Transtympanic iontophoresis of gadopentetate dimeglumine: preliminary results

Christodoulou, Panayiotis; Doxas, Panagiotis G.; Papadakis, Chariton E.; Prassopoulos, Panos; Maris, Thomas G.; Helidonis, Emmanuel S.

doi:10.1016/s0194-5998(03)00713-7

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…However, currently available approaches for ME drug delivery rely upon injection through the membrane as the most effective methodology. Other attempts at trans-tympanic drug deliver have employed invasive and noninvasive approaches like passive diffusion aided by hydrogels 42 , nanoparticles 43 , chemical additives 44 or surfactants 45 , and physical iontophoresis 46 to increase membrane permeability. These techniques have had limited efficacy clinically due to the low ME concentration of drug molecules achieved, and inability to assist large molecule transit.…”

Section: Discussionmentioning

confidence: 99%

Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear

Kurabi

Pak

Bernhardt

et al. 2016

Sci Rep

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Otitis media (OM) is a common pediatric disease for which systemic antibiotics are often prescribed. While local treatment would avoid the systemic treatment side-effects, the tympanic membrane (TM) represents an impenetrable barrier unless surgically breached. We hypothesized that the TM might harbor innate biological mechanisms that could mediate trans-TM transport. We used two M13-bacteriophage display biopanning strategies to search for mediators of trans-TM transport. First, aliquots of linear phage library displaying 1010th 12mer peptides were applied on the TM of rats with active bacterial OM. The middle ear (ME) contents were then harvested, amplified and the preparation re-applied for additional rounds. Second, the same naïve library was sequentially screened for phage exhibiting TM binding, internalization and then transit. Results revealed a novel set of peptides that transit across the TM to the ME in a time and temperature dependent manner. The peptides with highest transport capacities shared sequence similarities. Historically, the TM was viewed as an impermeable barrier. However, our studies reveal that it is possible to translocate peptide-linked small particles across the TM. This is the first comprehensive biopanning for the isolation of TM transiting peptidic ligands. The identified mechanism offers a new drug delivery platform into the ME.

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Section: Discussionmentioning

confidence: 99%

Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear

Kurabi

Pak

Bernhardt

et al. 2016

Sci Rep

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“…In traditional drug delivery, MRI has been used to assist intraparenchymal injections and to obtain three-dimensional (3D) data on the distributions in organs and tissues (18). Iontophoretic drug delivery to the tympanic membrane and middle and inner ear has also been examined using MRI (19,20). In addition, MRI has been used in vaginal drug-delivery studies to determine the distribution of a vaginal gel and the effects of, for example, its volume on distribution by loading the gel with a contrast agent (21).…”

Section: Introductionmentioning

confidence: 99%

MRI in ocular drug delivery

Lizak

Jeong

2008

NMR in Biomedicine

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Conventional pharmacokinetic methods for studying ocular drug delivery are invasive and cannot be conveniently applied to humans. The advancement of MRI technology has provided new opportunities in ocular drug-delivery research. MRI provides a means to non-invasively and continuously monitor ocular drug-delivery systems with a contrast agent or compound labeled with a contrast agent. It is a useful technique in pharmacokinetic studies, evaluation of drug-delivery methods, and drug-delivery device testing. Although the current status of the technology presents some major challenges to pharmaceutical research using MRI, it has a lot of potential. In the past decade, MRI has been used to examine ocular drug delivery via the subconjunctival route, intravitreal injection, intrascleral injection to the suprachoroidal space, episcleral and intravitreal implants, periocular injections, and ocular iontophoresis. In this review, the advantages and limitations of MRI in the study of ocular drug delivery are discussed. Different MR contrast agents and MRI techniques for ocular drug-delivery research are compared. Ocular drug-delivery studies using MRI are reviewed.

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Overview of recent advancements in the iontophoretic drug delivery to various tissues and organs

Helmy

2021

Journal of Drug Delivery Science and Technology

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Transtympanic iontophoresis of gadopentetate dimeglumine: preliminary results

Abstract: Transtympanic iontophoresis could be an effective method for the passage of pharmaceutical agents into the middle and inner ear for the treatment of middle and inner ear diseases.

Cited by 4 publications

References 16 publications

Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear

Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear

MRI in ocular drug delivery

Overview of recent advancements in the iontophoretic drug delivery to various tissues and organs

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