Traumatic Brain Injury and Major Depressive Disorder

Thombs, Brett D.

doi:10.1001/jama.2010.1170

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…The strong negative association between inattention and Conscientiousness fits with this interpretation because prior personality research has demonstrated that Conscientiousness predicts functioning in key areas such as health outcomes and adaptive vs. maladaptive coping (see O'Cleirigh et al, 2007). Thus, low Conscientiousness and inattention may be the manifestation of poor executive functioning in the personalities of adults with ADHD and these difficulties are often the primary target of psychosocial treatment (e.g., Safren et al, 2010; Solanto et al, 2010). …”

Section: Discussionmentioning

confidence: 99%

“…Fifty-nine men and 58 women ( N = 117; age 18 – 65) completed baseline assessment for one of two studies of cognitive-behavioral therapy for adult ADHD at a large New England hospital (Safren et al, 2005; Safren et al, 2010). All participants had a pre-existing ADHD diagnosis from a provider outside of the study and were being treated with medications for ADHD, but continued to meet full criteria for the disorder confirmed by structured clinical interview (Orvaschel, 1985).…”

Section: Methodsmentioning

confidence: 99%

“…All participants had a pre-existing ADHD diagnosis from a provider outside of the study and were being treated with medications for ADHD, but continued to meet full criteria for the disorder confirmed by structured clinical interview (Orvaschel, 1985). Details of clinical assessment procedures are described in Safren et al (2010).…”

Section: Methodsmentioning

confidence: 99%

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Adult Attention Deficit Hyperactivity Disorder Symptoms and Five-Factor Model Traits in a Clinical Sample

Knouse

Traeger

O’Cleirigh

et al. 2013

Journal of Nervous &Amp; Mental Disease

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Relationships among Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms and adult personality traits have not been examined in larger clinically diagnosed samples. We collected multi-source ADHD symptom and self-report NEO Five-Factor Inventory (Costa & McCrae, 1992a) data from 117 adults with ADHD and tested symptom-trait associations using structural equation modeling. The final model fit the data. Inattention was positively associated with Neuroticism and negatively associated with Conscientiousness. Based on ADHD expression in adulthood, hyperactivity and impulsivity were estimated as separate constructs and showed differential relationships to Extraversion and Agreeableness. A significant positive relationship between Hyperactivity and Conscientiousness arose in the context of other pathways. ADHD symptoms are reliably associated with personality traits, suggesting a complex interplay across development that warrants prospective study into adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Adult Attention Deficit Hyperactivity Disorder Symptoms and Five-Factor Model Traits in a Clinical Sample

Knouse

Traeger

O’Cleirigh

et al. 2013

Journal of Nervous &Amp; Mental Disease

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“…Little empirical research guides treatment selection for this comorbidity, although it is beginning to receive greater attention in the literature (Wilens et al, 2008). We hypothesize that depression treatments targeting increases in planned, goal-oriented activities (behavioral activation, Dimidjian et al (2006)) or integration of depression treatment with approaches that help patients develop compensatory skills for EF deficits (e.g., Safren et al, 2010) may be particularly useful for patients with both depression and significant EF impairment or ADHD, but further research is needed.…”

Section: Discussionmentioning

confidence: 99%

Does executive functioning (EF) predict depression in clinic-referred adults?: EF tests vs. rating scales

Knouse

Barkley

Murphy³

2013

Journal of Affective Disorders

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Background Deficits in executive functioning (EF) are implicated in neurobiological and cognitive-processing theories of depression. EF deficits are also associated with Attention-deficit/hyperactivity disorder (ADHD) in adults, who are also at increased risk for depressive disorders. Given debate about the ecological validity of laboratory measures of EF, we investigated the relationship between depression diagnoses and symptoms and EF as measured by both rating scales and tests in a sample of adults referred for evaluation of adult ADHD. Method Data from two groups of adults recruited from an ADHD specialty clinic were analyzed together: Adults diagnosed with ADHD (N=146) and a clinical control group of adults referred for adult ADHD assessment but not diagnosed with the disorder ADHD (N=97). EF was assessed using a rating scale of EF deficits in daily life and a battery of tests tapping various EF constructs. Depression was assessed using current and lifetime SCID diagnoses (major depression, dysthymia) and self-report symptom ratings. Results EF as assessed via rating scale predicted depression across measures even when controlling for current anxiety and impairment. Self-Management to Time and Self-Organization and Problem-Solving showed the most robust relationships. EF tests were weakly and inconsistently related to depression measures. Limitations Prospective studies are needed to rigorously evaluate EF problems as true risk factors for depressive onset. Conclusions EF problems in everyday life were important predictors of depression. Researchers and clinicians should consistently assess for the ADHD-depression comorbidity. Clinicians should consider incorporating strategies to address EF deficits when treating people with depression.

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“…Clinically, emotional dysregulation has been frequently found to occur in mTBI in addition to physical and cognitive symptoms, and it worsens with mental exertion (Silverberg et al, 2020) sadness and fatigue were among the most commonly reported post-concussion emotional symptoms in mTBI patients 3 months post-injury (Levin & Diaz-Arrastia, 2015;Ponsford et al, 2011). The current link observed between the amygdala and hippocampal dysregulation in mTBI may provide evidence of emotional circuit vulnerability that explains why individuals with mTBI are susceptible to developing emotionrelated comorbid psychopathologies (Zheng et al, 2019) including depression (Bombardier et al, 2010;Madsen et al, 2018;Stein et al, 2019;Thombs, 2010) and anxiety disorders, and posttraumatic stress disorder (Betthauser et al, 2018;Santhanam et al, 2019;Stein et al, 2019;Vanderploeg et al, 2009) which are known comorbid conditions highly developed in mTBI (Levin & Diaz-Arrastia, 2015).…”

Section: Amygdala Dysregulation In Mtbi: Potential Cognitive-exerted ...mentioning

confidence: 91%

Memory retrieval brain–behavior disconnection in mild traumatic brain injury: A magnetoencephalography and diffusion tensor imaging study

Hung

Vandewouw

Emami

et al. 2022

Human Brain Mapping

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Mild traumatic brain (mTBI) injury is often associated with long-term cognitive and behavioral complications, including an increased risk of memory impairment. Current research challenges include a lack of cross-modal convergence regarding the underlying neural-behavioral mechanisms of mTBI, which hinders therapeutics and outcome management for this frequently under-treated and vulnerable population. We used multi-modality imaging methods including magnetoencephalography (MEG) and diffusion tensor imaging (DTI) to investigate brain-behavior impairment in mTBI related to working memory. A total of 41 participants were recruited, including 23 patients with a first-time mTBI imaged within 3 months of injury (all male, age = 29.9, SD = 6.9), and 18 control participants (all male, age = 27.3, SD = 5.3). Whole-brain statistics revealed spatially concomitant functional-structural disruptions in brainbehavior interactions in working memory in the mTBI group compared with the control group. These disruptions are located in the hippocampal-prefrontal region and, additionally, in the amygdala (measured by MEG neural activation and DTI measures of fractional anisotropy in relation to working memory performance; p < .05, twoway ANCOVA, nonparametric permutations, corrected). Impaired brain-behavior connections found in the hippocampal-prefrontal and amygdala circuits indicate brain dysregulation of memory, which may leave mTBI patients vulnerable to increased environmental demands exerting memory resources, leading to related cognitive and emotional psychopathologies. The findings yield clinical implications and highlight a need for early rehabilitation after mTBI, including attention-and sensory-based behavioral exercises.

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Traumatic Brain Injury and Major Depressive Disorder

Cited by 4 publications

References 3 publications

Adult Attention Deficit Hyperactivity Disorder Symptoms and Five-Factor Model Traits in a Clinical Sample

Adult Attention Deficit Hyperactivity Disorder Symptoms and Five-Factor Model Traits in a Clinical Sample

Does executive functioning (EF) predict depression in clinic-referred adults?: EF tests vs. rating scales

Memory retrieval brain–behavior disconnection in mild traumatic brain injury: A magnetoencephalography and diffusion tensor imaging study

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