Introduction: Bladder stone is more common in developing countries and it is one of the rare diseases affecting children. In recent years, there is an increasing tendency in urologists to have minimal invasive approaches. The aim of this study was to compare the results of surgical bladder stone management in our single tertiary center. Methods: From 159 children younger than 18 years with vesical stones treated during January 2000 to January 2015 in Shohada-e-Tajrish hospital, Tehran, Iran, 146 subjects entered to the study. According to type of intervention, patients stratified to three groups. First group included 80 patients that open cystolithotomy (OCL) was done for them, second group was 39 patients who underwent percutaneous cystolithotomy (PCCL) and third group was 27 patients who treated by transurethral cystolithotripsy with holmium-YAG laser (TULL). Demographic data, hospital stay, operation time, and post operation complications were recorded and comparison were drawn between the three groups. Results: Mean age was 8.3 ± 5.1 years (8.6 ± 5.1, 6 ± 4.2 years for boys and girls, respectively). Mean stone size (MSS) was 2.76 ± 1.07 cm and no significant differences were found between the three groups but it was larger in OCL group. Mean operative time (MOT) was 29.15 ± 7.12 minutes in separate; MOT in TULL was significantly higher than PCCL and OCL respectively (36.3 ± 5.97, 30.54 ± 5.27 and 26.06 ± 6.32 minutes/P = 0.000). Mean hospital stay (MHS) in OCL group was 3.55 ± 1 days that was higher than PCCL and TULL groups significantly (P = 0.000). Conclusion: Based on our study, holmium:YAG lithotripsy has a high success rate, and is a minimally invasive management, therefore it is a safe method for children bladder calculi treatment if proper equipment was available and done by expert hands.