Trastuzumab conjugated PEG – Fe₃O₄@Au nanoparticle as an MRI biocompatible nano-contrast agent

Preparation of MnO2@poly-(DMAEMA-co-IA)-conjugated methotrexate nano-complex for MRI and radiotherapy of breast cancer application

“…As shown in Fig. 6b, the percentage of erythrocytes lysis activity of drug-carrying nanoparticles in the investigated concentration range (1.95-2000 µg/mL) was appropriate and less than 5% (standard acceptance limit) indicated the suitable blood compatibility of the prepared nanoparticles [11].…”

“…Gd 3+ -based -CAs have short circulation times and their usage is limited due to free Gd 3+ ions that might be dissociated from chelates, which is responsible for nephrogenic systemic brosis (NSF) in patients [10]. T 1 -weighted CAs are generally preferred because of intrinsic dark signals and the so-called 'blooming artifacts' of T 2 CAs like Fe 3 O 4 -based NPs, but the bright signals of T 1 agents can be easily distinguished from other pathogenic or biological circumstances [11].…”

Safe magnetic resonance imaging on biocompatible nanoformulations

“…43 Their high stability in the biological environment and resistance to uptake by RES make them potentially useful in vivo MRI contrast agent. Subsequently, several PEG-based contrast agents such as Mn 3 O 4 @PEG-Cy7.5 NPs, 44 Gd@Cy5.5@SiO 2 -PEG-Ab NPs, 45 Gd-PEG-PPy NPs, 46 Gd 2 O 3 -PEG- l -Cys-NPs, 47 USPIO-PEG-sLe x NPs, 48 trastuzumab conjugated PEG–Fe 3 O 4 @Au NPs, 49 PEG(5)-BP-USPIOs, 50 and PEG-Arg@IONPs 51 were found to have good scientific outcomes, with good contrast abilities and biocompatibilities. Dextran, a biocompatible polysaccharide consisting of α-1,6 linked d -glucose is widely functionalized on MNP surfaces for stem cell labelling in vitro and in vivo.…”

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

“…Similarly, Gd­(III)-labeled DNA–Au NP conjugates have been fabricated as multifunctional nanoprobes for cancer diagnostics (optical and MRI probes); they exhibited high relaxivity (∼4.5-fold enhancement) relative to the molecular gadolinium­(III) dithiolane complexes . Additionally, Fe 3 O 4 @Au NPs were coated with PEG and conjugated with trastuzumab to acquire NCAs (∼30 nm) with high stability, biocompatibility, and relaxivity as well as no noticeable cytotoxicity ( in vitro ) for targeted MRI of tumors …”

“…76 Additionally, Fe 3 O 4 @Au NPs were coated with PEG and conjugated with trastuzumab to acquire NCAs (∼30 nm) with high stability, biocompatibility, and relaxivity as well as no noticeable cytotoxicity (in vitro) for targeted MRI of tumors. 77 2.1.3. Fe-Based Nanomaterials.…”