PurposeUnderpinned by sensation-seeking theory (SST) and regulatory focus theory (RFT), this paper highlights the crucial role of adventurousness in self-protective behavior and future travel avoidance. Furthermore, this paper investigates safety-seeking tendency as a moderator and travel anxiety post-COVID-19 as a mediator.Design/methodology/approachData were gathered from 574 potential visitors to St. Catherine post-COVID-19 and analyzed using Smart-PLS approach.FindingsAdventurousness negatively and significantly affected travel anxiety, while the latter negatively influenced self-protective behavior and positively influenced future travel avoidance. Besides, the findings proved that travel anxiety partially mediated the adventurousness linkage with self-protective behavior and future travel avoidance. Moreover, safety-seeking tendencies dampened travel anxiety's connection with self-protective behavior and future travel avoidance.Practical implicationsThis paper provides valuable insights into travel research in theory and practice to revive tourist attractions post-COVID-19 in developing countries via an adventure tourism pattern. The study helps figure out how to deal with the pandemic and restore the monument of heavenly religions, St. Catherine—sacred mountain peaks, mosques, churches and many monasteries—in addition to its charming and picturesque nature.Originality/valueThe current paper examines a traveler's adventurous nature and post-COVID-19 behavior when visiting St. Catherine and their behaviors related to future avoidance and self-protection. This paper adds the first investigation of travel anxiety and safety-seeking through the lens of SST and RFT theories in the Egyptian tourism context.