Traumatic Brain Injury in Children and Adolescents

Guthrie, Elisabeth; Mast, Joelle; Richards, P. G.; McQuaid, Monica; Pavlakis, Steven G.

doi:10.1016/s1056-4993(18)30155-x

Cited by 15 publications

(12 citation statements)

References 88 publications

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“…Following the acute phase of injury, accurate assessment of memory and learning is particularly critical in childhood TBI, given that it is one of the most-often disrupted aspects of cognition in brain injury and is a sensitive predictor of outcome (Anderson, Catroppa, Morse, & Haritou, 1999;Anderson et al, 2000;Guthrie et al, 1999;Woodward & Donders, 1998). Equally important, the adequate evaluation of memory and learning governs the choice of appropriate intervention strategies in the areas of rehabilitation and education.…”

Section: Assessment Of Memory and Learning In Pediatric Tbimentioning

confidence: 99%

“…Traumatic brain injury (TBI) continues to be the leading cause of death (Graham, 2001;Jankowitz & Adelson, 2006) and one of the most frequent causes of disability in children (Arffa, 1998;Bigler, Clark, & Farmer, 1996) with an estimated annual childhood and adolescent incidence between 180 and 300 per 100,000 (Anderson, Catroppa, Rosenfeld, Haritou, & Morse, 2000;Guthrie, Mast, Richards, McQuaid, & Pavlakis, 1999). Although better survival rates have been reported in children compared with adults with TBI, the long-term consequences are typically more devastating due to their age and thus compromised developmental potential (Mazzola & Adelson, 2002).…”

Section: Introduction: Memory Learning and Academic Achievement In mentioning

confidence: 99%

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Memory and Learning in Pediatric Traumatic Brain Injury: A Review and Examination of Moderators of Outcome

Lajiness-O’Neill

Erdődi

Bigler

2010

Applied Neuropsychology

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Section: Assessment Of Memory and Learning In Pediatric Tbimentioning

confidence: 99%

Section: Introduction: Memory Learning and Academic Achievement In mentioning

confidence: 99%

Memory and Learning in Pediatric Traumatic Brain Injury: A Review and Examination of Moderators of Outcome

Lajiness-O’Neill

Erdődi

Bigler

2010

Applied Neuropsychology

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“…Children have a higher survival rates compared to adults with head trauma; but, the long-term sequelae are often more devastating in children depending on the age and developmental period (1). The cognitive dysfunction is a common sequela of head trauma, which is not limited to severe injury but it can be seen in mild and moderate injury (4,17,31,32).…”

Section: Introductionmentioning

confidence: 99%

The combined treatment with progesterone and magnesium sulfate positively affects the traumatic brain injury in immature rats.

Uysal¹,

Baykara²,

Kıray³

et al. 2012

Turkish Neurosurgery

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AIm:It is well known that head trauma results in damage in hippocampal and cortical areas of the brain and impairs cognitive functions. The aim of this study is to explore the neuroprotective effect of combination therapy with magnesium sulphate (MgSO4) and progesterone in the 7-days-old rat pups subjected to contusion injury. mAterIAl and methOds: Progesterone (8 mg/kg) and MgSO4 (150 mg/kg) were injected intraperitoneally immediately after induction of traumatic brain injury. Half of groups were evaluated 24 hours later, the remaining animals 3 weeks after trauma or sham surgery. Anxiety levels were assessed with open field activity and elevated plus maze; learning and memory performance were evaluated with Morris Water maze in postnatal 27 days.results: Combined therapy with progesterone and magnesium sulfate significantly attenuated trauma-induced neuronal death, increased brain VEGF levels and improved spatial memory deficits that appear later in life. Brain VEGF levels were higher in rats that received combined therapy compared to rats that received either medication alone. Moreover, rats that received combined therapy had reduced hipocampus and prefrontal cortex apoptosis in the acute period.COnClusIOn: These results demonstrate that combination of drugs with different mechanisms of action may be preferred in the treatment of head trauma.KeywOrds: Traumatic brain injury, Immature rat, Spatial learning and memory, Apoptosis, VEGF, Magnesium sulfate, Progesterone ÖZ AmAÇ: Kafa travmasının hipokampal ve kortikal hasar ile kognitif fonksiyonlarda bozulmaya neden olduğu bilinmektedir. Bu çalışmanın amacı, magnezyum sülfat (MgSO4) ve progesteronun combine kullanımının kontüzyon hasarı oluşturulan 7 günlük sıçan beynindeki nöroprotektif etkilerini araştırmaktır. yÖntem ve GereÇler: Travmadan hemen sonra 8 mg/kg dozunda progesteron, 150 mg/kg dozunda MgSO4 intraperitoneal tek doz olarak verildi. Deney gruplarının yarısı travmadan 24 saat sonra, kalan yarısı ise 27 günlük olduklarında değerlendirildi. Anksiyete deneyleri açık alan ve yükseltilmiş + labirent test düzenekleri kullanılarak; öğrenme ve bellek performansı ise Morris su tankı aracılığı ile 27 günlükken değerlendirildi.BulGulAr: Kombine tedavinin beyin dokusunda VEGF'yi arttırarak travma ile oluşan nöronal ölümü azalttığı ve ileriki dönemde spasyal bellek bozukluğunu iyileştirdiği görüldü. VEGF seviyesinin kombine tedavide ilaçların tek başına kullanımına göre daha fazla arttığı bulundu. Ayrıca ilaç tedavisinin akut dönemde de VEGF seviyesini arttırarak apoptozis seviyesini azalttığı görüldü. sOnuÇ: Bu sonuçlar, farklı etki mekanizmasına sahip ilaçların kombine kullanımının kafa travması tedavisinde tercih edilebileceğini göstermektedir.

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“…Worldwide, closed head injuries (CHI) in children are a rapidly growing public health issue (Guthrie, Mast, Richards, McQuaid, & Pavlakis, 1999;Jennett, 1996). In the United States, the incidence of CHI is estimated at approximately 250 per 100,000 in youth under age 18 (Guthrie et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Attributions of behavior in the pediatric mild closed head injury (CHI) population

Antshel

Malhotra

Seigers

2007

Psychology, Health & Medicine

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Forty-one children between the ages of 6 and 11 years with a history of a mild closed head injury and 23 age-, gender-, and IQ-matched typically developing control children participated. All of the children in the CHI sample were referred for a magnetic resonance imaging (MRI) scan at 3 months post-injury and children in the CHI sample were further divided into MRI-Negative (n=31) and MRI-Positive (n=10) conditions according to the MRI results. Parents and teachers completed behavioral checklists at three points, including just prior to the MRI and 6 months post-injury. Prior to the MRI (Time 2), in both samples of children with a CHI, parents reported an increase in externalizing symptoms after the CHI. At 6 months post-injury (Time 3: post-MRI), parents of children in the MRI-Positive group did not report any significant changes in their child's externalizing behaviors when compared with pre-MRI, yet parents of children in the MRI-Negative group reported a further increase in externalizing behaviors. Parent attributions also changed as a function of group membership; whereas no changes were noted in the other two groups, parents of children in the MRI-Negative sample ascribed more controllability at Time 3 when compared with Time 2.

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Traumatic Brain Injury in Children and Adolescents

Cited by 15 publications

References 88 publications

Memory and Learning in Pediatric Traumatic Brain Injury: A Review and Examination of Moderators of Outcome

Memory and Learning in Pediatric Traumatic Brain Injury: A Review and Examination of Moderators of Outcome

The combined treatment with progesterone and magnesium sulfate positively affects the traumatic brain injury in immature rats.

Attributions of behavior in the pediatric mild closed head injury (CHI) population

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