Traumatic lateral abdominal wall hematoma treated with <scp>K</scp>ampo medicines

Nakae, Hajime; Okuyama, Manabu; Igarashi, Toshiko

doi:10.1002/tkm2.1022

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…The individual herbal components of JDI have been confirmed to have antioxidant properties [5]. Moreover, we have previously demonstrated the antioxidant activity of JDI and have reported that JDI could be useful for not only contusions and sprains, but also for rib and extremity fractures [6][7][8][9]. In acute inflammation, reactive oxygen species are involved in enhancing vascular permeability resulting in swelling.…”

Section: Discussionmentioning

confidence: 99%

Traumatic asphyxia successfully treated with jidabokuippo

Nakae

Irie

Satoh

et al. 2020

Traditional & Kampo Medicine

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Case: A 29-year-old man presented with traumatic asphyxia associated with symptoms of ecchymosis over the face, conjunctival hyperemia, and a blood-red puffy face. Jidabokuippo (JDI), a traditional Japanese Kampo medicine to alleviate static blood™ 1 was administered. The blood-red puffy face improved dramatically. Outcome: Symptoms improved after treatment with JDI. Conclusion: JDI can be used for the management of ecchymosis and swelling following traumatic asphyxia.

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Section: Discussionmentioning

confidence: 99%

Traumatic asphyxia successfully treated with jidabokuippo

Nakae

Irie

Satoh

et al. 2020

Traditional & Kampo Medicine

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“…We have used JDI for various trauma such as rib fractures, fractures of extremities, abdominal wall hematoma, and traumatic asphyxia ( Nakae et al, 2012 ; Nakae et al, 2015a ; Nakae et al, 2016 ; Kitamura et al, 2022 ; Nakae et al, 2015b ; Nakae et al, 2020 .).…”

Section: Effectiveness Of Jidabokuippomentioning

confidence: 99%

“… a Calculated according to the previous reports ( Sudo and Oribe, 2005 ; Sakurai et al, 2006 ; Takeda, 2010 ; Nakae et al, 2012 ; Nakae et al, 2015a ; Yoshida, 2015 ; Hasegawa et al, 2016 ; Nakae et al, 2016 ; Saito et al, 2019 ; Kitamura et al, 2022 ). …”

Section: Safety Of Jidabokuippomentioning

confidence: 99%

Application of Traditional Japanese Drug Jidabokuippo in a Modern Society

et al. 2022

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Background: Jidabokuippo (JDI) (治打撲一方) has been used in Japan to alleviate contusion-induced swelling and pain since medieval times.Method: This review investigated the effects of JDI on various symptoms in patients with trauma or static blood[TM1]. The PubMed and Igaku Chuo Zasshi databases were searched until 24 December 2021. We summarize the benefits of applying JDI to inflammatory conditions, including bruises.Results: JDI has been used to resolve blood [TM1] stasis, regulate qi in trauma patients, and treat inflammatory swelling and pain caused by rheumatoid arthritis and cellulitis. As the adverse event rate associated with JDI is low (1.3%), JDI is considered a safe drug.Conclusion: JDI can be used to resolve blood[TM1] stasis in trauma patients without adverse events associated with nonsteroidal anti-inflammatory drugs.

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“…The concept of blood stasis also involved hematoma and deep vein thrombosis. In university hospital, KBG was used for treating hematoma in emergency department (60). Kumanomido et al reported that KBG diminished subcutaneous hematoma after surgery in a case report (61).…”

Section: Varicose Vein Hematoma and Deep Vein Thrombosismentioning

confidence: 99%

A Review on the Mechanism and Application of Keishibukuryogan

2021

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The concept of “blood stasis” – called yū xiě in Chinese, Oketsu in Japanese – is one of the unique pathophysiology of traditional medicine that originated in China and inherited in Korea and Japan. This concept is related to the multiple aspects of hemodynamic disorders brought on by quantitative and qualitative changes. It theorizes that the quantitative changes of “blood stasis” are related to peripheral circulatory insufficiency. When chronic qualitative changes of “blood stasis” produce stagnant blood that turns into a pathological product, it could cause inflammation and lead to organic changes. Trauma induced hematomas, that are considered to be a quantitative change of blood, are also a form of blood stasis. The basic medicine research on Keishibukuryogan (KBG)–a Japanese name in Traditional Japanese Medicine (Kampo) for one of the most common anti- “blood stasis” prescriptions, also known as gui-zhi-fu-ling-wan (GFW) in Chinese in Traditional Chinese Medicine (TCM)–indicated that the initiation of quantitative changes was closely related to loss of redox balances on endothelial function induced by oxidative stress. The following qualitative changes were related to coagulopathy, hyper viscosity; anti-platelet aggregation, lipid metabolism; a regulation of systemic leptin level and/or lipid metabolism, inflammatory factor; cyclooxygenase-1,2 (COX-1, 2), interleukin-6, 8 tumor necrosis factor-α, macrophage infiltration, hyperplasia, tissue fibrosis and sclerosis caused by transforming growth factor-β1 and fibronectin, the dysfunction of regulated cell deaths, such as, apoptosis, autophagy, ferroptosis and ovarian hormone imbalance. Clinically, KBG was often used for diseases related to Obstetrics and Gynecology, Endocrine Metabolism, Rheumatology and Dermatology. In this review, we give an overview of the mechanism and its current clinical application of KBG through a summary of the basic and clinical research and discuss future perspective.

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Traumatic lateral abdominal wall hematoma treated with Kampo medicines

Cited by 9 publications

References 6 publications

Traumatic asphyxia successfully treated with jidabokuippo

Traumatic asphyxia successfully treated with jidabokuippo

Application of Traditional Japanese Drug Jidabokuippo in a Modern Society

A Review on the Mechanism and Application of Keishibukuryogan

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