Trastornos del control de los impulsos y punding en la enfermedad de Parkinson: la necesidad de una entrevista estructurada

Ávila, Asunción; Cardona, Xavier; Bello, J.; Maho, P.; Sastre, F. Fullana; Martı́n-Baranera, Montserrat

doi:10.1016/j.nrl.2010.09.007

Cited by 14 publications

(18 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While premature choices and jumping to conclusions are found in about 20% of the general population [21], our results suggest that subtle underlying impulsivity, only detectable by metric tasks may be even more common in the early stages of PD. Computerized tasks may be more valid than using self-filled questionnaires as people may either lack insight into their impulsivity or deliberately deny such impulsive tendencies [22]. …”

Section: Discussionmentioning

confidence: 99%

Jumping to conclusions in untreated patients with Parkinson's disease

et al. 2016

View full text Add to dashboard Cite

Background Jumping to conclusions due to impulsivity has been shown to be a sensitive marker for dopamine dysregulation and addictive behaviour patterns in treated patients with Parkinson's disease (PD). It is unknown whether drug naïve PD patients, who have never received dopaminergic therapy also have deficits in information sampling. Methods Twenty five de novo PD patients and twenty matched healthy controls were recruited and tested on the beads task, which is a validated information sampling task to assess reflection impulsivity and a temporal discounting questionnaire. Results Patients gathered significantly less information and made more irrational choices than matched controls. There was, however, no group difference on the temporal discounting questionnaire. Conclusions Poor information sampling and irrational decision making may be an inherent component of the neuropsychological deficit in Parkinson's disease. These findings suggest that underlying impulsivity detected by a metric task is common in de novo PD.

show abstract

Section: Discussionmentioning

confidence: 99%

Jumping to conclusions in untreated patients with Parkinson's disease

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The present study used rigorous direct interviews conducted by neurological specialists and found that the prevalence was 5.4% in patients with PD, which is consistent with the figures reported by previous studies. [ 3 , 7 , 24 , 25 ] In terms of the predisposing factors for the development of punding, high daily LED, young age of onset, being male, frequent rescue doses, long PD duration, presence of dyskinesia, and disease severity have been suggested as risk factors. Similarly, our data indicated that long duration of PD and PD medication, high total daily LED, and presence of dyskinesia and ICD were significant risk factors for developing punding behavior.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Neuropsychological Profile and Cortical Thinning in Parkinson’s Disease with Punding

et al. 2015

View full text Add to dashboard Cite

BackgroundPunding, one of dopamine replacement treatment related complications, refers to aimless and stereotyped behaviors. To identify possible neural correlates of punding behavior in patients with Parkinson’s disease (PD), we investigated the patterns of cognitive profiles and cortical thinning.MethodsOf the 186 subjects with PD screened during the study period, we prospectively enrolled 10 PD patients with punding and 43 without punding on the basis of a structured interview. We performed comprehensive neuropsychological tests and voxel-based and regions-of-interest (ROIs)-based cortical thickness analysis between PD patients with and without punding.ResultsThe prevalence of punding in patients with PD was 5.4%. Punding behaviors were closely related to previous occupations or hobbies and showed a temporal relationship to changes of levodopa-equivalent dose (LED). Significant predisposing factors were a long duration of PD and intake of medications of PD, high total daily LED, dyskinesia, and impulse control disorder. Punding severity was correlated with LED (p = 0.029). The neurocognitive assessment revealed that PD patients with punding showed more severe cognitive deficits in the color Stroop task than did those without punding (p = 0.022). Voxel-based analysis showed that PD-punders had significant cortical thinning in the dorsolateral prefrontal area relative to controls. Additionally, ROI-based analysis revealed that cortical thinning in PD-punders relative to PD-nonpunders was localized in the prefrontal cortices, extending into orbitofrontal area.ConclusionsWe demonstrated that PD patients with punding performed poorly on cognitive tasks in frontal executive functions and showed severe cortical thinning in the dorsolateral prefrontal and orbitofrontal areas. These findings suggest that prefrontal modulation may be an essential component in the development of punding behavior in patients with PD.

show abstract

“…It is likely that a large proportion of PD-related ICBs are undiagnosed in routine clinical settings where the symptoms are not specifically looked for. Patients and their families often do not spontaneously disclose ICBs (Avila, Cardona et al 2011), probably for a number of reasons including embarrassment and lack of insight. Furthermore, patients and their families may think that these behaviours are unrelated to PD and therefore irrelevant to their treating physicians.…”

Section: Phenomenology and Epidemiology Of Icbsmentioning

confidence: 99%

Impulsive and Compulsive Behaviors in Parkinson's Disease

Averbeck

Djamshidian

2014

Annu. Rev. Clin. Psychol.

View full text Add to dashboard Cite

Impulsive compulsive behaviours (ICBs) in Parkinson’s disease (PD) are a common and devastating side effect of dopamine replacement therapy. In this review we describe the phenomenology, prevalence and risk factors of these patients. Results of behavioural studies assessing the neuropsychological profile emphasize that the ICBs, which are behavioural addictions, are not hedonically motivated. Rather, other factors such as the inability to cope with uncertainty may be triggering ICBs. New insights from functional imaging studies, strengthening the incentive salience hypothesis are discussed and therapeutic guidelines for the management of ICBs in PD are given.

show abstract

Trastornos del control de los impulsos y punding en la enfermedad de Parkinson: la necesidad de una entrevista estructurada

Abstract: Patients with PD do not spontaneously admit the presence of ICD or punding and these behaviours appear to be under-recognised in clinical practice. A screening questionnaire is needed to ensure their detection.

Cited by 14 publications

References 19 publications

Jumping to conclusions in untreated patients with Parkinson's disease

Jumping to conclusions in untreated patients with Parkinson's disease

Patterns of Neuropsychological Profile and Cortical Thinning in Parkinson’s Disease with Punding

Impulsive and Compulsive Behaviors in Parkinson's Disease

Contact Info

Product

Resources

About