronary stents suffer from in-stent restenosis and stent thrombosis. Stent deployment induces extensive injury to the vascular endothelium. Rapid endothelial wound closure is essential for the success of a stenting procedure. A recent study has demonstrated that the BuMA Supreme® sirolimus-eluting stent exhibits particularly attractive strut coverage characteristics. A unique feature of this stent is the presence of a thin brush layer of poly-butyl methacrylate (PBMA), covalently bonded to the stent’s cobalt-chromium frame via electro-grafting (eG™). The present study aimed to determine whether the PBMA coating has an effect on endothelial cell wound healing and stent strut coverage. Methods We used an in vitro coronary artery model whose wall consisted of an annular collagen hydrogel and whose luminal surface was lined with a monolayer of endothelial cells. Mechanical wounding of the endothelial lining was preformed prior to deployment of a bare cobalt-chromium stent either with or without the PBMA layer. The migration of fluorescently labeled endothelial cells was monitored automatically over a period of 48 h to determine endothelial wound healing rates. Results Quantitative assessment of endothelial wound healing rates within the simulated arterial model is achievable using automated image analysis. Wound healing is significantly faster (44% faster at 48 h) for stents with the PBMA eG Coating™ compared to bare metal stents. Conclusion The PBMA eG Coating™ has the effect of promoting endothelial wound healing. Future studies will focus on elucidating the mechanistic basis of this observation.

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Transthoracic echocardiographic measurement of coronary artery diameter: Validation against quantitative coronary angiography☆☆☆★

Cited by 15 publications

References 31 publications

Coronary artery diameter can be assessed reliably with transthoracic echocardiography

Coronary artery diameter can be assessed reliably with transthoracic echocardiography

Coronary flow reserve is supranormal in endurance athletes: an adenosine transthoracic echocardiographic study

eG Coated Stents Exhibit Enhanced Endothelial Wound Healing Characteristics

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