Transthyretin in cerebrospinal fluid from suicide attempters

Transthyretin as a potential CSF biomarker for Alzheimer’s disease and dementia with Lewy bodies: effects of treatment with cholinesterase inhibitors

“…Therefore, it was postulated that the low levels of TTR resulted in reduced levels of thyroid hormones being distributed throughout the brain and CSF, which could lead to thyroid hormone‐related depression [8]. In a previous study using CSF from depressed patients after an actual suicide attempt, we found no differences in CSF TTR compared to other psychiatric diagnoses or controls [25]. However, in the same study, we found a significant correlation between CSF TTR and the item ‘failing memory’ assessed using the Comprehensive Psychopathology Rating Scale [26], which could be interpreted as a relationship between CSF TTR and cognitive impairment [25].…”

“…In a previous study using CSF from depressed patients after an actual suicide attempt, we found no differences in CSF TTR compared to other psychiatric diagnoses or controls [25]. However, in the same study, we found a significant correlation between CSF TTR and the item ‘failing memory’ assessed using the Comprehensive Psychopathology Rating Scale [26], which could be interpreted as a relationship between CSF TTR and cognitive impairment [25]. However, in the present study, no relationship was found between CSF TTR and severity of cognitive impairment in AD and DLB as assessed with the MMSE.…”

Transthyretin—A Key Gene Involved in Regulating Learning and Memory in Brain, and Providing Neuroprotection in Alzheimer Disease via Neuronal Synthesis of Transthyretin Protein

“…However, it is unclear whether TTR affects the clearance of β-amyloid from the CSF [10]. In vitro studies showed that TTR via its TGB interacts with Aβ residues, preventing its toxicity in the brain cells [12] [13] [14] [15]. TTR is suggested to be a protease molecule with apolipoprotein structure A-I (apoA-I) and Aβ as substrates.…”