Trauma and Squamous Skin Cancer

Gardner, A. Ward

doi:10.1016/s0140-6736(59)91831-8

Cited by 22 publications

(4 citation statements)

References 3 publications

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“…''Acute'' Marjolin's ulcers, with a latency of less than 1 year, have also been reported; they constitute about 4.6% of patients with Marjolin's ulcers. These may occur as early as 6 weeks after injury [7,10]. Environmental and genetic factors may play a role in patients with acute burn scar neoplasms, leading to shortened latency periods [7].…”

Section: Introductionmentioning

confidence: 99%

Marjolin’s Ulcers in sub‐Saharan Africa

Nthumba

2010

World j. surg.

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Section: Introductionmentioning

confidence: 99%

Marjolin’s Ulcers in sub‐Saharan Africa

Nthumba

2010

World j. surg.

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“…Trauma has been implicated as the cause of many forms of malignant tumors, but the evidence for a single uncomplicated trauma alone causing cancer is largely circumstantial. Trauma is regarded as a cocarcinogen only, with malignancy developing on rare occasions when some other, unknown, cocarcinogenic agent is also operative (Arons et al, 1965(Arons et al, ,1966Gardner, 1959;Monkman et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

Breast cancer arising in surgical scars

Freund

Biran

Laufer

et al. 1976

Journal of Surgical Oncology

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Twelve women who developed breast cancer at the site of old surgical scars in the breast are presented. Six had had former breast biopsies, 3 drainage of breast abscesses, and 3 developed breast cancer in old thoracotomy scars transversing the breast. The combination of trauma as an oncogen and scar tissue as a functional and immunological locus minoris resistentia seems to play a major role in the development of breast cancer in this group of patients. The associaton of breast cancer, scar, and trauma would not be coincidental. Increased attention drawn to this entity may lead to a rise in the number of cases diagnosed among patients with breast scars after biopsies, abscesses, trauma, or foreign body implantation.

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“…One example of this is the high incidence of squamous cell carcinomas that develop around healing burns (1,2). These observations suggest that it is the healing process associated with the injury that promotes cancer (3)(4)(5)(6). The study in which a single CO2 laser incision promotes cancer development (7) directly supports this hypothesis.…”

mentioning

confidence: 89%

Bombesin antagonist prevents CO2 laser-induced promotion of oral cancer.

Kozacko

Mang

Schally

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

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We previously reported that CO2 laser incisions in carcinogen-initiated fields promoted cancer development and caused release of growth factors. Here we examined the quantitative and additive properties of this tumorpromoting event and examined whether this promotion could be nullified by treatment with a bombesin antagonist, which down-regulates epidermal growth factor receptors. The model used for cancer promotion was the hamster buccal cheek pouch that had been treated with a carcinogen (9,10-dimethyl-1,2-benzanthracene) for 6 weeks, producing premalignant lesions. These (17)(18)(19)(20)(21)(22).The relationship between cancer and growth factors has received much attention over the past several decades (23)(24)(25).

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Trauma and Squamous Skin Cancer

Cited by 22 publications

References 3 publications

Marjolin’s Ulcers in sub‐Saharan Africa

Marjolin’s Ulcers in sub‐Saharan Africa

Breast cancer arising in surgical scars

Bombesin antagonist prevents CO2 laser-induced promotion of oral cancer.

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