Even if the extent of fatigue damage in fibre-reinforced plastics is limited, it can already affect the elastic properties. Therefore, the damage initiation and propagation in composite structures is monitored very carefully. Beside the use of nondestructive testing methods (ultrasonic inspection, optical fibre sensing), the follow-up of the degradation of engineering properties such as the stiffness is a common approach. In this paper, it is proved that the Poisson's ratio can be used as a sensitive indicator of fatigue damage in fibre-reinforced plastics. Static tests, quasi-static cyclic tests and fatigue tests were performed on [0°/90°] 2s glass/epoxy laminates, and longitudinal and transverse strain were measured continuously. The evolution of the Poisson's ratio ν xy versus time and longitudinal strain ε xx is studied. As the transverse strain measurement is crucial to monitor the degradation of the Poisson's ratio, three techniques were applied to measure the transverse strain (strain gauges, mechanical extensometer and external optical fibre sensor). Finally, the technique has been applied to a totally different material: a carbon fabric thermoplastic composite. The results show a very similar degradation of the Poisson's ratio, although no stiffness degradation can be observed during fatigue loading of this material. It is concluded that the degradation of the Poisson's ratio can be a valuable indicator of fatigue damage, in combination with the stiffness degradation.