Transvaginal ultrasound, endometrial cytology sampled by Gynoscann and histology obtained by Uterine Explora Curette compared to the histology of the uterine specimen: A prospective study in pre‐ and postmenopausal women undergoing elective hysterectomy

Kufahl, Jan; Pedersen, Ivan; Eriksen, Poul Sindberg; Helkjær, Poul Erik; Larsen, Lise Grupe; Jensen, Karen Linnert; Nully, Pia de; Philipsen, T; Wåhlin, Anne

doi:10.3109/00016349709024349

Cited by 31 publications

(34 citation statements)

References 23 publications

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“…The curettage procedure's falsenegative rate is reportedly 2-6% for diagnosis of endometrial cancer and hyperplasia [12,13]. Similar rates have been reported for the less invasive methods [9,12]. Sampling error has been proposed as the main reason for these study results.…”

Section: Discussionsupporting

confidence: 65%

“…Many studies have investigated the effi cacy of transvaginal ultrasonography or endometrial cytology alone as a screening tool for endometrial cancer, but few have investigated combined use of transvaginal ultrasonography and endometrial sampling [8,9] . The present study was conducted to determine whether measuring endometrial thickness by means of transvaginal ultrasonography and obtaining endometrial cytology is a useful diagnostic schema for endometrial cancer and hyperplasia.…”

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confidence: 99%

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Transvaginal Ultrasonography and Endometrial Cytology as a Diagnostic Schema for Endometrial Cancer

Minagawa¹,

Sato²,

Itô³

et al. 2005

Gynecol Obstet Invest

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Objective: To determine whether the combined use of transvaginal ultrasonography and endometrial cytology is an effective diagnostic schema for endometrial cancer and hyperplasia of the uterus. Methods: Five hundred fifty-two women were enrolled in this study. For all subjects, endometrial thickness was evaluated by transvaginal ultrasonography. Endometrial cytology was carried out according to the following criteria: all women with atypical uterine bleeding, for asymptomatic postmenopausal women with endometrial thickness ≧5 mm, and for asymptomatic premenopausal women with endometrial thickness ≧20 mm. When the cytological findings were abnormal, we performed a hysteroscopy-guided biopsy within 2 weeks. Women who received transvaginal ultrasonography alone, or those who showed negative cytology, underwent repeated gynecological examination and transvaginal ultrasonography 3, 6, and 12 months after the first examination. Results: Endometrial cytology was done on 129 women (23.4% of all subjects), of whom 14 were diagnosed as ‘positive’ cytology, 20 as ‘suspicious positive’, and 95 as ‘negative’. A total of 34 women with ‘positive’ or ‘suspicious positive’ cytological result underwent hysteroscopy-guided endometrial biopsy. The histological diagnosis of the endometrium included 13 endometrial cancers, 9 endometrial hyperplasias (one atypical hyperplasia and 3 hyperplastic polyps), and 10 normal endometria. As a diagnostic schema for endometrial cancer, this combined method resulted in 100% sensitivity, 99.1% specificity, 92.9% positive predictive value, and 100% negative predictive value. For endometrial hyperplasia, the method resulted in 100% sensitivity, 89.6% specificity, 40.0% positive predictive value, and 100% negative predictive value. Conclusion: A combination of transvaginal ultrasonography and endometrial cytology may be an effective diagnostic schema for endometrial cancer and hyperplasia.

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Section: Discussionsupporting

confidence: 65%

mentioning

confidence: 99%

Transvaginal Ultrasonography and Endometrial Cytology as a Diagnostic Schema for Endometrial Cancer

Minagawa¹,

Sato²,

Itô³

et al. 2005

Gynecol Obstet Invest

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“…These studies all support the Pipelle as an adequate and equal, if not preferable, sampling device, particularly regarding decreased patient-reported pain. [3][4][5][6][7][8][9][10][11][12] Little data exist comparing a relatively new device, the Explora curette (Milex) 7,13,14 with the Pipelle. 7 The Explora is slightly more rigid than the Pipelle and has a sharp, Randall-type cutting edge on one side of its distal end; it is 19.7-cm-long, with an outer diameter of 3.0 mm, and suction is created by pulling back on a locking syringe.…”

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confidence: 99%

Pain Experienced Using Two Different Methods of Endometrial Biopsy

Leclair

Zia

Doom

et al. 2011

Obstetrics &Amp; Gynecology

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“…Under optimal circumstances the gynecologist will remove a tissue sample from the uterine lining under hysteroscopic control [44-47]. If hysteroscopic control is neglected, the false negative rates for dilatation and curettage (D&C) will range between two and six percent, thereby emphasizing the limitations of D&C alone [45,48-50].…”

Section: Early Detectionmentioning

confidence: 99%

Cancer of the endometrium: current aspects of diagnostics and treatment

et al. 2004

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In spite of the overall good prognosis during the early stages of the disease, the survival is poor in advanced stages or recurrences. Diagnostic measures are very well able to detect asymptomatic recurrences. These only seem justified if patients' chances are likely to improve, otherwise such measures increases costs as well as decrease the patients' quality of life. To date neither current nor improved concepts of endocrine treatment or chemotherapy have been able to substantially increase patients' chances of survival. Therefore, newer concepts into the use of antibodies e.g. trastuzumab in HER2-overexpressing tumors and the newer endocrine compounds will need to be investigated. Furthermore, it would seem highly desirable if future studies were to identify valid criteria for an individualized management, thereby maximizing the benefits and minimizing the risks.

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Transvaginal ultrasound, endometrial cytology sampled by Gynoscann and histology obtained by Uterine Explora Curette compared to the histology of the uterine specimen: A prospective study in pre‐ and postmenopausal women undergoing elective hysterectomy

Abstract: Transvaginal ultrasound is a reliable method in excluding endometrial pathology. The Uterine Explora Curette was superior to Gynoscann in diagnosing neoplasia of the endometrium. It was found to have the same diagnostic accuracy as conventional dilatation and curettage.

Cited by 31 publications

References 23 publications

Transvaginal Ultrasonography and Endometrial Cytology as a Diagnostic Schema for Endometrial Cancer

Transvaginal Ultrasonography and Endometrial Cytology as a Diagnostic Schema for Endometrial Cancer

Pain Experienced Using Two Different Methods of Endometrial Biopsy

Cancer of the endometrium: current aspects of diagnostics and treatment

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