Background: Mental ill-health and substance use bear substantial burden and harms on young people, and often arise from co-occurring and compounding risk factors, such as traumatic stress. Trauma-informed prevention of mental ill-health and substance use demonstrates significant promise in reducing this burden. A systematic literature review is required to identify and summarise the effectiveness, feasibility, acceptability, and design principles underpinning existing trauma-informed mental ill-health and/or substance use prevention programs for young people aged 12-24 years.
Methods: MEDLINE, Embase, CINAHL, PsychINFO and Cochrane Library will be searched from 2012 through September 2022 as will Informit, Analysis and Policy Observatory (APO), and Google (Advanced Search) for relevant grey/unpublished literature. Reference lists of included articles will be citation chained. Title and abstracts will be screened and two reviewers will review articles full-text. One reviewer will extract data from eligible articles using a piloted data extraction form, and 20% of data will be verified by a second reviewer. Risk of bias will be assessed using the Cochrane risk-of-bias tool for randomised trials (RoB 2), Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I), and Confidence in the Evidence from Reviews of Qualitative Research (GRADE CERQual) tool, depending on the study type. Characteristics of existing trauma-informed mental ill-health and/or substance use prevention programs for young people will be summarised narratively. Effectiveness, feasibility, and acceptability will be qualitatively described and summarised, with proportions and effect sizes quantitatively synthesised, where possible.
Discussion: Trauma-informed approaches to prevention demonstrate significant promise yet to date no study has systematically summarised and synthesised the available literature. To fill this gap, the present review will systematically identify and summarise the effectiveness, feasibility, acceptability, and design principles underpinning existing trauma-informed mental health and/or substance use prevention programs for young people aged 12-24. This review will inform development, adaptation, evaluation and implementation of future traumainformed mental ill-health and substance use prevention programs for young people. Findings will inform critical efforts to interrupt and prevent already elevated trajectories of mental ill-health, substance use and related harms among those young people exposed to adversity.
Systematic review registration This review protocol has been submitted to PROSPERO (CRD42022353883).