Transvaginal Sonographic Study of Follicular Dynamics in Spontaneous and Clomiphene Citrate Cycles

Debnath, Jyotindu; Satija, Lovleen; Rastogi, V; Dhagat, Peeyush; Sharma, RK; Singh, Hariqbal; Mohan, Rakesh; Khanna, Sudhansoo

doi:10.1016/s0377-1237(17)30161-2

Cited by 3 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies show that about 30-40% of cases of female infertility are caused by ovulation disorders which are in line with our study [ 18 , 19 ]. TVS is a rapid, simple, and noninvasive way of directly observing ovarian follicle development that has no negative impact on the oocyte or reproductive system.…”

Section: Discussionsupporting

confidence: 92%

“…Ovarian hyperstimulation syndrome was detected sonographically in 1.84% of cycles. All these findings are consistent with the findings of our study wherein the leading mean follicular diameter was significantly higher (22-24 mm) in stimulated cycles in contrast to spontaneous cycles (16-21 mm), the follicular growth rate was 2.1 mm/day and 2.2 mm/day, 44% had multi follicular development in the induced cycle and rate of OHSS was 4%, in spontaneous and induced cycles, respectively [18]. These results are in line with those of our study, which showed that the leading mean follicular diameter was considerably larger (22-24 mm) in stimulated cycles than in spontaneous cycles (16-21 mm).…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Study of Folliculometry After Spontaneous and Clomiphene Citrate-Induced Ovulation in Infertile Women

Singh,

Prakash

2023

Cureus

View full text Add to dashboard Cite

Background Ovulatory disruption is the primary reversible cause of infertility, which affects 12-24% of couples. The FDA's first-line recommendation for ovulation induction in such cases is clomiphene citrate. Serial ultrasonography can be used to evaluate follicular development. Methodology The current study is a two-year prospective cohort study conducted at a tertiary care centre. One hundred patients with either primary or secondary infertility and no pelvic pathology were involved in the study and split into two groups: Group I included ovulatory women whose infertility was caused by a factor other than ovulatory disorder, and Group II comprised anovulatory women. Folliculometry was performed using transvaginal sonography; Group I had a spontaneous cycle, whereas Group II received clomiphene citrate (CC) to induce ovulation. The ovulation rate, pregnancy rate, multiple pregnancy rate, and rate of ovarian hyperstimulation (OHSS) were all studied. Results Seventy-two percent of the patients had primary infertility, and most appeared after 3-6 years of infertility. 62% of the patients were between the ages of 21 and 30 years. 50% of cases had ovulatory dysfunction, and polycystic ovarian disease (PCOD) was the most frequent cause of anovulation (24%). The leading follicular diameter was substantially bigger (22-26 mm) in the CC-triggered cycle compared to the spontaneous cycle (16-21 mm). In both spontaneous and induced cycles, the endometrial thickness displayed a linear development pattern during the pre-ovulatory phase and plateaued during the luteal phase. With CC, there was a 68% ovulation rate, a 32% pregnancy rate, a 12.5% multiple pregnancy rate, and a 2% incidence of OHSS. Conclusion Clomiphene citrate increases the rate of ovulation and pregnancy in females having ovulatory disorders.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Study of Folliculometry After Spontaneous and Clomiphene Citrate-Induced Ovulation in Infertile Women

Singh,

Prakash

2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Transvaginal imaging utilizes a higher frequency imaging achieving better resolution of the ovaries. [9][10][11]…”

Section: Methodsmentioning

confidence: 99%

Observational study of changes in dominant ovarian follicle with and without administration of clomiphene citrate in primary infertility cases among eastern Indian women

et al. 2023

View full text Add to dashboard Cite

Background: Changing environment and social factors with advancement of science bestowed the human population with both curse and boon. Increasing number of primary infertility is one of the many challenges which is encountered among 3.59% of Indian women population in reproductive age group. Use of clomiphene citrate (CC) is one of the commonly practiced way to find out a ray of hope. Aims and Objectives: The aim of the study was to measure the changes of morphometric parameters of dominant ovarian follicles and their numbers and compare the same before and after administration of CC was the aim of the present study. Materials and Methods: This interventional and cohort study performed on 50 women coming to the infertility clinic at Institute of Post Graduate Medical Education and Research, Kolkata, with primary infertility of reproductive age group. Informed consent was taken from all. Transvaginal ultrasonography was utilized to measure the parameters related with dominant follicles. Comparison among them with respect to number, size, and time to rupture both before and after ovulation induction with CC was made. Results: Statistically significant increase in number and average size of dominant follicle is seen from 1.08 to 2 and 12.26 to 15.31 mm following CC in the third cycle. In polycystic ovarian disease, cases also ovulation has increased significantly. Conclusion: Transvaginal ultrasonography proves to be regarded as a gold standard procedure to measure and monitor the ovarian follicle status. Undoubtedly CC can be regarded as an easy and dependable solution toward treatment of primary infertility.

show abstract

Role of Transvaginal Sonography in the Diagnosis of Female Infertility: A Comprehensive Review

Thaker,

Dhande,

Parihar

2023

Cureus

View full text Add to dashboard Cite

Female infertility, a complex and emotionally challenging condition, impacts millions of women worldwide. Timely and accurate diagnosis is crucial for tailoring effective solutions to overcome fertility challenges. Transvaginal sonography, a real-time and non-invasive imaging modality, is pivotal in this diagnostic process. This review focuses on the structural abnormalities of the female reproductive system related to female infertility, particularly highlighting the capabilities of transvaginal sonography in assessing ovulatory disorders, structural anomalies, endometrial conditions, ovarian reserve, and other contributing factors. It is important to note that while transvaginal sonography excels in detecting structural abnormalities, it may not effectively identify lifestyle and hormonal changes. This limitation underscores the necessity for a comprehensive diagnostic approach that includes additional modalities to address the multifaceted nature of female infertility. Despite acknowledging the inherent limitations and operator dependence of transvaginal sonography, we emphasize its significance in guiding clinicians toward wellinformed decisions and personalized treatment plans. Looking forward, we anticipate the continual evolution of sonographic technology, offering enhanced diagnostic capabilities. The commitment to improving fertility outcomes for individuals and couples navigating the intricate path toward parenthood remains paramount. In conclusion, a holistic diagnostic approach incorporating various modalities is essential for a thorough understanding and effective management of female infertility.

show abstract

Transvaginal Sonographic Study of Follicular Dynamics in Spontaneous and Clomiphene Citrate Cycles

Cited by 3 publications

References 13 publications

Study of Folliculometry After Spontaneous and Clomiphene Citrate-Induced Ovulation in Infertile Women

Study of Folliculometry After Spontaneous and Clomiphene Citrate-Induced Ovulation in Infertile Women

Observational study of changes in dominant ovarian follicle with and without administration of clomiphene citrate in primary infertility cases among eastern Indian women

Role of Transvaginal Sonography in the Diagnosis of Female Infertility: A Comprehensive Review

Contact Info

Product

Resources

About