Transthoracic ultrasound shear wave elastography for the study of subpleural lung lesions

Abstract

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Sono-Elastography: An Ultrasound Quantitative Non-Invasive Measurement to Guide Bacterial Pneumonia Diagnosis in Children

“…Quarato et al [30] studied a total of 190 adult SWE patients with subpleural lesions and found no statistical differences in the shear wave velocities or their extrapolation to Young's modulus between lung carcinomas, lung metastases or pneumonias. In a similar line of research, Ozgokce et al [41] and Wei et al [42] found different results for the sensitivity and specificity of diagnosing malignant subpleural lesions by SWE, although they selected different cut-off values.…”

“…Some research teams have worked on the approach to certain subpleural lesions or interstitial conditions by SE [38][39][40]. Quarato et al [30] studied a total of 190 adult SWE patients with subpleural lesions and found no statistical differences in the shear wave velocities or their extrapolation to Young's modulus between lung carcinomas, lung metastases or pneumonias. In a similar line of research, Ozgokce et al [41] and Wei et al [42] found different results for the sensitivity and specificity of diagnosing malignant subpleural lesions by SWE, although they With this background, the aim of the present study is to assess whether transthoracic lung SWE may represent a new quantitative method suitable for the assessment of pulmonary consolidations.…”

“…The SWE device detects and measures, in real time, the propagation speed of this transverse shear wave, which is related to the elasticity of the tissue, so that the greater the stiffness of the tissue, the greater the speed of the wave. The quantitative value of the stiffness is obtained by converting the shear wave velocity (m/s) into Young’s modulus (kPa) using the relationship E = 3ρcs, where ρ is the tissue density and cs is the velocity [ 29 , 30 ]. The current shear-wave SE modalities are: 1D-Transient elastography (Fibroscan TM ) : This is based on the generation of an external vibration (50 Hz) that is transmitted from the body surface to the target tissue, where compression is produced.…”

Lung ultrasound in a nutshell. Lines, signs, some applications, and misconceptions from a radiologist’s point of view. Part 2

“…The results of their study are presented in Figure 2 . On the other hand, in the study of Quarato et al ., surprisingly, non-necrotic pneumonias had higher elasticity than carcinomas [ 10 ]. An interesting observation from their study was the statistically significant difference between community-acquired pneumonia and pneumonia refractory to standard treatment, with the latter producing greater elasticity values (mean 30.45 ± 11.78 kPa vs. 19.40 ± 6.45 kPa), probably due to fibrotic component in chronicity.…”

Thoracic Ultrasound Strain Elastosonography as a Noninvasive Biomarker of Chronic Obstructive Pulmonary Disease-Associated Lung Injury: A Feasibility Study

“…In spite of this, SWE and SE are increasingly being studied in the field of respiratory medicine. Apart from application of SWE during endobronchial ultrasoundguided transbronchial needle aspiration procedures for differentiating malignant versus nonmalignant consolidations and mediastinal and hilar lymph nodes [5][6][7][8][9], transthoracic SWE was also shown to be of potential utility in discriminating between subpleural malignant lesions from nonmalignant consolidations [10][11][12]. Furthermore, the pioneering studies by Zhang and colleagues [13] have shown that the lung tissue, despite its low density and very high acoustic impedance, can generate surface-wave propagation at the lung-pleura interface that can be reliably and reproducibly measured by elastosonography in both healthy subjects [13] and patients with interstitial lung disease [14][15][16].…”