Trazodone-induced delirium: case report

Pereira, Ana Teresa; Mota, Dálete Delalibera Corrêa de Faria; Ribeiro, Leonardo Costa; Rodrigues, José Daniel

doi:10.1016/j.rcpeng.2018.10.013

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Trazodone (TZD) is an antidepressant drug that belongs to the class of serotonin antagonist and reuptake inhibitor [ 2 , 7 , 8 , 9 ]. It is a triazolopyridine derivate and presents antidepressant, anxiolytic, and hypnotic effects, but produces lower anticholinergic side effects than other antidepressants [ 10 ]. TZD was first authorized in the 1970s for the treatment of depression.…”

Section: Introductionmentioning

confidence: 99%

Electropolymerized, Molecularly Imprinted Polymer on a Screen-Printed Electrode—A Simple, Fast, and Disposable Voltammetric Sensor for Trazodone

Seguro

Rebelo

Pacheco

et al. 2022

Sensors

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In recent years, analytical chemistry has been facing new challenges, particularly in developing low-cost, green, and easy-to-reproduce methods. In this work, a simple, reproducible, and low-cost electrochemical (voltammetric) molecularly imprinted polymer (MIP) sensor was designed specifically for the detection of trazodone (TZD). Trazodone (TZD) is an antidepressant drug consumed worldwide since the 1970s. By combining electropolymerization (surface imprinting) with screen-printed electrodes (SPCEs), the sensor is easy to prepare, is environmentally friendly (uses small amounts of reagents), and can be used for in situ analysis through integration with small, portable devices. The MIP was obtained using cyclic voltammetry (CV), using 4-aminobenzoic acid (4-ABA) as the functional monomer in the presence of TZF molecules in 0.1 M HCl. Non-imprinted control was also constructed in the absence of TZD. Both polymers were characterized using CV, and TZD detection was performed with DPV using the oxidation of TZD. The polymerization conditions were studied and optimized. Comparing the TZD signal for MIP/SPCE and NIP/SPCE, an imprinting factor of 71 was estimated, indicating successful imprinting of the TZD molecules within the polymeric matrix. The analytical response was linear in the range of 5–80 µM, and an LOD of 1.6 µM was estimated. Selectivity was evaluated by testing the sensor for molecules with a similar structure to TZD, and the ability of MIP/SPCE to selectively bind to TZD was proven. The sensor was applied to spiked tap water samples and human serum with good recoveries and allowed for a fast analysis (around 30 min).

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