Bipolar disorder is a chronic mental illness characterized by alternating episodes of mania and depression, which significantly affect the quality of life of patients and their surroundings. According to the World Health Organization, bipolar disorder ranks sixth among diseases with the highest global morbidity, highlighting its relevance as a public health issue. The objective of this study was to interpret nursing interventions in patients with bipolar disorder through a bibliographic review based on PRISMA 2020 criteria, providing a comprehensive analysis of their impact and effectiveness. A systematic search was conducted in databases such as PubMed, Scopus, Scielo, Redalyc, Lilacs, Dialnet, and Google Scholar, using specific descriptors and Boolean operators. Twenty articles published between 2018 and 2023 in English, Spanish, and Portuguese were selected, meeting the predefined inclusion criteria. The results identified key nursing interventions, including behavioral management, environmental management to prevent violence, promotion of self-care and autonomy, active listening, regulation of habits and lifestyles, assertive pharmacological approaches, and psychoeducation for patients and families. These interventions are characterized by their individualized, comprehensive, and holistic approach, addressing biological, psychological, social, cultural, and spiritual aspects. In conclusion, nursing care for patients with bipolar disorder is a critical element in improving their quality of life, contributing to treatment adherence and the prevention of complications