Trauma and oral anticoagulants

O’Mara, Karen; Mavichak, V.

doi:10.1016/s0196-0644(83)80419-3

Cited by 7 publications

(6 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, patients under oral anticoagulation may still be at risk for severe bleeding secondary to minor trauma [17][18][19]. These patients should lower the threshold for more complete diagnostic evaluations on their arrival at the emergency department.…”

Section: Discussionmentioning

confidence: 99%

Posttraumatic Acute Cholecystitis Caused by Intra-Gallbladder Hemorrhage in a Patient with Anticoagulant Therapy

Kirshtein

Lantsberg

Duchno

et al. 2002

European Journal of Trauma

View full text Add to dashboard Cite

Background: With aging of the population, the incidence of trauma victims who are on anticoagulant or antiplatelet treatment is increasing. These patients are at risk of serious hemorrhage even after relatively minor trauma. They can also show bleeding in unusual locations with unusual consequences. Case Study: We report a previously undocumented bleeding complication in an anticoagulated patient, namely a delayed presentation of acute cholecystitis, where cystic duct obstruction was due to bleeding into the gallbladder after blunt abdominal trauma.

show abstract

Section: Discussionmentioning

confidence: 99%

Posttraumatic Acute Cholecystitis Caused by Intra-Gallbladder Hemorrhage in a Patient with Anticoagulant Therapy

Kirshtein

Lantsberg

Duchno

et al. 2002

European Journal of Trauma

View full text Add to dashboard Cite

show abstract

“…Although the safe upper limits of anticoagulant activity for traumatized patients who require emergency surgical procedures have not yet been determined, 25 patients with prothrombin times in the therapeutic range will have increased hemorrhage from sites of injury. One study recommended that the anticoagulant activity should be corrected to a level over the therapeutic range before controlled major general surgery.…”

Section: Discussionmentioning

confidence: 99%

Plasma Activated Clotting Time as an Indicator of Dangerous Hypocoagulability in Warfarin-treated Trauma Patients: A Preliminary Study

et al. 1998

View full text Add to dashboard Cite

This study was conducted to determine the possibility of detecting dangerous hypocoagulability in trauma victims given warfarin by measuring plasma activated clotting time (ACT). Sensitivity of the plasma ACT to warfarin was tested using lyophilized plasmas and plasma samples from nontraumatized but anticoagulated patients. Lyophilized plasmas were also used to evaluate the effect of defects in the intrinsic coagulation system on the plasma ACT. The plasma ACT, measured using a 4.4-mM calcium solution, showed satisfactory prolongation when the thrombotest of matched samples was within the therapeutic range for warfarin therapy. Conversely, the plasma ACT was not prolonged when the only abnormality of matched samples was mild to moderate prolongation of the activated partial thromboplastin time (APTT). These findings suggest that the plasma ACT could be a reliable indicator of dangerous hypocoagulability in trauma patients receiving warfarin therapy during the immediate postinjury period.

show abstract

“…Patients in need of urgent surgery who are anticoagulated with warfarin may be treated by the rapid reversal of warfarin with intravenous vitamin K (8) and/or the administration of FFP. Limiting the administration of FFP, or other blood products, is a worthy goal in all patients in order to prevent transfusion-transmitted viral illnesses, allergic reactions and volume overload (13).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, this therapy should be limited to emergent situations and utilized only with a careful understanding of both inherent risk and proven benefit. Pub-lished administration guidelines should be adhered to closely (8).…”

Section: Discussionmentioning

confidence: 99%

“…Because of the slow onset of action of vitamin K administered via the intramuscular route, our practice has been to administer dilute vitamin K via a slow intravenous infusion (at a rate no greater than 1 mg/min) as early as possible following notification of an appropriate donor organ. The use of intravenous vitamin K has been reported and is justified in emergency settings (8)(9)(10).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Intravenous vitamin K₁ prior to orthotopic heart transplantation: effects in vivo and in vitro

Barnette¹,

Wendling²,

Schweiger³

et al. 1997

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

Trauma and oral anticoagulants

Cited by 7 publications

References 54 publications

Posttraumatic Acute Cholecystitis Caused by Intra-Gallbladder Hemorrhage in a Patient with Anticoagulant Therapy

Posttraumatic Acute Cholecystitis Caused by Intra-Gallbladder Hemorrhage in a Patient with Anticoagulant Therapy

Plasma Activated Clotting Time as an Indicator of Dangerous Hypocoagulability in Warfarin-treated Trauma Patients: A Preliminary Study

Intravenous vitamin K₁ prior to orthotopic heart transplantation: effects in vivo and in vitro

Contact Info

Product

Resources

About

Trauma and oral anticoagulants

Cited by 7 publications

References 54 publications

Posttraumatic Acute Cholecystitis Caused by Intra-Gallbladder Hemorrhage in a Patient with Anticoagulant Therapy

Posttraumatic Acute Cholecystitis Caused by Intra-Gallbladder Hemorrhage in a Patient with Anticoagulant Therapy

Plasma Activated Clotting Time as an Indicator of Dangerous Hypocoagulability in Warfarin-treated Trauma Patients: A Preliminary Study

Intravenous vitamin K1 prior to orthotopic heart transplantation: effects in vivo and in vitro

Contact Info

Product

Resources

About

Intravenous vitamin K₁ prior to orthotopic heart transplantation: effects in vivo and in vitro