Tratamiento actual y nuevas terapias contra la infección crónica por el virus de la Hepatitis B

Echeverri, Simón Gallo; Caraballo, César; Marín, Mateo Orozco; Muñoz, Octavio

doi:10.22516/25007440.138

Rev. Colomb. Gastroenterol.

2017

DOI: 10.22516/25007440.138

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Tratamiento actual y nuevas terapias contra la infección crónica por el virus de la Hepatitis B

Simón Gallo Echeverri

César Caraballo

Mateo Orozco Marín

et al.

Abstract: La infección crónica por el virus de la hepatitis B es un grave problema de salud pública a nivel mundial. Sus consecuencias llegan a ser mortales y el tratamiento actual no ofrece curación sino control de la enfermedad. Las principales limitantes para una cura son la dificultad para destruir el ADNccc del virus en el núcleo celular y la presencia de material genético viral integrado en el ADN de la célula hospedera. No obstante, hay múltiples frentes de investigación enfocados en encontrar una cura definitiva… Show more

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Present and future management of viral hepatitis

Grande¹,

Leiva²,

Ortega³

et al. 2021

WJG

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Viral hepatitis can result in important morbidity and mortality, with its impact on health conditioned by the specific type of hepatitis, the geographical region of presentation and the development and access to new drugs, among other factors. Most acute presentation forms are self-limiting and may even go unnoticed, with just a small percentage of cases leading to acute liver failure that may necessitate transplantation or even cause the death of the patient. However, when they become chronic, as in the case of hepatitis B virus and C virus, unless they are diagnosed and treated adequately they may have severe consequences, like cirrhosis or hepatocarcinoma. Understanding of the mechanisms of transmission, the pathogenesis, the presence of vaccinations and the development over recent years of new highly-efficient, potent drugs have meant that we are now faced with a new scenario in the management of viral hepatitis, particularly hepatitis B virus and hepatitis C virus. The spectacular advances in hepatitis C virus treatment have led the World Health Organization to propose the objective of its eradication by 2030. The key aspect to achieving this goal is to ensure that these treatments reach all the more vulnerable population groups, in whom the different types of viral hepatitis have a high prevalence and constitute a niche that may perpetuate infection and hinder its eradication. Accordingly, micro-elimination programs assume special relevance at the present time.

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Present and future management of viral hepatitis

Grande¹,

Leiva²,

Ortega³

et al. 2021

WJG

View full text Add to dashboard Cite

show abstract

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Tratamiento actual y nuevas terapias contra la infección crónica por el virus de la Hepatitis B

Cited by 1 publication

References 56 publications

Present and future management of viral hepatitis

Present and future management of viral hepatitis

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