Traumatic dental injuries in Serbian children: Epidemiological study

Vuković, Ana; Marković, Dejan; Petrović, Bojan; Apostolovic, Mirjana; Golijanin, Ranko; Kanjevac, Tatjana; Stojković, Branislava; Peric, Tamara; Blagojevic, Duska

doi:10.2298/sarh1312744v

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…4,9,13–16 However, the therapeutic role of VIP in managing UC is still not well established and conflicting findings have been reported. 17,18 The labile peptide VIP undergoes rapid degradation once administered systemically; therefore, delivering the required amounts of the peptide to the target site becomes challenging. 19 In order to be effective in vivo, the free VIP needs to be administered parenterally at higher doses and with increased frequency, which results in severe toxicities such as hypotension and tachycardia.…”

Section: Introductionmentioning

confidence: 99%

“…The anti-inflammatory properties of VIP have been demonstrated in animal models of several immune disorders such as septic shock, multiple sclerosis, rheumatoid arthritis (RA), , and CD. , During severe inflammation in the intestine, levels of VIP and its receptors are known to be down-regulated. , Furthermore, VIP knockout mice show profound abnormalities along the GI tract, indicating the importance of VIP in health and disease of the intestine . VIP has also been studied as a potential candidate for the management of CD in animal models and has shown promising results. ,,− However, the therapeutic role of VIP in managing UC is still not well established and conflicting findings have been reported. , The labile peptide VIP undergoes rapid degradation once administered systemically; therefore, delivering the required amounts of the peptide to the target site becomes challenging . In order to be effective in vivo, the free VIP needs to be administered parenterally at higher doses and with increased frequency, which results in severe toxicities such as hypotension and tachycardia. , Thus, one important reason for variability in the previous studies could be explained by potential variations in the administered VIP reaching the sites of disease.…”

Section: Introductionmentioning

confidence: 99%

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Vasoactive Intestinal Peptide Nanomedicine for the Management of Inflammatory Bowel Disease

Jayawardena¹,

Anbazhagan²,

Guzman³

et al. 2017

Mol. Pharmaceutics

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Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the intestine, with increasing incidence worldwide. At present, the management of IBD is an unmet medical need due to the ineffectiveness of currently available drugs in treating all patients, and there is strong demand for novel therapeutics. In this regard, vasoactive intestinal peptide, a potent anti-inflammatory endogenous hormone, has shown promise in managing multiple immune disorders in animal models. However, when administered in the free form, VIP undergoes rapid degradation in vivo, and with continuous infusion, it causes severe dose limiting side effects. To overcome these barriers, we have developed a superior mode to deliver VIP in its native form, using sterically stabilized micelles (VIP-SSM). Our previous studies demonstrated that, VIP, when administered in SSM, prevented joint damage and inflammation in a mouse model of rheumatoid arthritis at a significantly lower dose than the free peptide, completely abrogating the serious side effect of hypotension associated with VIP. In the current study, we demonstrate the therapeutic benefit of VIP-SSM over free peptide in reversing severe colitis associated with IBD. First, we conducted preliminary studies with dextran sulfate sodium (DSS) induced colitis in mice, to determine the effectiveness of VIP administered on alternate days in reducing disease severity. Thereafter, a single intra peritoneal injection of VIP-SSM or the free peptide was used to determine its therapeutic effect on the reversal of colitis and associated diarrhea. The results demonstrated that when administered on alternate days, both VIP-SSM and VIP were capable of alleviating DSS colitis in mice. However, when administered as a single dose, in a therapeutic setting, VIP-SSM showed superior benefits compared to the free peptide in ameliorating colitis phenotype. Namely, the loss of solid fecal pellets and increased fluid accumulation in colon resulting from DSS insult was abrogated in VIP-SSM treated mice and not with free VIP. Furthermore, reduced protein and mRNA levels of the major chloride bicarbonate exchanger, down regulated in adenoma (DRA), seen with DSS was reversed with VIP-SSM, but not with the free peptide. Similarly, VIP-SSM treatment significantly reduced the elevated mRNA levels of pro-inflammatory cytokines and showed significant histologic recovery when compared to mice treated with free VIP. Therefore, these results demonstrated that as a single dose, the anti-inflammatory and antidiarrheal effects of VIP can be achieved effectively when administered as a nanomedicine. Therefore, we propose VIP-SSM to be developed as a potential therapeutic tool for treating ulcerative colitis, a type of IBD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vasoactive Intestinal Peptide Nanomedicine for the Management of Inflammatory Bowel Disease

Jayawardena¹,

Anbazhagan²,

Guzman³

et al. 2017

Mol. Pharmaceutics

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“…Regarding the place of injury, our results revealed that during office-hours injuries occurred more commonly in school and kindergarten, which was expected. 24 Having in mind that these variables were not independent risk factors for unfavorable outcome, differences in the place of occurrence, mechanism, and cause of injury were marked as insignificant findings, and were not regarded as factors that contributed to poorer outcomes of after-hours TDI.…”

Section: Discussionmentioning

confidence: 99%

After-Hours Versus Office-Hours Dental Injuries in Children

Vuković

Marković

et al. 2015

Clin Pediatr (Phila)

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Prevalence and Causes of Traumatic Dental Injuries to Anterior Teeth Among Primary School Children in Sana'a City, Yemen

et al. 2020

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Objectives: The current study was conducted to reveal the prevalence and causes of traumatic dental injuries to permanent anterior teeth among mixed dentition of schoolchildren in Sana'a City, Yemen. Methods: A cross-sectional study was performed on 1252 schoolchildren aged 7-12 years in three districts of Sana'a city, Yemen. They numbered 700 males and 552 females from 26 randomly selected public and private schools. Clinical examination of permanent anterior teeth was done according to the classification of Ellis modified by Fried. Results: Prevalence of TDI was 10.30%, with a male ratio of 4.8: female 1, (P <0.05). Most of the children suffered only one damage to the tooth and most of them are in the maxillary central incisors. The TDI increased with older age (10-12 years old) (16.5%) with odds ratio 4.8, (p<0.05). Regarding the site of trauma, most injuries happened in males on the street (44.9%) while in females happened at home (31.81%) and falls were the main cause of TDI. In both sexes, the most common type of injury was class I (enamel fracture) followed by class II (enamel and dentine without pulp involvement). Conclusion: In conclusion, the prevalence of TDI in permanent anterior teeth among mixed dentition of school children in Sana’a was high, higher in males than in females, with a peak age of 10 to 12 years, falls was the common cause, and occurred mostly on the street for boys and home for females. Accordingly, educational programs should be developed that focus on ways to prevent dental trauma and the benefits of seeking urgent treatment to maintain avulsed and fractured teeth. Peer Review History: Received 13 May 2020; Revised 15 June; Accepted 1 July, Available online 15 July 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Alfonso Alexander Aguileral Affiliation: University of Veracruz, Mexico E-mail: aalexander_2000@yahoo.com Name: Dr. Mohamed Awad Mousnad Affiliation: Faculty of Pharmacy, International University of Africa (IUA), Khartoum, Sudan E-mail: m_abdalaziz@yahoo.com Name: Dr. Asia Selman Abdullah Affiliation: Al-Razi university, Department of Pharmacy, Yemen E-mail: asia_abdullah65@yahoo.com Comments of reviewer(s): Similar Articles: SERO-PREVALENCE OF HEPATITIS C VIRUS AMONG DENTAL CLINIC WORKERS IN SANA’A CITY- YEMEN AND THE RISK FACTORS CONTRIBUTING FOR ITS INFECTION

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Traumatic dental injuries in Serbian children: Epidemiological study

Abstract: Dental injuries in preschool children most frequently resulted from fall at home. Schoolchildren most frequently injured teeth outdoor during play. Violence and sport injuries were most frequent cause of injury in adolescents.

Cited by 4 publications

References 19 publications

Vasoactive Intestinal Peptide Nanomedicine for the Management of Inflammatory Bowel Disease

Vasoactive Intestinal Peptide Nanomedicine for the Management of Inflammatory Bowel Disease

After-Hours Versus Office-Hours Dental Injuries in Children

Prevalence and Causes of Traumatic Dental Injuries to Anterior Teeth Among Primary School Children in Sana'a City, Yemen

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