Traumatic granuloma of the tongue (human and experimental)

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

“…Nevertheless, attempts to experimentally induce EU revealed conflicting results. Although Bhaskar and Lilly [7] induced the development of EU by repeated injuries, a similar experimental approach by von Domarus et al [31] did not confirm the role of trauma in EU. …”

“…clobetasol, flucinonide, triamcinolone) or mouthwash, intralesional or oral steroids, topical antibiotics, curettage, and cryotherapy. In selected cases, radiotherapy can be applied [6,7,29]. …”

“…As this disorder is of great interest for several medical specialties, such as dermatologists, otolaryngologists and dentists, various daunting terms have been used to characterize this disorder. These include, ulcerated granuloma eosinophilicum diutinum of the tongue [1], a term that has been abandoned, EU [2,3,4,5,6], traumatic granuloma [7,8], eosinophilic granuloma [9,10], traumatic eosinophilic granuloma [11,12], ulcerative eosinophilic granuloma [13,14], traumatic ulcerative granuloma with stromal eosinophilia [15,16], traumatic eosinophilic ulcer [17,18], and a combination of these. Adding to this list, identical clinical features exclusively seen in nursing infants are known as Riga-Fede disease [19].…”

Eosinophilic Ulcer of the Tongue: A case report with immunohistochemical study.

“…The ulcer bed was composed of a dense mixed infiltrate of pale staining histiocytes, lymphocytes and eosinophils (Figs. [2][3][4][5] . These cells infiltrated adjacent skeletal muscle , indicating a variable degree of degeneration and fragmentation (Figs.3-5).…”

Riga-Fede Disease

“…They further suggested that the proliferation of capillaries and myoblasts may be compensatory, and the infiltration of histiocytes and eosinophils is reactive and reparative, all promoting healing of the lesion. 4 The experimental findings reported by Bhaskar and Lilly 5 and by Shteyer et al 6 on traumatized rat tongues strongly implicated trauma as a causative factor for eosinophilic granuloma of the human tongue.…”