Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets

Padmakumar, Smrithi; Kulkarni, Praveen; Ferris, Craig F.; Bleier, Benjamin S.; Amiji, Mansoor M.

doi:10.1016/j.biopha.2022.112812

Cited by 15 publications

(4 citation statements)

References 184 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Improved functional performance, enhanced antioxidant capacities and neuroprotection of mid-brain neurons in MP treated group lead us to quantitative investigation of DA, the crucial neurotransmitter mediating movement functions [ 52 ]. Previous study revealed rotenone-mediated mitochondrial complex-1 inhibition lead to the formation of free radicals, and impaired DA levels.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson’s disease through anti-oxidant capacities

Anjum,

Raza,

Faheem

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world. Neurodegeneration of the substantia nigra (SN) and diminished release of dopamine are prominent causes of this progressive disease. The current study aims to evaluate the protective potential of ethanolic extract of Mentha piperita (EthMP) against rotenone-mediated PD features, dopaminergic neuronal degeneration, oxidative stress and neuronal survival in a mouse model. Swiss albino male mice were assigned to five groups: control (2.5% DMSO vehicle), PD (rotenone 2.5 mg/kg), EthMP and rotenone (200mg/kg and 2.5mg/kg, respectively), EthMP (200 mg/kg), and Sinemet, reference treatment containing levodopa and carbidopa (20 mg/kg and rotenone 2.5mg/kg). Behavioral tests for motor functional deficit analysis were performed. Anti-oxidant capacity was estimated using standard antioxidant markers. Histopathology of the mid-brain for neurodegeneration estimation was performed. HPLC based dopamine level analysis and modulation of gene expression using quantitative real-time polymerase chain reaction was performed for the selected genes. EthMP administration significantly prevented the rotenone-mediated motor dysfunctions compared to PD group as assessed through open field, beam walk, pole climb down, stepping, tail suspension, and stride length tests. EthMP administration modulated the lipid peroxidation (LPO), reduced glutathione (GSH), and superoxide dismutase (SOD) levels, as well as glutathione-s-transferase (GST) and catalase (CAT) activities in mouse brain. EthMP extract prevented neurodegeneration in the SN of mice and partially maintained dopamine levels. The expression of genes related to dopamine, anti-oxidant potential and synapses were modulated in M. piperita (MP) extract treated mice brains. Current data suggest therapeutic capacities of MP extract and neuroprotective capacities, possibly through antioxidant capacities. Therefore, it may have potential clinical applications for PD management.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson’s disease through anti-oxidant capacities

Anjum,

Raza,

Faheem

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Whether peripheral trauma precipitates parkinsonism or worsens pre-existing parkinsonism has remained controversial since the first description of Parkinson's disease (PD) by James Parkinson [85]. Repeated head trauma and even single traumatic brain injury have been proposed as risk factors for parkinsonism [86][87][88][89], but the data on peripheral trauma triggering parkinsonism is relatively sparse. Earlier reports from our center described well-documented cases of parkinsonism developing a few days or weeks after peripheral trauma [16].…”

Section: Parkinsonismmentioning

confidence: 99%

Peripherally-induced Movement Disorders: An Update

Lenka¹,

Jankovic

2023

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

Background: Peripherally-induced movement disorders (PIMD) should be considered when involuntary or abnormal movements emerge shortly after an injury to a body part. A close topographic and temporal association between peripheral injury and onset of the movement disorders is crucial to diagnosing PIMD. PIMD is under-recognized and often misdiagnosed as functional movement disorder, although both may co-exist. Given the considerable diagnostic, therapeutic, and psychosocial-legal challenges associated with PIMD, it is crucial to update the clinical and scientific information about this important movement disorder.Methods: A comprehensive PubMed search through a broad range of keywords and combinations was performed in February 2023 to identify relevant articles for this narrative review. Results:The spectrum of the phenomenology of PIMD is broad and it encompasses both hyperkinetic and hypokinetic movements. Hemifacial spasm is probably the most common PIMD. Others include dystonia, tremor, parkinsonism, myoclonus, painful leg moving toe syndrome, tics, polyminimyoclonus, and amputation stump dyskinesia. We also highlight conditions such as neuropathic tremor, pseudoathetosis, and MYBPC1associated myogenic tremor as examples of PIMD.Discussion: There is considerable heterogeneity among PIMD in terms of severity and nature of injury, natural course, association with pain, and response to treatment. As some patients may have co-existing functional movement disorder, neurologists should be able to differentiate the two disorders. While the exact pathophysiology remains elusive, aberrant central sensitization after peripheral stimuli and maladaptive plasticity in the sensorimotor cortex, on a background of genetic (two-hit hypothesis) or other predisposition, seem to play a role in the pathogenesis of PIMD.

show abstract

“…Besides presenting with motor symptoms, PD patients also present with dementia, hallucinations, and cognitive decline. There is considerable evidence suggesting that multiple subtypes of TBI accelerates the neuropathology of PD, therefore early signs of PD should be assessed for early intervention [ 77 ]. Behavioral changes are observed early in PD, including motivational decline and slowed thinking [ 78 ].…”

Section: Cognitive and Behavioral Manifestationsmentioning

confidence: 99%

Traumatic Brain Injury and Secondary Neurodegenerative Disease

et al. 2022

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is a devastating event with severe long-term complications. TBI and its sequelae are one of the leading causes of death and disability in those under 50 years old. The full extent of secondary brain injury is still being intensely investigated; however, it is now clear that neurotrauma can incite chronic neurodegenerative processes. Chronic traumatic encephalopathy, Parkinson’s disease, and many other neurodegenerative syndromes have all been associated with a history of traumatic brain injury. The complex nature of these pathologies can make clinical assessment, diagnosis, and treatment challenging. The goal of this review is to provide a concise appraisal of the literature with focus on emerging strategies to improve clinical outcomes. First, we review the pathways involved in the pathogenesis of neurotrauma-related neurodegeneration and discuss the clinical implications of this rapidly evolving field. Next, because clinical evaluation and neuroimaging are essential to the diagnosis and management of neurodegenerative diseases, we analyze the clinical investigations that are transforming these areas of research. Finally, we briefly review some of the preclinical therapies that have shown the most promise in improving outcomes after neurotrauma.

show abstract

Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets

Cited by 15 publications

References 184 publications

Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson’s disease through anti-oxidant capacities

Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson’s disease through anti-oxidant capacities

Peripherally-induced Movement Disorders: An Update

Traumatic Brain Injury and Secondary Neurodegenerative Disease

Contact Info

Product

Resources

About