Tratamiento con esteroides sistémicos en agudización grave de enfermedad pulmonar obstructiva crónica: empleo de pautas cortas en práctica clínica habitual y relación con la estancia hospitalaria

Marcos, Pedro J.; Nieto-Codesido, Irene; Domínguez-Pazos, Santiago de Jorge; Huerta, Arturo; Márquez, Eduardo; Maiso, Alejandro; Verdeal, Rodrigo; Otero-González, Isabel; Blanco-Aparicio, Marina; Montero-Martínez, Carmen

doi:10.1016/j.arbres.2017.03.012

Cited by 10 publications

(3 citation statements)

References 22 publications

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“…We aimed to assess the use of corticosteroids in COPD exacerbation in a tertiary medical centre. Although GOLD guidelines state a clear recommendation of 5-7 days of treatment (1), the duration is still not well established in clinical practice, and differences regarding corticosteroid administration have been observed in previous studies (7,8), as well as in our study.…”

Section: Discussioncontrasting

confidence: 53%

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Short-Term Versus Long-Term Systemic Corticosteroid Use in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients

Alshehri

Alalawi

Makeen

et al. 2021

MJMS

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Background: The administration of systemic corticosteroids in chronic obstructive pulmonary disease (COPD) exacerbation is the first line of management. The duration of this administration, however, is not well established in clinical practice. The objective of this study is to compare the clinical outcomes between short-term and long-term corticosteroid use in the acute exacerbation of COPD patients. Methods: A single-centre, retrospective cohort study was conducted. From 2014 to 2018, all patients over 40 years old with COPD who were admitted to the hospital with a case of COPD exacerbation and received systemic corticosteroids at presentation were included. The subjects were divided into two groups according to the duration of systemic corticosteroid therapy. The primary outcome was hospital re-admission within 180 days. The secondary outcomes were 30 days mortality and length of hospitalisation. The two groups were compared using an independent sample t-test, a Chi-square test, and a Mann-Whitney U test, according to the data type. Results: Eighty patients met the inclusion criteria. A total of 52 (65%) patients completed long-term therapy, while 28 (35%) patients were on short-term treatment. A total of 15 (28.8%) patients reached the primary endpoint in the long-term treatment group versus 19 (67.9%) in the short-term treatment group (P = 0.001). The 30-day mortality was 4 (7.7%) and 0 (0%), respectively, and the median length of hospitalisation was 6.5 and 7.5 days in the long-term group and short-term group, respectively (P = 0.32, P = 0.88). Conclusion: Long-term corticosteroid use in the management of acute COPD exacerbation was significantly associated with fewer 180 days re-admission. The duration of corticosteroid use remains controversial, and further studies are recommended to assess the relationship between patient profile and adherence to therapy post-discharge with re-exacerbation.

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Section: Discussioncontrasting

confidence: 53%

“…On the contrary, short-term treatment significantly limited exposure to glucocorticoids and their adverse effects (6). The duration of systemic corticosteroid use is still not well established in clinical practice, and differences regarding administration were observed (7,8).…”

Section: Introductionmentioning

confidence: 99%

Short-Term Versus Long-Term Systemic Corticosteroid Use in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients

Alshehri

Alalawi

Makeen

et al. 2021

MJMS

View full text Add to dashboard Cite

show abstract

“…It has been described that hospitalizations induces a greater musculoskeletal weakness and worse functional situation 22 related to different factors such as prolonged inactivity during it or systemic steroid treatments that are not uncommon to be used with doses above the recommended. 23 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Clinical COPD Phenotypes in Patients Who Are Candidates for Lung Transplantation, Complications and Post-Transplant Survival

Marcos

González

Ónega

et al. 2021

Open Respiratory Archives

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Adecuación e impacto pronóstico del tratamiento de las exacerbaciones graves de la enfermedad pulmonar obstructiva crónica

Portolés-Callejón

López-Alfaro

Giménez-Miranda

et al. 2020

Revista Clínica Española

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Tratamiento con esteroides sistémicos en agudización grave de enfermedad pulmonar obstructiva crónica: empleo de pautas cortas en práctica clínica habitual y relación con la estancia hospitalaria

Cited by 10 publications

References 22 publications

Short-Term Versus Long-Term Systemic Corticosteroid Use in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients

Short-Term Versus Long-Term Systemic Corticosteroid Use in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients

Prevalence of Clinical COPD Phenotypes in Patients Who Are Candidates for Lung Transplantation, Complications and Post-Transplant Survival

Adecuación e impacto pronóstico del tratamiento de las exacerbaciones graves de la enfermedad pulmonar obstructiva crónica

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