Transurethral microwave thermotherapy of the prostate – Evaluation with MRI and analysis of parameters relevant to outcome

Veselý, Štěpán; Müller, Markus; Knutson, Tomas; Peeker, Ralph; Hellström, Mikael; Dahlstrand, Christer

doi:10.1080/00365590701547076

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…The treatment catheter used in ProstaLund Feedback Treatment (PLFT, CoreTherm) contains a temperature sensor inserted into the prostate (intraprostatic sensor (IP sensor)) and is used to calculate cell kill [1], which is dependent on tissue temperature and treatment time [1][2][3][4]. The calculated cell kill corresponds to tissue destruction seen on transrectal ultrasound, magnetic resonance imaging and histopathology [5][6][7]. Intraprostatic blood flow can increase considerably as a response to heat [2,8] and thereby act as a coolant by lowering the temperature within the prostate [2,3].…”

Section: Introductionmentioning

confidence: 99%

Prostate volume and age are predictors of energy delivery using the CoreTherm Concept in patients with LUTS/BPO: a study on thermal dose

Stenmark

Brudin

Kjölhede

et al. 2020

Scandinavian Journal of Urology

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Objective: The primary aim of this study was to evaluate the scientific evidence supporting the use of thermal dose as a secondary (or an alternative) endpoint when using the CoreTherm Concept. Material and methods: Baseline and treatment data from 283 consecutive treatments were evaluated. All patients had lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). After evaluation, benign prostatic enlargement (BPE) with benign prostatic obstruction (BPO) was evident. As treatment, the CoreTherm Concept was used in all patients with LUTS/BPO. Data parameters were retrospectively extracted and included patient age, prostate volume, energy delivery, treatment time and calculated cell kill. In addition, assessment of temperature curves and calculated intraprostatic blood flow was made to define an optimal treatment. In total, 199 treatments assessed as optimal were included in the study. Results: There was a significant correlation between pretreatment prostate volume and energy delivery (p < .001). Age also influenced energy consumption significantly (p ¼ .01). Conclusion:The solid correlation between pretreatment prostate volume and age versus total energy deposition implies the recommendation that a pretreatment calculation of an appropriate energy deposition should be used in all treatments as an alternative treatment endpoint.

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Section: Introductionmentioning

confidence: 99%

Prostate volume and age are predictors of energy delivery using the CoreTherm Concept in patients with LUTS/BPO: a study on thermal dose

Stenmark

Brudin

Kjölhede

et al. 2020

Scandinavian Journal of Urology

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“…Many researchers have reported the effectiveness of hyperthermia using various materials and methods of heating, such as inductive heating using electromagnetic materials,6, 7 dielectric heating including radiofrequency ablation (RFA),8–10 and microwave coagulation therapy (MCT) 11, 12. However, conventional thermotherapy has been reported to have a few problems.…”

mentioning

confidence: 99%

“…4,5 Many researchers have reported the effectiveness of hyperthermia using various materials and methods of heating, such as inductive heating using electromagnetic materials, 6,7 dielectric heating including radiofrequency ablation (RFA), [8][9][10] and microwave coagulation therapy (MCT). 11,12 However, conventional thermotherapy has been reported to have a few problems. For example, it has been reported that a temperature above 42.5 C caused tumor cell death in vitro, 13 but, for mammalian cells, a temperature above 43 C resulted in irreversible damage to both malignant cells and surrounding normal intact cells 14 and tissues.…”

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confidence: 99%

Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer

Yoshida

Watanabe

Sato³

et al. 2009

Intl Journal of Cancer

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Hyperthermia is a minimally invasive approach to cancer treatment, but it is difficult to heat only the tumor without damaging surrounding tissue. To solve this problem, we studied the effectiveness of chemohyperthermia with docetaxel-embedded magnetoliposomes (DMLs) and an applied alternating current (AC) magnetic field. Human MKN45 gastric cancer cells were implanted in the hind limb of Balb-c/nu/nu mice. Various concentrations of docetaxel-embedded DMLs were injected into the tumors and exposed to an AC magnetic field (n 5 6, each). For comparison with hyperthermia alone, magnetite-loaded liposome (ML)-injected tumors were exposed to an AC magnetic field. Furthermore, the results of DML without AC treatment and docetaxel diluted into PBS with AC treatment were also compared (n 5 10, each). Tumor surface temperature was maintained between 42 and 43°C. Tumor volume was reduced in the DML group with a docetaxel concentration > 56.8 lg/ml, while a docetaxel concentration > 568.5 lg/ml was required for tumor reduction without hyperthermia. Statistically significant differences in tumor volume and survival rate were observed between the DML group exposed to the magnetic field and the other groups. The tumor disappeared in 3 mice in the DML group exposed to the magnetic field; 2 mice survived over 6 months after treatment, whereas all mice of the other groups died by 15 weeks. Histologically, hyperthermia with DML damaged tumor cells and DML diffused homogeneously. To the best of our knowledge, this is the first report to show that hyperthermia using chemotherapeutic agent-embedded magnetoliposomes has an anticancer effect.

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Microwave Therapy

Gravas¹

2012

Smith's Textbook of Endourology

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Transurethral microwave thermotherapy of the prostate – Evaluation with MRI and analysis of parameters relevant to outcome

Cited by 4 publications

References 20 publications

Prostate volume and age are predictors of energy delivery using the CoreTherm Concept in patients with LUTS/BPO: a study on thermal dose

Prostate volume and age are predictors of energy delivery using the CoreTherm Concept in patients with LUTS/BPO: a study on thermal dose

Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer

Microwave Therapy

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