Tratamiento de la insuficiencia limbal grave mediante cirugía combinada de trasplante de limbo y trasplante de membrana amniótica

López-García, José Santiago; Rivas, L; García-Lozano, I

doi:10.4321/s0365-66912005000700005

Cited by 4 publications

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“…The cornea of patients with LSC defficiency present a reduction of citokeratines CK3 and CK12 and an increase of citokeratine CK19 (34). Furthermore, impression citology allows a study of the ocular surface after interventions such as limbus transplant and amniotic membrane transplant (35,36).…”

Section: Alterations Of the Ocular Surface In Aniridia Patientsmentioning

confidence: 99%

“…Homologous lamellar limbokeratoplasty has been performed in patients with bilateral aniridia with quite acceptable results (56). The combination of limbus transplant and AMT increases the benefit of each separately (35,57). In addition to the typical limbus transplant, at present we can supply LSCs grown artificially on amniotic membrane (58)(59)(60).…”

Section: Treatmentmentioning

confidence: 99%

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Manejo terapéutico de la queratopatía asociada a aniridia congénita

López-García

García-Lozano²,

Rivas

et al. 2006

Arch Soc Esp Oftalmol

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The management of ocular surface diseases due to limbal stem cell deficiency in aniridia is complex but has changed in recent years, as an understanding of the limbal stem cells and their microenvironment has modified the therapeutic approach. The use of autologous serum eye drops, amniotic membrane transplantation, limbal transplantation or cultivated limbal cell transplantation have all been reported as a treatment for several ocular surface diseases.

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Section: Alterations Of the Ocular Surface In Aniridia Patientsmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Manejo terapéutico de la queratopatía asociada a aniridia congénita

López-García

García-Lozano²,

Rivas

et al. 2006

Arch Soc Esp Oftalmol

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“…The various techniques include amniotic membrane grafting,[ 38 ] limbal allografting,[ 39 ] keratolimbal allografting,[ 40 ] cultivated limbal epithelial transplantation,[ 41 ] cultivated oral mucosa epithelial transplantation,[ 42 ] and a combination of limbal allograft and amniotic membrane transplantation. [ 43 ] Most techniques result in stabilizing the ocular surface and halting the progression of the AAK to some extent. Keratoplasty when performed after limbal stem cell augmentation may have a better outcome, especially when combined with systemic immunosuppression.…”

Section: Clinical Featuresmentioning

confidence: 99%

Clinical and molecular aspects of congenital aniridia – A review of current concepts

Tibrewal¹,

Ratna²,

Gour³

et al. 2022

Indian Journal of Ophthalmology

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Congenital aniridia is a pan ocular disorder characterized by partial or total loss of iris tissue as the defining feature. Classic aniridia, however, has a spectrum of ocular findings, including foveal hypoplasia, optic nerve hypoplasia, nystagmus, late-onset cataract, glaucoma, and keratopathy. The latter three are reasons for further visual compromise in such patients. This entity is often due to mutations in the PAX6 (Paired box protein Pax-6) gene. Recently, aniridia-like phenotypes have been reported due to non- PAX6 mutations as in PITX2, FOXC1, FOXD3, TRIM44 , and CYP1B1 as well wherein there is an overlap of aniridia, such as iris defects with congenital glaucoma or anterior segment dysgenesis. In this review, we describe the various clinical features of classic aniridia, the comorbidities and their management, the mutation spectrum of the genes involved, genotype-phenotype correlation of PAX6 and non- PAX6 mutations, and the genetic testing plan. The various systemic associations and their implications in screening and genetic testing have been discussed. Finally, the future course of aniridia treatment in the form of drugs (such as ataluren) and targeted gene therapy has been discussed.

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“…Aunque la aplicación más común de la citología de impresión en la práctica clínica oftalmológica es valorar el grado de metaplasia escamosa conjuntival en pacientes con clínica de ojo seco (12), ésta también ha sido utilizada para valorar el grado de recuperación de la superficie corneal en pacientes tratados con trasplante de membrana amniótica o cirugía combinada de ésta con trasplante de limbo (13)(14)(15).…”

Section: Introductionunclassified

Determinación del grado de metaplasia escamosa del epitelio corneal como factor diagnóstico de insuficiencia limbal

López-García

Rivas

García-Lozano³

2006

Arch Soc Esp Oftalmol

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RESUMENObjetivos: Determinar si existe relación entre el grado de metaplasia escamosa de la superficie corneal mediante citología de impresión y la gravedad clínica en pacientes con insuficiencia limbal. Métodos: Hemos estudiado mediante citología de impresión 98 ojos de pacientes con insuficiencia limbal que fueron divididos en cuatro grupos según la gravedad clínica: 14 ojos no presentaban sintomatología alguna, 34 ojos presentaron un grado leve de insuficiencia limbal, 28 ojos un grado moderado y 22 ojos una insuficiencia limbal grave. A todos los pacientes se les realizó una citología corneal en la que se estudió el tamaño celular, tamaño nuclear, alteraciones nucleares y relación núcleo-citoplasma (N:C), así como la presencia de células caliciformes. Resultados: Los pacientes con insuficiencia limbal asintomática presentaron un tamaño celular medio de 477 DE 140 µm 2 , con una relación N:C de 1:5,25 DE 1,5. Los pacientes con insuficiencia limbal leve presentaron un tamaño celular medio de 764 DE 122,6 µm 2 y una relación N:C de 1:8,2 DE 1,4. Nin- ARTÍCULO ORIGINAL ABSTRACTPurpose: To determine the correlation between the squamous metaplasia grade of the corneal surface and the clinical severity of the limbal deficiency in patients with this disorder. Methods: We studied 98 eyes of patients with limbal deficiency by impression cytology. These patients were divided into four groups in relation to their clinical severity: 14 eyes had no symptoms, 34 eyes showed a mild grade of limbal deficiency, 28 eyes had a moderate grade and 22 eyes had severe limbal deficiency. Corneal cytology was performed in each patient. Cellular size, nuclear size, nuclear changes and the nuclear-cytoplasmic (N:C) ratio were defined in corneal epithelial cells, in addition to evaluation for the presence of goblet cells in the corneal epithelium. Results: In patients with limbal deficiency without symptoms, we found that the cellular size was 477 (SD140) µm 2 and the N:C ratio was 1:5.25 (SD1.5). In patients with mild limbal deficiency, the cellular size was 764 (SD122.6) µm 2 and the N:C ratio was 1:8.2 (SD1.4). These patients did not show corneal

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Tratamiento de la insuficiencia limbal grave mediante cirugía combinada de trasplante de limbo y trasplante de membrana amniótica

Abstract: LT + AMT is a very effective procedure for restoring the ocular surface integrity in patients with severe limbal deficiency. This combination improves the outcomes obtained with LT alone.

Cited by 4 publications

References 0 publications

Manejo terapéutico de la queratopatía asociada a aniridia congénita

Manejo terapéutico de la queratopatía asociada a aniridia congénita

Clinical and molecular aspects of congenital aniridia – A review of current concepts

Determinación del grado de metaplasia escamosa del epitelio corneal como factor diagnóstico de insuficiencia limbal

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