Trazodone for the Treatment of Neuroleptic-Induced Acute Akathisia

Abstract

The findings of this double-blind, placebo-controlled, crossover study indicate the efficacy of Trz in the management of NIA, corroborating the results of a preliminary pilot study. We suggest that Trz's property of serotonin 2A postsynaptic receptor antagonism may be its principal mechanism for the improvement of NIA.

Vergiftungen mit psychotropen Substanzen

“…Amantadin, Benzodiazepine oder Propranolol stellen Alternativen dar [10]. Bei akuter Akathisie ist Trazodon mit Erfolg verabreicht worden [15]. Bei neuroleptikainduzierter maligner Hyperthermie, die allerdings dosisunabhängig auftreten kann, kann eine mechanische Kühlung erforderlich werden.…”

Treatment of Antipsychotic-Related Akathisia Revisited

“…In addition, a limitation of current evidence is that 21 Conversely, there were no changes in akathisia ratings when trazodone was switched to placebo after 3 days of treatment. 22 Longer prospective investigations are needed to clarify the adequate duration of treatment with a 5-HT2A antagonist as an antiakathisia agent. In addition, the effective dose range of 5-HT2A antagonists should be addressed in future studies.…”

Pharmacological management of antipsychotic-induced akathisia: an update and treatment algorithm

“…The MEDLINE search found a number of small randomised controlled trials investigating other akathisia treatments, including trazodone (Stryjer 2010), vitamin B 6 (Lerner 2004;Miodownik 2006) and mianserin (Poyurovsky 1999), each of which demonstrated therapeutic benefit. However, there appears to be a growing body of data suggesting that mirtazapine, a presynaptic α 2 receptor and specific serotonin antagonist, may have a greater role to play in the management of akathisia.…”