Trauma

Eckert, Matthew J.; Martin, Matthew J.

doi:10.1016/j.suc.2017.06.008

Cited by 230 publications

(85 citation statements)

References 65 publications

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“…However, non-traumatic conditions, such as cancer, inflammation, infections, or spinal disc degeneration, could also induce SCI [3]. This deleterious condition leads to a serious effect in subjects affected by this disorder, damaging their mental state, labor ability, and social behavior [4]. The main clinical manifestations of SCI include alterations of somatic sensation, voluntary movement, urinary function, and systolic and diastolic functions.…”

Section: Introductionmentioning

confidence: 99%

Stem Cells Therapy for Spinal Cord Injury: An Overview of Clinical Trials

Silvestro

Bramantı

Trubiani

et al. 2020

IJMS

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Spinal cord injury (SCI) is a traumatic lesion that causes disability with temporary or permanent sensory and/or motor deficits. The pharmacological approach still in use for the treatment of SCI involves the employment of corticosteroid drugs. However, SCI remains a very complex disorder that needs future studies to find effective pharmacological treatments. SCI actives a strong inflammatory response that induces a loss of neurons followed by a cascade of events that lead to further spinal cord damage. Many experimental studies demonstrate the therapeutic effect of stem cells in SCI due to their capacity to differentiate into neuronal cells and by releasing neurotrophic factors. Therefore, they appear to be a valid strategy to use in the field of regenerative medicine. The purpose of this paper is to provide an overview of clinical trials, recorded in clinical trial.gov during 2005–2019, aimed to evaluate the use of stem cell-based therapy in SCI. The results available thus far show the safety and efficacy of stem cell therapy in patients with SCI. However, future trials are needed to investigate the safety and efficacy of stem cell transplantation.

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Section: Introductionmentioning

confidence: 99%

Stem Cells Therapy for Spinal Cord Injury: An Overview of Clinical Trials

Silvestro

Bramantı

Trubiani

et al. 2020

IJMS

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“…Traumatic spinal cord injury (SCI) is usually caused by an external physical impact damage to the spinal cord and contributes to everlasting neurological impairment and dysfunction and burdens individuals, families, and the society with a high economic cost [1]. Even though survive the initial injury, the SCI patients face great risks of medical complications throughout their lives, which is often related to infectious morbidity, leading to significant reductions in life quality and expectancy [2]. Advanced therapies such as decompression, functional stimulation, neurorehabilitation, nerve and tendon transfers, and neural bypass, as well as drug treatments, surgery, and cell transplantation, are currently promising strategies for SCI, but there are no available regenerative treatments to date to cure the disease [3,4].…”

Section: Introductionmentioning

confidence: 99%

Promoting functions of microRNA-29a/199B in neurological recovery in rats with spinal cord injury through inhibition of the RGMA/STAT3 axis

Yang

Sun

2020

J Orthop Surg Res

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Background The prognostic and therapeutic potential of microRNAs (miRNAs) in spinal cord injury (SCI) has aroused increasing concerns. This study aims to research the functions of miR-29a/199B in the neurological function recovery after SCI and the mechanical mechanism. Methods A rat model with SCI was induced with sham-operated ones as control. The locomotor function and coordination of rat hindlimbs were determined by a Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and a ladder-climbing test, respectively. Expression of a neurofilament protein NF-200 and synaptophysin in gray matter of rats was determined to evaluate neuronal recovery in a cellular perspective. Binding relationships between miR-29a/199B with RGMA were predicted and validated using luciferase assays. Altered expression of miR-29a/199B and RGMA was introduced to explore their functions in rat neurological functions. The protein level and phosphorylation of STAT3 in gray matter were measured by western blot analysis. Results miR-29a and miR-199B were poorly expressed, while RGMA was abundantly expressed in gray matter at injury sites. Either miR-29a or miR-199B could bind to RGMA. Overexpression of miR-29a/199B or silencing of RGMA led to an increase in BBB locomotor scores, hindlimb coordination ability, and the expression of NF-200 and synaptophysin in gray matter. Further inhibition in miR-29a/199B blocked the promoting roles of RGMA silencing in neurological recovery. Upregulation of miR-29a/199B or downregulation of RGMA suppressed the phosphorylation of STAT3. Conclusion This study evidenced that miR-29a and miR-199B negatively regulated RGMA to suppress STAT3 phosphorylation, therefore promoting the neurological function recovery in rats following SCI.

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“…Действительно, невозможно исключить травму живота или таза, основываясь на клиническом обследовании в соответствии со стандартами Advanced Trauma Life Support (ATLS) [10]. Травма позвоночника с повреждением или без спинного мозга, в частности шейного отдела, может привести к тяжелым неврологическим повреждениям, и диагностика такой травмы становится источником споров среди врачей с растущим согласием по поводу того, что одной лишь рентгенографии недостаточно для исключения травм, особенно в случаях с сомнительным механизмом травмы [11]. Компьютерная томография (КТ) обладает оптимальными характеристиками для диагностики травм из-за возможности достаточно быстрого обследования при высокой чувствительности и специфичности [12].…”

Section: Introductionunclassified

Full-body CT scan in Polytrauma Diagnosis. Analysis of Ten Years’ Experience

Gareev

Beylerli

Визгалова

2020

Kreativnaâ hirurgiâ i onkologiâ

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Introduction. A computed tomography (CT) scan of the entire body has become a standard practice for the diagnosis of patients with polytrauma in many trauma centres. Purpose: evaluation of diagnostic potential of full-body CT for patients with polytrauma.Materials and methods. In the period from January 2008 to December 2018, all hemodynamically stable patients (scoring 3 and above in the Abbreviated Injury Scale (AIS) and 15 and above in the Injury Severity Score (ISS)) admitted to the Main Republican Head Injury Centre CCH №21 in Ufa with injuries in two or more anatomical areas have undergone CT scanning of head, neck (including cervical spine), chest (including thoracic spine), abdominal cavity/pelvis (including lumbar spine).Results and discussion. In the period from January 2008 to December 2018, 1498 CT examinations were conducted. Out of these examinations, 1368 and 143 cases were polytrauma — (on average 2 cases per week) and monotrauma (10 % of the study group) patients. Only 17 patients failed to complete the examination for polytrauma due to deteriorating status. All of these 17 had been returned to the intensive care unit without delay.Conclusion. In a decade 1368 patients met the established criteria for an immediate CT scan for the diagnosis of polytrauma at a large hospital providing emergency healthcare. A broad range of significant injuries was diagnosed quickly, accurately and safely. These injuries included 31 cervical spine fractures and 56 pneumothoraxes not evidenced by conventional X-ray images.

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Trauma

Cited by 230 publications

References 65 publications

Stem Cells Therapy for Spinal Cord Injury: An Overview of Clinical Trials

Stem Cells Therapy for Spinal Cord Injury: An Overview of Clinical Trials

Promoting functions of microRNA-29a/199B in neurological recovery in rats with spinal cord injury through inhibition of the RGMA/STAT3 axis

Full-body CT scan in Polytrauma Diagnosis. Analysis of Ten Years’ Experience

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