Traumatic muscle injury

Edouard, Pascal; Reurink, Gustaaf; Mackey, Abigail L.; Lieber, Richard L.; Pizzari, Tania; Järvinen, Tero A. H.; Gronwald, Thomas; Hollander, Karsten

doi:10.1038/s41572-023-00469-8

Cited by 16 publications

(3 citation statements)

References 251 publications

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“…This first injury may be very difficult to avoid, and it would be of interest to implement a global rehabilitation approach to reduce sequelae and recurrent injuries for the rest of the athlete’s career. Therefore, these results could support a call to improve the management of the very first injuries, based on the available evidence, for example, muscle injuries,30 ankle sprains,31 tendinopathies,32 or bone stress injuries 33. Better education for the athlete and their team (eg, coach, family) about their injuries could also help limit career cessation due to an injury 34–36…”

Section: Discussionmentioning

confidence: 82%

Understanding the first injury in athletics and its effect on dropout from sport: an online survey on 544 high-level youth and junior athletics (track and field) athletes

Edouard,

Mosser,

Chapon

et al. 2024

BMJ Open Sport Exerc Med

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ObjectiveTo describe the first injury and to investigate whether it plays a role in altering athletics’ sustainable practice.MethodsWe conducted a cross-sectional study using an exploratory survey on the first injury and its consequences on athletics practice. In 2021, we asked all high-level athletes licensed with the French Federation of Athletics (FFA) under 18 years, under 20 years and under 23 years categories between 2007 and 2021.ResultsOut of 6560 emails sent by FFA, 544 athletes responded, and 93.6% (n=510) reported experiencing at least one injury during their career. The first injury occurred at a mean age of 17.5±3.3 years after 6.1±4.1 years of athletics practice. The main locations of the first injury were the posterior thigh (28.9%), the ankle (16.5%) and the knee (12.6%), and the principal reported injury types were muscle (37.7%), tendon (17.5%) and ligament (15.5%). More than a third of injured athletes (36.7%) reported experiencing ongoing symptoms or sequelae after their first injury, and about half (48.5%) experienced recurrences. About 20% had stopped athletics at the time of the survey, with injury problems the primary cause of athletes dropping out (46.2%), including the first injury (9.4%).ConclusionsInjuries played an important role in altering sustainable athletics practice, with injury accounting for about 50% of all reported dropouts and the first injury accounting for about 10% of all reported causes. Our results provide evidence to target the prevention of the first injury, which could be considered the origin of the ‘vicious circle’ of injuries.

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Section: Discussionmentioning

confidence: 82%

Understanding the first injury in athletics and its effect on dropout from sport: an online survey on 544 high-level youth and junior athletics (track and field) athletes

Edouard,

Mosser,

Chapon

et al. 2024

BMJ Open Sport Exerc Med

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“…These injuries can result from direct mechanical trauma or indirect causes such as vascular and neurological dysfunction [ 42 ]. Following a muscle injury, satellite cells within the muscle are activated, initiating processes like proliferation, differentiation, and fusion to form regenerated muscle fibers, showcasing the muscle’s robust regenerative capacity [ 43 , 44 ]. However, effective muscle regeneration necessitates intricate interactions among satellite cells, endothelial cells, immune cells, FAPs, and various cytokines secreted by non-muscular tissue-derived cells [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

miR-27b-3p reduces muscle fibrosis during chronic skeletal muscle injury by targeting TGF-βR1/Smad pathway

Yao,

Qian,

Bian

et al. 2024

J Orthop Surg Res

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Background Fibrosis is a significant pathological feature of chronic skeletal muscle injury, profoundly affecting muscle regeneration. Fibro-adipogenic progenitors (FAPs) have the ability to differentiate into myofibroblasts, acting as a primary source of extracellular matrix (ECM). the process by which FAPs differentiate into myofibroblasts during chronic skeletal muscle injury remains inadequately explored. Method mouse model with sciatic nerve denervated was constructed and miRNA expression profiles between the mouse model and uninjured mouse were analyzed. qRT/PCR and immunofluorescence elucidated the effect of miR-27b-3p on fibrosis in vivo and in vitro. Dual-luciferase reporter identified the target gene of miR-27b-3p, and finally knocked down or overexpressed the target gene and phosphorylation inhibition of Smad verified the influence of downstream molecules on the abundance of miR-27b-3p and fibrogenic differentiation of FAPs. Result FAPs derived from a mouse model with sciatic nerves denervated exhibited a progressively worsening fibrotic phenotype over time. Introducing agomiR-27b-3p effectively suppressed fibrosis both in vitro and in vivo. MiR-27b-3p targeted Transforming Growth Factor Beta Receptor 1 (TGF-βR1) and the abundance of miR-27b-3p was negatively regulated by TGF-βR1/Smad. Conclusion miR-27b-3p targeting the TGF-βR1/Smad pathway is a novel mechanism for regulating fibrogenic differentiation of FAPs. Increasing abundance of miR-27b-3p, suppressing expression of TGF-βR1 and inhibiting phosphorylation of smad3 presented potential strategies for treating fibrosis in chronic skeletal muscle injury.

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“…In addition to maintaining normal movement, skeletal muscle serves as the largest metabolic organ, regulating energy metabolism by secreting regulatory factors and communicating with distal organs [ 1 , 2 ]. However, it is sensitive to injury or disease, either from direct wounds or indirect causes such as congenital genetic defects, which can ultimately impact health [ 3 , 4 , 5 ]. If not repaired in time, the damage may lead to reduced muscle mass and impaired exercise capacity.…”

Section: Introductionmentioning

confidence: 99%

Regulation of myo-miR-24-3p on the Myogenesis and Fiber Type Transformation of Skeletal Muscle

Fan,

Yao,

Liu

et al. 2024

Genes

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Skeletal muscle plays critical roles in providing a protein source and contributing to meat production. It is well known that microRNAs (miRNAs) exert important effects on various biological processes in muscle, including cell fate determination, muscle fiber morphology, and structure development. However, the role of miRNA in skeletal muscle development remains incompletely understood. In this study, we observed a critical miRNA, miR-24-3p, which exhibited higher expression levels in Tongcheng (obese-type) pigs compared to Landrace (lean-type) pigs. Furthermore, we found that miR-24-3p was highly expressed in the dorsal muscle of pigs and the quadriceps muscle of mice. Functionally, miR-24-3p was found to inhibit proliferation and promote differentiation in muscle cells. Additionally, miR-24-3p was shown to facilitate the conversion of slow muscle fibers to fast muscle fibers and influence the expression of GLUT4, a glucose transporter. Moreover, in a mouse model of skeletal muscle injury, we demonstrated that overexpression of miR-24-3p promoted rapid myogenesis and contributed to skeletal muscle regeneration. Furthermore, miR-24-3p was found to regulate the expression of target genes, including Nek4, Pim1, Nlk, Pskh1, and Mapk14. Collectively, our findings provide evidence that miR-24-3p plays a regulatory role in myogenesis and fiber type conversion. These findings contribute to our understanding of human muscle health and have implications for improving meat production traits in livestock.

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Traumatic muscle injury

Cited by 16 publications

References 251 publications

Understanding the first injury in athletics and its effect on dropout from sport: an online survey on 544 high-level youth and junior athletics (track and field) athletes

Understanding the first injury in athletics and its effect on dropout from sport: an online survey on 544 high-level youth and junior athletics (track and field) athletes

miR-27b-3p reduces muscle fibrosis during chronic skeletal muscle injury by targeting TGF-βR1/Smad pathway

Regulation of myo-miR-24-3p on the Myogenesis and Fiber Type Transformation of Skeletal Muscle

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