Traumatic uveitis in the mid-Atlantic United States

Abstract

PurposeThe purpose of this study was to conduct an in-depth analysis of traumatic uveitis in patients managed in a mid-Atlantic tertiary care center with the goal of better characterizing the clinical features and outcomes of this large and important subset of uveitis patients.MethodsThis was a retrospective, observational study comparing traumatic uveitis patients with nontraumatic uveitis patients seen at the University of Virginia, Charlottesville, VA, USA, from 1984 to 2014.ResultsFifty-four traumatic uveitis patients (55 eyes) were identified. The patient population was 70.4% male, 57.4% Caucasian, and 37.0% African American. Mean age at diagnosis was 31.2 years; mean duration of follow-up was 5.4 years; and mean number of visits to the clinic was 4. The most common treatment modality was local steroids (77.8%). Glaucoma was medically managed in eight patients (14.8%). Cataract surgery was performed in five patients (9.3%). Mean best-corrected visual acuity at baseline for traumatic uveitis patients was 0.33 logMAR (SD 0.42) at the initial visit and 0.16 logMAR (SD 0.33) at the final visit. Mean baseline intraocular pressure (IOP) in the traumatic uveitis group was 15.5 mmHg (SD 7.4) at the initial visit and 14.6 mmHg (SD 4.0) at the final visit. Patients in the traumatic uveitis cohort tended to have better visual outcomes than those in the nontraumatic uveitis cohort.ConclusionIn our series, traumatic uveitis patients tended to be young and male and present with unilateral disease, all findings consistent with other reports. Despite relatively good visual outcomes, the traumatic uveitis patients still experienced a high burden of disease, measured both in the number of clinic visits and duration of follow-up. Due to the young mean age of patients, these disease burdens and decreased quality of life are nontrivial, emphasizing the importance of careful management and prompt treatment of this subset of uveitis patients.

AAV-mediated expression of HLA-G1/5 reduces severity of experimental autoimmune uveitis

“…Uveitis remains a significant cause of vision loss in humans with approximately 30,000 new cases diagnosed each year in the Unites States alone 28,29 . Non-infectious uveitis (NIH), which is the most common type of uveitis in the United States (prevalence of 121 cases in 100,000 adults, and 129 cases in 100,000 juveniles), is recurrent in its nature and can result in secondary complications such as cataracts, corneal opacities, glaucoma, and blindness 18,30 .…”

Traumatic Iritis: A Case Study

“…1 Traumatic forces shear uveal layers, releasing proinflammatory cytokines. 2 The inflammation can cause physical breakdown of blood-aqueousbarrier, releasing white blood cells (cells), protein (flare), and/ or red blood cells into the anterior chamber. 2 Damage to the circular and longitudinal muscles of the ciliary body leads to impaired trabecular meshwork, resulting in transient decrease in IOP.…”

“…It accounts for 20% of all iritis cases, presents unilaterally, and has a predilection for young males. 1,2 A thorough history and examination is required to uncover the mechanism of injury and whether additional testing is needed to rule out other uveitides. 1 Traumatic iritis can lead to long term complications, such as an irregular pupil, secondary glaucoma, cataract, and macular edema.…”

Pickleball Associated Abrasion and Iritis: A Case Study

“…As with general ocular trauma, traumatic uveitis occurs more frequently in young males. 25 Traumatic iritis comprises 20% of all uveitis cases, 26 and can be a damaging condition, leading to the formation of synechia, as well as causing damage to the drainage system and potential glaucoma.…”