Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE)

Sivapathasundharam, B; Lavanya, S

doi:10.4103/0973-029x.39058

Cited by 9 publications

(16 citation statements)

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“…The pathogenesis of TUGSE still remains controversial. [ 17 ] Among all etiological factors, mucosal trauma[ 4 ] (external or internal physical, chemical; thermal or electrical) appears to be the major instigating factor of this lesion. Previous literature states that not all TUGSE lesions are induced by trauma.…”

Section: Review Of Literaturementioning

confidence: 99%

“…The inflammatory infiltrate in TUGSE exhibits sheets of atypical mononuclear cells (predominantly T-cell lymphocyte population), eosinophils, macrophages/histiocytes, and few plasma cells. [ 4 ] In earlier studies, immunohistochemistry revealed these atypical mononuclear cells to be belonging to the macrophage and myofibroblast lineage. More recent studies point toward the T lymphocytic function of these cells immunohistochemically, with positivity against all T-cell specific antigens.…”

Section: Review Of Literaturementioning

confidence: 99%

“…Various antigens include toxins, viral, microorganisms, endogeneous degradation products or foreign proteins. [ 3 4 ] On release of cytokines, the predominant cells of eosinophils and lymphocytes are recruited to the submucosal tissue. [ 4 7 ] However, previous studies suggest that the exact presence of eosinophils remains controversial, as most of the traumatic ulcers are devoid of eosinophilic infiltration.…”

Section: Review Of Literaturementioning

confidence: 99%

“…[ 1 2 ] Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a reactive benign and self-limiting lesion of the oral mucosa exhibiting puzzling pathogenesis. [ 3 4 5 ] This lesion was first suggested by Popoff (1956) in adults. [ 6 ] Shortly, this lesion was named as Riga-Fede disease in infants and children by Riga (1881) clinically and later, by Fede (1890) histologically.…”

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confidence: 97%

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Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited

et al. 2015

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Oral ulcers are a common symptom in clinical practice. Among various causative factors, different types of ulcers in oral cavity exist. Among this, traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) appears to be quite neglected by the clinicians due to the limited knowledge and awareness. On reviewing with a detailed approach to titles and abstracts of articles eliminating duplicates, 40 relevant articles were considered. Randomized studies, review articles, case reports and abstracts were included while conference papers and posters were excluded. Of importance, TUGSE cases been reported only to a minimal extent in the literature. Lack of its awareness tends to lead clinicians to a misconception of cancer. Thus, this particular lesion needs to be differentiated from other malignant lesions to provide a proper mode of treatment. The present article reviews various aspects of the TUGSE with emphasis on the clinical manifestation, pathogenesis, histological, and immunohistochemical study. This study provides the clinician contemporaries, a humble expansion to their knowledge of the disease, based on the searched literature, enabling a more comprehensive management of this rare occurrence.

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Section: Review Of Literaturementioning

confidence: 99%

Section: Review Of Literaturementioning

confidence: 99%

Section: Review Of Literaturementioning

confidence: 99%

mentioning

confidence: 97%

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Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited

et al. 2015

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“…Eosinophils also produce major basic protein, which causes tissue destruction. [9] It is most frequently diagnosed in patients aged between 30 and 50 years. It can also occur in infants as well as in elderly people.…”

Section: Case Reportmentioning

confidence: 99%

Traumatic ulcerative granuloma with stromal eosinophilia: A diagnostic dilemma?

Nagaraj¹,

Okade²,

Sinha³

et al. 2014

JCRI

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Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a slow growing reactive lesion that commonly aff ects the tongue. The pathogenesis of this lesion is obscure. Chronic irritation from traumatic agents is considered to be one of the contributing factors in most of the cases. It usually presents as an ulcer or an indurated submucosal mass. Histopathologically, it is characterized by eosinophilic infl ammatory infi ltrate penetrating into the submucosal layers degenerating the underlying muscle. It is important to recognize this mucosal entity as it has a close resemblance with malignancy of the oral cavity. The pathognomonic feature of TUGSE is that it resolves on its own after excisional biopsy. A 25-year-old Sudanese boy had reported to us with an ulceroproliferative growth in the left side of the mouth.

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