Trastuzumab: Designer Drug or Fashionable Fad?

Freebairn, A; Illidge, Tim

doi:10.1053/clon.2001.9306

Clinical Oncology

2001

DOI: 10.1053/clon.2001.9306

|View full text |Cite

Trastuzumab: Designer Drug or Fashionable Fad?

A Freebairn

Tim Illidge

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2003

Publication Types

Select...

Other1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Future Strategies in Immunotherapy

Lake

Dionne

2003

Burger's Medicinal Chemistry and Drug Discovery

View full text Add to dashboard Cite

The following chapter discusses cutting edge, current, and future immunotherapeutic strategies. The first section reviews basic molecular and cellular components of the immune system. The second section emphasizes FDA‐approved humanized and chimeric antibodies for the treatment of cancer and rheumatoid arthritis including herceptin, rituxan, mylotarg, campath, remicade, and Enbrel, because these types of genetically engineered molecules represent the future of molecular medicine treatments. The function and significance of antibody targets are defined where possible. A brief description of clinical trial results and adverse drug reactions is provided for each humanized or chimeric antibody. Formulations of each antibody are also discussed where appropriate. Next, cutting edge strategies using dendritic cells pulsed with tumor associated peptides, tumor cell lysates, apoptotic tumor cells, tumor RNA, and tumor‐derived exosomes are also addressed. Transduction of DC with adenovirus and pox virus vectors is discussed along with ongoing clinical trials and exciting pre‐clinical developments of promising strategies. The chapter concludes with a summary of what must occur in the immunotherapy field for success in the near future.

show abstract

Future Strategies in Immunotherapy

Lake

Dionne

2003

Burger's Medicinal Chemistry and Drug Discovery

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Trastuzumab: Designer Drug or Fashionable Fad?

Cited by 1 publication

References 31 publications

Future Strategies in Immunotherapy

Future Strategies in Immunotherapy

Contact Info

Product

Resources

About