Trasylol in acute pancreatitis

Trapnell, J E; Talbot, C. H.; Capper, W. M.

doi:10.1007/bf02241945

Cited by 48 publications

(28 citation statements)

References 8 publications

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“…Next, all authors read the selected 24 articles, reaching a consensus to exclude seven more articles [27,38-40,45,48,50] including two in which a protease inhibitor was administered to both intervention and control groups [30,45], two that were published as comments [38,50], one in which glucagon was given to the control group [39], one published as an editorial (n = 1) [40], and one reporting an ERCP study [48]. In the end, a total of 17 articles [27-29,31-37,41-44,46,47,49] were selected for analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The present meta-analysis of the retrieved competent studies included 15 RCTs from the handsearch [27,28,31-37,41-43,46,47,49], one [29] from a previous meta-analysis [51], and one [44] from guidelines [52], with the total sample size of 1,697 patients. Of the 15 articles manually searched, 10 [33,34,37,41-44,46,47,49] were used in our previous meta-analysis [10].…”

Section: Resultsmentioning

confidence: 99%

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Treatment of acute pancreatitis with protease inhibitors administered through intravenous infusion: an updated systematic review and meta-analysis

et al. 2014

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BackgroundThe intravenous use of protease inhibitors in patients with acute pancreatitis is still controversial. The purpose of this study was to evaluate the effectiveness of protease inhibitors intravenously administered to prevent pancreatitis-associated complications.MethodsWe updated our previous meta-analysis with articles of randomized controlled trials published from January 1965 to March 2013 on the effectiveness of protease inhibitors for acute pancreatitis. A systematic search of PubMed, EMBASE, the Cochrane Library, and Japana Centra Revuo Medicina was conducted. In addition, Internet-based registries (ClinicalTrials.gov, controlled-trials.com, UMIN, JMACCT, and JAPIC) were used to search for on-going clinical trials. Furthermore, references of review articles and previously published meta-analyses were handsearched. The main outcome of interest was the overall mortality rate from acute pancreatitis.ResultsSeventeen trials were selected for analysis. Overall, protease inhibitors did not achieve a significant risk reduction in mortality (pooled risk difference [RD], -0.02; 95% Confidence Interval [CI], -0.05 to 0.01; number needed to treat [NNT], 74.8) with low heterogeneity. A subgroup analysis in moderate to severe pancreatitis (defined by control mortality rate [CMR] >0.10) did not show a significant effect of protease inhibitors to prevent death (pooled RD, -0.03; 95% CI, -0.07 to 0.01; NNT, 1603.9) with low heterogeneity. An additional subgroup analysis of two trials with CMR >0.20 (i.e., low quality) revealed a significant risk reduction.ConclusionThe present meta-analysis re-confirmed that there is no solid evidence that supports the intravenous use of protease inhibitors to prevent death due to acute pancreatitis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Treatment of acute pancreatitis with protease inhibitors administered through intravenous infusion: an updated systematic review and meta-analysis

et al. 2014

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“…At risk groups, particularly patients with leukaemia, have real mixed infections8 9 and their prognosis is extremely poor. Addicts are another such group, as are newly-born premature infants.…”

Section: Mixed Endocarditis In Addictsmentioning

confidence: 99%

Editorial: Trasylol for pancreatitis.

1974

BMJ

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“…Some have demonstrated benefit [25], whereas most have not [2,26,27]. In general, aprotinin has been administered i.v.…”

Section: Introductionmentioning

confidence: 99%

The effect of peritoneal lavage and aprotinin in the treatment of severe acute pancreatitis

et al. 1983

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Fifty-five patients with severe acute pancreatitis were treated with peritoneal lavage at the Dept. of Surgery at Malmö General Hospital. In a randomized study 26 of the 55 patients received in addition 500,000 KIU aprotinin in the lavage fluid every 2 h. There were no significant differences between the aprotinin- and non-aprotinin-treated groups as to mortality and clinical results. The initial concentration of alpha 1-antitrypsin in plasma was mainly within normal range with increasing values during the treatment. No differences were seen between the two groups. The initial mean level of alpha 2-macroglobulin in plasma was slightly decreased, but 17 patients showed values below normal range. The alpha 2-macroglobulin level during the lavage showed a similar course in the two groups. alpha 1-Antitrypsin and alpha 2-macroglobulin in the lavage fluids showed signs of complexation but in plasma these inhibitors did not show any signs of complexation. On admission to the hospital the mean levels of C3 and kininogen in the plasma were slightly below normal. During the lavage treatment no differences were seen between the two groups. Degradation products of C3 and kininogen were seen in both serum and peritoneal fluids. The electrophoretic patterns of C3 and kininogen normalized in serum as well as in lavage fluids during the lavage treatment without any significant differences in the two groups. High levels of immunoreactive trypsin, pancreatic elastase, PSTI, and leukocyte elastase in serum were seen equally in both groups of patients.

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Trasylol in acute pancreatitis

Cited by 48 publications

References 8 publications

Treatment of acute pancreatitis with protease inhibitors administered through intravenous infusion: an updated systematic review and meta-analysis

Treatment of acute pancreatitis with protease inhibitors administered through intravenous infusion: an updated systematic review and meta-analysis

Editorial: Trasylol for pancreatitis.

The effect of peritoneal lavage and aprotinin in the treatment of severe acute pancreatitis

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