Trastornos relacionados con el gluten y enfermedades desmielinizantes

Hernández-Lahoz, Carlos; Rodrigo, Luís

doi:10.1016/j.medcli.2012.07.009

Cited by 5 publications

(3 citation statements)

References 59 publications

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“…Only in a small number of sporadic cases, the combination CD and neuromyelitis optica was found [157, 158]. GFD is recommended for both disorders, although the long-term neurological response with the diet is not clear [155, 159]. …”

Section: Autoimmune Disorders In Celiac Diseasementioning

confidence: 99%

Celiac Disease and Autoimmune-Associated Conditions

Lauret

Rodrigo

2013

BioMed Research International

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Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. This is primarily explained by the fact that CD belongs to the group of autoimmune diseases. The only one with a known etiology is related to a permanent intolerance to gluten. Remarkable breakthroughs have been achieved in the last decades, due to a greater interest in the diagnosis of atypical and asymptomatic patients, which are more frequent in adults. The known presence of several associated diseases provides guidance in the search of oligosymptomatic cases as well as studies performed in relatives of patients with CD. The causes for the onset and manifestation of associated diseases are diverse; some share a similar genetic base, like type 1 diabetes mellitus (T1D); others share pathogenic mechanisms, and yet, others are of unknown nature. General practitioners and other specialists must remember that CD may debut with extraintestinal manifestations, and associated illnesses may appear both at the time of diagnosis and throughout the evolution of the disease. The implementation of a gluten-free diet (GFD) improves the overall clinical course and influences the evolution of the associated diseases. In some cases, such as iron deficiency anemia, the GFD contributes to its disappearance. In other disorders, like T1D, this allows a better control of the disease. In several other complications and/or associated diseases, an adequate adherence to a GFD may slow down their evolution, especially if implemented during an early stage.

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Section: Autoimmune Disorders In Celiac Diseasementioning

confidence: 99%

Celiac Disease and Autoimmune-Associated Conditions

Lauret

Rodrigo

2013

BioMed Research International

Self Cite

151

111

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“…Studies have shown an increased prevalence of celiac disease and gluten sensitivity in persons with MS and improvement in neurologic symptoms following adoption of a gluten-free diet. 26 – 29 There is long-standing evidence that cow’s milk consumption has a role in the development of MS, whereas lectins (found in grains and legumes) have an apparently similar contributing mechanism. 30 – 33 In contrast, polyphenols (found in fruits, vegetables, herbs, nuts, tea, red wine, algae, coffee, chocolate, olives, and olive oil), carotenoids (from fruits, vegetables, olives, algae, and seafood), polyunsaturated fatty acids (from nuts, seeds, olive oil, seaweed, and fish), vitamin D (found in mushrooms, fish, and liver), and elements such as selenium (found in nuts, fish, and seafood) and zinc (found in nuts and seeds) have the potential to downregulate the expression of inflammatory molecules, interfere with cell signaling, and counteract oxidative stress processes associated with MS. 20 , 21 , 34 , 35 The essential minerals, vitamins B (found in yeast, liver, and vegetables), E (found in nuts, oils, vegetables, and fruits), and K (found in vegetables and liver), as well as the antioxidant and energetic cofactors ALA (found in organ meat, vegetables, and yeast) and ubiquinone (coenzyme Q10; found in meat, fish, vegetables, and olive oil) are involved in mitochondrial metabolism and may provide clinical benefit.…”

Section: Introductionmentioning

confidence: 99%

Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study

Irish¹,

Erickson²,

Wahls³

et al. 2017

DNND

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Background/objectiveA Paleolithic diet may improve fatigue and quality of life in progressive multiple sclerosis (MS) patients, but past research has evaluated the effects of this dietary intervention in combination with other treatments such as exercise. Thus, the purpose of this pilot study was to evaluate a modified Paleolithic dietary intervention (MPDI) in the treatment of fatigue and other symptoms in relapsing-remitting MS (RRMS).MethodsWe measured the effects of a MPDI in 17 individuals with RRMS. Of 34 subjects randomly assigned to control (maintain usual diet) and intervention (MPDI) groups, nine subjects (one man) completed the control group and eight subjects (one man) completed the MPDI.ResultsSignificant improvements were seen in Fatigue Severity Scale score and also in Multiple Sclerosis Quality of Life-54 and time to complete (dominant hand) 9-Hole Peg Test from baseline in MPDI subjects compared to controls. Increased vitamin K serum levels were also observed in MPDI subjects postprotocol compared to controls.ConclusionA Paleolithic diet may be useful in the treatment and management of MS, by reducing perceived fatigue, increasing mental and physical quality of life, increasing exercise capacity, and improving hand and leg function. By increasing vitamin K serum levels, the MPDI may also reduce inflammation.

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“…Among them, wheat allergy measured by immunoglobulin E (IgE), which is characterized by anaphylaxis after consumption of foods derived from this cereal and non-celiac gluten intolerance, which is not measured by IgE or antibodies [23][24][25]. The latter, has a prevalence ten times greater than celiac disease and is considered as an emerging disease from the last decades.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Paper based analytical device modified with nanoporous material for the fluorescent sensing of gliadin content in different food samples

Marín-Barroso

Moreira

Messina

et al. 2018

Microchemical Journal

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A novel fluorescent paper based immunosensor for the quantification of gliadin content in different food samples was constructed. The device consists of a paper platform modified with amino functionalized mesoporous material. The nanoporous structure and the aminofunctionality increased the anti-gliadin antibodies immobilization capacity of the sensing surface, conferring high sensitivity to the system. The detection limit reached by the described system allowed us to address the control of gluten free foods, which is extremely important to maintain the food safe consumption by patients with celiac disease, wheat allergy measured by immunoglobulin E, non-celiac gluten intolerance and Dermatitis herpetiformis or Duhring disease. The gliadin determination was performed by applying a noncompetitive immunoassay format, where gliadin present in food samples was recognized by anti-gliadin antibodies immobilized on the mesoporous material and quantified by the addition of anti-gliadin antibody labelled with peroxidase, its substrate: hydrogen peroxide and a mediator: 10-acetyl-3,7-dihydrofenoxacin. This mediator by the action of the enzyme generates resorufin, which was excited by a light emitting diode at 550 nm and emitted a signal at 580nm. The calibration curve obtained for gliadin exhibited a linear range between 0-160 µg Kg-1 and a method detection limit of 0.025 mg Kg-1. The obtained values for relative recovery varied between 98.65% and 102.33% for samples enriched with gliadin. Also, the results suggested that the developed fluorescent paper based immunosensor showed good reproducibility and stability, indicating its applicability for high-sensitive gluten free food control analysis.

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Trastornos relacionados con el gluten y enfermedades desmielinizantes

Cited by 5 publications

References 59 publications

Celiac Disease and Autoimmune-Associated Conditions

Celiac Disease and Autoimmune-Associated Conditions

Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study

Paper based analytical device modified with nanoporous material for the fluorescent sensing of gliadin content in different food samples

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