“…Other sequelae of interpersonal violence exposure that have been linked to chronic pain and opiate use warrant investigation in this SCD population, including posttraumatic stress symptoms of physiological hyperarousal, emotional numbing and dysregulation, chronic avoidance and hypervigilance, dissociation, and stress-related breakdowns in bodily function (Afari et al, 2014; Beckham et al, 1997; Berger, Piralic-Spitzl, & Aigner, 2014; Humphreys, Cooper, & Miaskowski, 2010; Moeller-Bertram, Keltner, & Strigo, 2012; Outcalt et al, 2015; Wuest et al, 2009; Wuest et al, 2008). Variables that have been shown to be associated with the severity of SCD symptoms and SCD-related health care such as SCD-related stigma (Bediako et al, 2016) also should be examined both as contributors to anxiety and depressive symptoms in SCD and as potential mediators of the relationship between violence exposure and chronic pain and opiate use in SCD.…”