Trauma patients with hypokalemia have an increased risk of morbidity and mortality

Schlögl, Mathias; Käch, Ilja; Beeler, Patrick E.; Pape, Hans‐Christoph; Neuhaus, Valentin

doi:10.1016/j.sipas.2021.100041

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…This indicates that patients admitted to the intensive care unit with abnormal potassium levels have a worse prognosis. 4 Abensur VL et al, reported that serum potassium disturbances are bound to increase mortality in patients with chronic diseases like diabetes mellitus, hypertension, ischemic heart diseases, congestive heart failure, and kidney failure. Both hyper-and hypokalemia are expected to worsen these patients' prognoses.…”

Section: Resultsmentioning

confidence: 99%

“…Up to 50% trauma patients and 2.5% of elderly subjects aged ≥75 years are reported to have hypokalemia. 1,4,5,6 Approximately 80% of patients on diuretics and 0.9% of those receiving antimicrobial agents reported having hypokalemia. Drug disease interactions (DDiIs) and drug-drug interactions (DDIs) are expected to enhance the possibility of hypokalemia.…”

Section: Introductionmentioning

confidence: 99%

“…Drug disease interactions (DDiIs) and drug-drug interactions (DDIs) are expected to enhance the possibility of hypokalemia. 1,4,5 Although a sufficient number of publications are available on hypokalemia worldwide, there are few studies in the Indian population. Rehan HS et al, and Mayee KR et al, published on drug-induced hypokalemia in hospitalised patients, and Kunder SK et al, reported with case series analysis.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of ADRs with Hypokalaemia for Severity, Preventability and Causality in a Tertiary Care Centre in South India

Nanjundappa,

et al. 2023

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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Hypokalemia is one of the most frequently seen electrolyte disturbances in clinical practice. Various drugs are known to induce hypokalemia, such as furosemide, thiazides, dicloxacillin, ampicillin, etc. The objective of this study is to assess hypokalemia adverse drug reactions (ADRs) for severity, preventability, and causality in a tertiary care centre in the southern part of India. It is a retrospective, cross-sectional study. Data collected at DMWIMS Medical College, India, as per the ongoing pharmacovigilance program of India from November 1st, 2016 to October 30th, 2017 (12 month period) was included for analysis in this study. The SADR form published by the Government of India under the PVPI program was used for collecting the data. In-patients who were on at least one medication and experienced hypokalemia ADR with or without other symptoms or signs were included. Both primary suspected drugs and concomitantly prescribed drugs were analyzed. For the assessment of ADRs, modified Hartwig and Siegel assessment scales and plasma K+ level criteria were used for severity, Schumock and Thornton criteria for preventability, the WHO-UMC scale, and Naranjo's algorithm for causality, respectively. Sixty hypokalemia ADRs were considered for analysis. Both genders were equally affected, with a mean age of 64.28 ± 3.02 years. Four groups of drugs were suspected to cause hypokalemia viz., anti-asthmatics (36.67 %), diuretics (31.67 %), antibiotics (18.33 %), and antidiabetics (13.33 Polypharmacy was reported in 43.33% of cases, with 4.40 ± 01.689 drugs prescribed on average. To summarize, hypokalemia is a preventable ADR and minor variations in serum K+ levels can have a negative impact on patients' outcomes and mortality. FDC of Levosalbutamol with Ipratropium Bromide was the most common causative agent suspected of causing hypokalemia. Elderly patients receiving one or more drugs that are known to alter K+ levels, need close monitoring, and correction of hypokalemia should be done to improve prognosis. Further studies are required to understand the mechanisms involved in DDIs and DDiIs to derive preventive strategies.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analysis of ADRs with Hypokalaemia for Severity, Preventability and Causality in a Tertiary Care Centre in South India

Nanjundappa,

et al. 2023

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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“…Conversely, an excessive release of adrenocorticotropic hormone (ACTH) may result in cerebral salt-wasting syndrome (CSWS), causing excessive urinary Na + loss. In addition, patients diagnosed with hypokalemia following TBI present an increased risk of morbidity and mortality resulting from alterations in fluid balance [ 160 , 161 ]. So, it is essential to monitor and correct any electrolyte imbalances to promote adequate neurological protection.…”

Section: Introductionmentioning

confidence: 99%

Cellular and Molecular Pathophysiology of Traumatic Brain Injury: What Have We Learned So Far?

Freire,

Rocha,

Bittencourt

et al. 2023

Biology

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Traumatic brain injury (TBI) is one of the leading causes of long-lasting morbidity and mortality worldwide, being a devastating condition related to the impairment of the nervous system after an external traumatic event resulting in transitory or permanent functional disability, with a significant burden to the healthcare system. Harmful events underlying TBI can be classified into two sequential stages, primary and secondary, which are both associated with breakdown of the tissue homeostasis due to impairment of the blood–brain barrier, osmotic imbalance, inflammatory processes, oxidative stress, excitotoxicity, and apoptotic cell death, ultimately resulting in a loss of tissue functionality. The present study provides an updated review concerning the roles of brain edema, inflammation, excitotoxicity, and oxidative stress on brain changes resulting from a TBI. The proper characterization of the phenomena resulting from TBI can contribute to the improvement of care, rehabilitation and quality of life of the affected people.

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Hyperkalaemia in bleeding trauma patients: A potential marker of disease severity – A retrospective cohort study

Eichinger,

Rief,

Eichlseder

et al. 2024

Heliyon

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Trauma patients with hypokalemia have an increased risk of morbidity and mortality

Cited by 4 publications

References 24 publications

Analysis of ADRs with Hypokalaemia for Severity, Preventability and Causality in a Tertiary Care Centre in South India

Analysis of ADRs with Hypokalaemia for Severity, Preventability and Causality in a Tertiary Care Centre in South India

Cellular and Molecular Pathophysiology of Traumatic Brain Injury: What Have We Learned So Far?

Hyperkalaemia in bleeding trauma patients: A potential marker of disease severity – A retrospective cohort study

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