Traumatic neuroma of the penis after circumcision - Case report

Cardoso, Thaís Abrão; Santos, Karen Regina dos; Franzotti, Aline Martinez; Avelar, Juliana Centofanti Dentello; Tebcherani, Antônio José; Pegas, José Roberto Pereira

doi:10.1590/abd1806-4841.20153233

Cited by 8 publications

(12 citation statements)

References 7 publications

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“…Traumatic neuroma involves the regenerative proliferation of injured or traumatized nerve fibers. A palisade-encapsulated neuroma is a hamartomatous proliferation of nerve tissue with no apparent preceding injury 2 . Traumatic neuromas are characterized clinically as solid papules or nodules, and the surgical scars or amputated lesions are skin colored or erythematous-purplish in appearance 2 .…”

Section: Discussionmentioning

confidence: 99%

“…A palisade-encapsulated neuroma is a hamartomatous proliferation of nerve tissue with no apparent preceding injury 2 . Traumatic neuromas are characterized clinically as solid papules or nodules, and the surgical scars or amputated lesions are skin colored or erythematous-purplish in appearance 2 . The initial lesions usually begin with no specific symptoms, but pain or paresthesia can develop during the course of months to years after onset.…”

Section: Discussionmentioning

confidence: 99%

“…It forms a nodular proliferation arising from the hyperplasia of axons and nerve sheaths after nerve injury or resection 1, 2, 3. Traumatic neuroma is a disorganized growth of the proximal portion of an injured or resected nerve; it can occur in any lesion, but few have been reported in the penis 2 . Most reported cases of traumatic neuroma in the penis have been associated with unintended trauma to the nerve during circumcision 3 .…”

Section: Introductionmentioning

confidence: 99%

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Penile Traumatic Neuroma: A Late Complication of Penile Dorsal Neurotomy to Treat Premature Ejaculation

et al. 2016

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IntroductionTraumatic neuroma is a reactive process caused by the regeneration of an injured nerve that usually forms a nodular proliferation of small nerve bundles. Penile traumatic neuroma is rare; only a few cases related to circumcision have been reported.AimTo report on a case of traumatic neuroma in the penis after selective dorsal neurotomy (SDN) to treat premature ejaculation.MethodsThe penile traumatic neuroma was successfully removed by excision and confirmed by histopathology.ResultsA 55-year-old man who had had several painless, slow-growing nodules on his penis for 2 years presented to our hospital. He had no history of genital trauma, urinary tract infection, or penile surgery, except SDN to treat premature ejaculation. The nodules were excised and the final diagnosis was traumatic neuroma. No recurrence has been detected during 1 year of follow-up.ConclusionThe main complications of SDN are recurrence of premature ejaculation, pain or paresthesia on the glans penis, and erectile dysfunction. However, no traumatic neuroma has been reported as a complication. We report that a traumatic neuroma can occur after SDN.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Penile Traumatic Neuroma: A Late Complication of Penile Dorsal Neurotomy to Treat Premature Ejaculation

et al. 2016

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“…The normal reparative process of the damaged nerve is disrupted leading to a disorganised exuberant proliferation of axons and nerve sheath cells. 22 When found on the penis they are commonly associated with unintended nerve injury during circumcision but may occur following any form of trauma. Histologically, these non-neoplastic lesions show a disorganised proliferation of nerve fascicles, Schwann cells and fibroblasts normally encased within a collagenous or myxoid stroma ( Figure 6) with varying degrees of background chronic inflammation.…”

Section: Penile Traumatic Neuromamentioning

confidence: 99%

An overview of benign and premalignant lesions of the foreskin

Sewell

Oxley

2019

Diagnostic Histopathology

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The foreskin is a common surgical specimen encountered by the practising histopathologist. Therapeutic circumcisions are performed to treat both benign and neoplastic foreskin lesions. Penile intraepithelial neoplasia (PeIN) is the precursor lesion of penile squamous cell carcinoma (SCC). The World Health Organisation (WHO) classifies PeIN into two subtypes based on the association with Human Papillomavirus (HPV); these include differentiated and undifferentiated PeIN. These subtypes of PeIN can be differentiated by specific cytological and architectural characteristics. This review article will discuss these histological characteristics and highlight potential difficulties that may arise in diagnosing PeIN. Furthermore, it will also consider common benign and preneoplastic foreskin lesions that may be encountered when reporting the foreskin specimen.

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“…Traumatic neuromas are nerve sheath tumors in which the ratio of axons to Schwann cell fascicles is approximately equal 56,57. The condition results from regenerative proliferation of traumatized or injured nerve fibers 56,57.…”

Section: Diagnosismentioning

confidence: 99%

Penile warts: an update on their evaluation and management

Leung¹,

Barankin²,

Leong³

et al. 2018

DIC

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BackgroundPenile warts are the most common sexually transmitted disease in males. Clinicians should be familiar with the proper evaluation and management of this common condition.ObjectiveTo provide an update on the current understanding, evaluation, and management of penile warts.MethodsA PubMed search was completed in Clinical Queries using the key terms ‘penile warts’ and ‘genital warts’. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews.ResultsPenile warts are caused by human papillomavirus (HPV), notably HPV-6 and HPV-11. Penile warts typically present as asymptomatic papules or plaques. Lesions may be filiform, exophytic, papillomatous, verrucous, hyperkeratotic, cerebriform, fungating, or cauliflower-like. Approximately one-third of penile warts regress without treatment and the average duration prior to resolution is approximately 9 months. Active treatment is preferable to watchful observation to speed up clearance of the lesions and to assuage fears of transmission and autoinoculation. Patient-administered therapies include podofilox (0.5%) solution or gel, imiquimod 3.75 or 5% cream, and sinecatechins (polypheron E) 15% ointment. Clinician-administered therapies include podophyllin, cryotherapy, bichloroacetic or trichloroacetic acid, oral cimetidine, surgical excision, electrocautery, and carbon dioxide laser therapy. Patients who do not respond to first-line treatments may respond to other therapies or a combination of treatment modalities. Second-line therapies include topical/intralesional/intravenous cidofovir, topical 5-fluorouracil, and topical ingenol mebutate.ConclusionNo single treatment has been shown to be consistently superior to other treatment modalities. The choice of the treatment method should depend on the physician’s comfort level with the various treatment options, the patient’s preference and tolerability of treatment, and the number and severity of lesions. The comparative efficacy, ease of administration, adverse effects, cost, and availability of the treatment modality should also be taken into consideration.

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Traumatic neuroma of the penis after circumcision - Case report

Cited by 8 publications

References 7 publications

Penile Traumatic Neuroma: A Late Complication of Penile Dorsal Neurotomy to Treat Premature Ejaculation

Penile Traumatic Neuroma: A Late Complication of Penile Dorsal Neurotomy to Treat Premature Ejaculation

An overview of benign and premalignant lesions of the foreskin

Penile warts: an update on their evaluation and management

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