Tratamento do papiloma vírus humano na infância com creme de imiquimode a 5%

Brandt, Hebert Roberto Clivati; Fernandes, Juliana Dumêt; Patriota, Régia Celli Ribeiro; Criado, Paulo Ricardo; Belda, Walter

doi:10.1590/s0365-05962010000400020

Cited by 13 publications

(7 citation statements)

References 15 publications

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“…[ 119 ] Topical sensitizers like SADBE and DPC have been tried on the face and neck and imiquimod on external genital warts in children, both being painless and extremely convenient. [ 120 121 ] Intralesional vaccines and skin test antigens are the most popular kids on the block currently, and are being tried in different sites and patient populations, including children. [ 60 74 ] However, the attendant pain is less likely to find favor with children, unless their topical use (for example, topical BCG) is proven to have consistent documented success in large controlled trials.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulators in warts: Unexplored or ineffective?

2015

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Cutaneous warts are known to be recurrent and often resistant to therapy. Resistant warts may reflect a localized or systemic cell mediated immune (CMI) deficiency to HPV. Many modalities of treatment are in use; most of the provider-administered therapies are destructive and cause scarring, such as cryotherapy, chemical cauterisation, curettage, electrodessication and laser removal. Most patient-applied agents like podophyllotoxin have the risk of application-site reactions and recurrence. Thus immunotherapy is a promising modality which could lead to resolution of warts without any physical changes or scarring and in addition would augment the host response against the causative agent, thereby leading to complete resolution and decreased recurrences. Immunomodulators can be administered systemically, intralesionally or intradermally, and topically. A few agents have been tried and studied extensively such as cimetidine and interferons; others are new on the horizon, such as Echinacea, green tea catechins and quadrivalent HPV vaccine, and their efficacy is yet to be completely established. Though some like levamisole have shown no efficacy as monotherapy and are now used only in combination, other more recent agents require large and long term randomized placebo-controlled trials to clearly establish their efficacy or lack of it. In this review, we focus on the immunomodulators that have been used for the treatment of warts and the studies that have been conducted on them.

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Section: Introductionmentioning

confidence: 99%

Immunomodulators in warts: Unexplored or ineffective?

2015

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“…Os achados da atual revisão corroboram a literatura no que diz respeito ao tratamento do condiloma acuminado no geral, uma vez que 13 foram os trabalhos que utilizaram o Imiqui-mode como alternativa terapêutica 6,[11][12][13][14][15][16][17][18][19][20][21][22] . Contudo, o FDA, Food and Drug Administration, fornece a informação de que são desconhecidas tanto a segurança quanto a eficácia do creme em crianças com menos de 12 anos para o tratamento de verrugas genitais e perianais, não sendo, portanto, oficialmente recomendado para este público 42 .…”

Section: Discussionunclassified

“…Treze trabalhos utilizaram dessa estratégia terapêutica, sendo 12 em monoterapia. A resposta ao tratamento se deu de forma satisfatória na maioria dos pacientes, havendo poucos relatos de efeitos adversos, aos quais em sua maioria apresentaram-se brandos 6,[11][12][13][14][15][16][17][18][19][20][21][22] .…”

Section: Imiquimodeunclassified

Abordagens terapêuticas do Condiloma Acuminado em crianças e adolescentes

Drumond

Castelo

Esperança

et al. 2022

Medicina (Ribeirão Preto)

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Objetivos: A infecção pelo papiloma vírus humano dos tipos 6 e 11 pode evoluir para Condiloma Acuminado. Sua transmissão é principalmente via sexual, de forma que a presença dessas verrugas em crianças deve ser considerada sinal de alarme para investigação de abuso. Eventualmente, contudo, ocorre por autoinoculação ou fômites. O tratamento é desafiador, dado que apesar do extenso arsenal, a recorrência se faz comum. A presente revisão sistemática advém a comparar taxas de sucesso das estratégias terapêuticas, objetivando fornecer substrato para escolha acertada no tratamento da doença em crianças e adolescentes. Métodos: Foi realizada Revisão sistemática baseada no guideline Preferred Report Items for Systematic Reviews and Meta-Analyses (PRISMA), registrada na Plataforma PROSPERO sob identificação CRD42021262090. Resultados: 211 estudos foram encontrados nas databases consultadas, de forma que 30 atenderam as propostas de critérios estabelecidos na pesquisa sistematizada. Esses passaram extração de dados para síntese qualitativa, demonstrando eficácia de métodos não-invasivos a invasivos. Conclusões: Mediante bons resultados em resolução da doença e reduzidos efeitos adversos, a terapia mais popular entre os autores foi o Imiquimode. A pesquisa chamou atenção à necessidade de estudos mais robustos e metodologias mais complexas a cerca das abordagens terapêuticas do Condiloma Acuminado em crianças e adolescentes.

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“…Often these procedures are painful, can result in scarring and require the use of anesthesia. Besides, recurrence of warts may frequently occur [27]. They also count as cryotherapy the use of gels and sprays that carry camphor or menthol in their composition, causing a cooling where they are applied.…”

Section: Human Papillomavirus Conceptsmentioning

confidence: 99%

Pruning Fuzzy Neural Network Applied to the Construction of Expert Systems to Aid in the Diagnosis of the Treatment of Cryotherapy and Immunotherapy

Guimarães

Souza

Araújo

et al. 2019

BDCC

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Human papillomavirus (HPV) infection is related to frequent cases of cervical cancer and genital condyloma in humans. Up to now, numerous methods have come into existence for the prevention and treatment of this disease. In this context, this paper aims to help predict the susceptibility of the patient to forms treatment using both cryotherapy and immunotherapy. These studies facilitate the choice of medications, which can be painful and embarrassing for patients who have warts on intimate parts. However, the use of intelligent models generates efficient results but does not allow a better interpretation of the results. To solve the problem, we present the method of a fuzzy neural network (FNN). A hybrid model capable of solving complex problems and extracting knowledge from the database will pruned through F-score techniques to perform pattern classification in the treatment of warts, and to produce a specialist system based on if/then rules, according to the experience obtained from the database collected through medical research. Finally, binary pattern-classification tests realized in the FNN and compared with other models commonly used for classification tasks capture results of greater accuracy than the current state of the art for this type of problem (84.32% for immunotherapy, and 88.64% for cryotherapy), and extract fuzzy rules from the problem database. It was found that the hybrid approach based on neural networks and fuzzy systems can be an excellent tool to aid the prediction of cryotherapy and immunotherapy treatments.

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Tratamento do papiloma vírus humano na infância com creme de imiquimode a 5%

Cited by 13 publications

References 15 publications

Immunomodulators in warts: Unexplored or ineffective?

Immunomodulators in warts: Unexplored or ineffective?

Abordagens terapêuticas do Condiloma Acuminado em crianças e adolescentes

Pruning Fuzzy Neural Network Applied to the Construction of Expert Systems to Aid in the Diagnosis of the Treatment of Cryotherapy and Immunotherapy

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