Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports

Berardis, Domenico De; Fornaro, Michele; Ventriglio, Antonio; Valchera, Alessandro; Vellante, Federica; Pettorruso, Mauro; Martinotti, Giovanni; Fraticelli, Silvia; Giannantonio, Massimo Di

doi:10.9758/cpn.2021.19.4.780

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…A recent case study has reported that healthcare workers, veterans, and children may currently be particularly vulnerable to PTSD and stress- or fear-related disorders due to the COVID-19 pandemic [ 98 ]. In addition, there have been reports of successful cases of anxiety and stress relief by prescribing therapeutic drugs to such individuals [ 99 , 100 ]. However, the research on neurocircuitry approaches in the relationship between the COVID-19 pandemic and fear-related disorders remains inadequate.…”

Section: Discussionmentioning

confidence: 99%

Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits

Park

Cai

Yang

2022

IJMS

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Fear memory helps animals and humans avoid harm from certain stimuli and coordinate adaptive behavior. However, excessive consolidation of fear memory, caused by the dysfunction of cellular mechanisms and neural circuits in the brain, is responsible for post-traumatic stress disorder and anxiety-related disorders. Dysregulation of specific brain regions and neural circuits, particularly the hippocampus, amygdala, and medial prefrontal cortex, have been demonstrated in patients with these disorders. These regions are involved in learning, memory, consolidation, and extinction. These are also the brain regions where new neurons are generated and are crucial for memory formation and integration. Therefore, these three brain regions and neural circuits have contributed greatly to studies on neural plasticity and structural remodeling in patients with psychiatric disorders. In this review, we provide an understanding of fear memory and its underlying cellular mechanisms and describe how neural circuits are involved in fear memory. Additionally, we discuss therapeutic interventions for these disorders based on their proneurogenic efficacy and the neural circuits involved in fear memory.

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Section: Discussionmentioning

confidence: 99%

Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits

Park

Cai

Yang

2022

IJMS

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“…To our knowledge, this is the first report of the use of trazodone in people with cannabis use disorder. Some recent studies suggested that selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors, and the SARI classes of antidepressants drove this protective effect on COVID-19 infection risk [ 32 , 33 ]. Furthermore, it has been shown that during the COVID-19 pandemic—specifically in the 13 weeks following March 4, 2020—there were increased prescriptions in adult patients for trazodone, and decreased prescriptions for benzodiazepines and hypnotics [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Trazodone Prolonged-Release Monotherapy in Cannabis Dependent Patients during Lockdown Due to COVID-19 Pandemic: A Case Series

Mazza

Caroppo

Marano

et al. 2022

IJERPH

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(1) Background: During the SARS-CoV-2 (COVID-19) pandemic, cannabis use increased relative to pre-pandemic levels, while forced home confinement frequently caused sleep/wake cycle disruptions, psychological distress, and maladaptive coping strategies with the consequent appearance of anxiety symptoms and their potential impact on substance use problems. (2) Aim: Long-acting trazodone (150 mg or 300 mg daily) has a potential benefit as monotherapy in patients with cannabis use disorder. The present work aims to investigate the effectiveness of trazodone in optimizing the condition of people with cannabis dependence under pandemic conditions. (3) Methods: All cases with cannabis use disorder were uniformly treated with long-acting trazodone 150 mg or 300 mg/day; their craving and clinical status were monitored through appropriate psychometric scales. Side effects were recorded as they were reported by patients. We described the cases of three young patients—one man and two women—who were affected by chronic cannabis use disorder and who experienced lockdown-related psychological distress and sought psychiatric help. (4) Results: The described cases highlight that the once-a-day formulation of trazodone seems to have a therapeutic role in patients with cannabis use disorder and to guarantee tolerability and efficacy over time. No significant side effects emerged. (5) Conclusions: The use of long-acting trazodone (150 mg or 300 mg daily) has a potential benefit as monotherapy in patients with cannabis use disorder. Trazodone deserves to be studied in terms of its efficacy for cannabis use disorder.

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“…Second, unobserved variables, such as personal experience and traits, could also affect JD-R, burnout, and psychological distress. For example, studies have shown that burnout might be related to post-traumatic stress symptoms, temperament, alexithymia, and resilience ( 60 , 61 ). Because these were not included in our model, they may have unknown effects on the estimates from our analysis.…”

Section: Discussionmentioning

confidence: 99%

Job Demands and Resources, Burnout, and Psychological Distress of Employees in the Chinese Non-profit Sector

et al. 2021

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The non-profit sector in China has expanded significantly in the past few decades. However, employees in non-profits experience high burnout rates, indicating a need to study non-profit work conditions and their effect on employees. This study applies the job demands and resources (JD-R) model and examines the effects of job demands (JD) and job resources (JR) on burnout and psychological distress experienced by non-profit employees, recruited via quota sampling, across China (n = 233). The findings from path analysis showed that JR had strong and negative effects on burnout and on psychological distress, while JD had strong and positive effects on burnout and on psychological distress. Burnout partially mediated the relations between JD-R and psychological distress. These results highlight the importance of JD-R in reducing burnout and psychological distress in non-profit employees in China. Research and practice implications are discussed.

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Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports

Cited by 14 publications

References 42 publications

Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits

Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits

Trazodone Prolonged-Release Monotherapy in Cannabis Dependent Patients during Lockdown Due to COVID-19 Pandemic: A Case Series

Job Demands and Resources, Burnout, and Psychological Distress of Employees in the Chinese Non-profit Sector

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