Treadmill running starting 3 months after orchidectomy restores femoral bone mass in rats

Horcajada-Molteni, M.N.; Davicco, Marie-Jeanne; Coxam, Véronique; Lebecque, Patrice; Dominguez, B. Liza; Ritz, Patrick; Culioli, Joseph; Barlet, J.P.

doi:10.1007/s004210050503

Cited by 13 publications

(18 citation statements)

References 54 publications

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“…3), a marker of bone resorption (Robins 1994). Similar eect of endurance running upon bone metabolism have been previously reported in male rats (Horcajada et al 1997;Horcajada-Molteni et al 1999). Concerning BMD, exercise had no immediate eect on femoral density: total diaphyseal or metaphyseal density was no dierent in IE and IR.…”

Section: Discussionsupporting

confidence: 74%

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Does endurance running before orchidectomy prevent osteopenia in rats?

Horcajada-Molteni¹,

Davicco²,

Collignon³

et al. 1999

Eur J Appl Physiol

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This experiment was performed to study the effects on femoral bone of endurance training performed during the 3 months before orchidectomy in rats which were then killed 90 days later. A total of 70 male Wistar rats were used at 8 weeks old. One day 0 of the experiment, 10 rats were killed by cervical dislocation and used as first controls. Among the 60 others, 30 were selected for treadmill running (60% maximal oxygen uptake, 1 h x day(-1), 6 days x week(-1) for 90 days). The 30 other rats remained at rest. On day 90, 10 exercised (IE) and resting (IR) rats were killed and used as intermediary controls. Among the 20 other animals of each group, 10 were surgically castrated (CXE, CXR) or 10 sham-operated (SHE, SHR) and killed on day 180. On day 90 femoral failure load (three-point bending test) was greater in IE than in IR. Simultaneously, the deoxypyridinolinuria was lower in IE than in IR. On day 180, femoral bones were thinner in CXR than in CXE. The lowest values for trabecular bone are in the distal femoral metaphysis were measured in CXE and CXR rats, but the value measured in CXE was no different from that measured in SHR. Simultaneously total femoral bone density was lower in CXR than in SHE, while no difference concerning femoral metaphyseal density was observed between CXE and SHR. These results confirmed that endurance running increased femoral bone growth and modelling and femoral trabecular area, and thereby peak bone mass, in 8-month-old male rats. In resting animals, castrated after the training period, androgen deficiency decreased femoral density, mineral content and trabecular area. This decrease was not observed in castrated but previously exercised rats. Thus, by increasing peak bone mass, it was considered that endurance training may have a preventive effect against orchidectomy-induced bone loss.

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Section: Discussionsupporting

confidence: 74%

“…In the same way, endurance training, starting only 3 months after orchidectomy, also restores femoral bone density and mineral content in rats (Horcajada-Molteni et al 1999). However, is endurance running, performed during the 3 months before orchidectomy, able to prevent androgenic de®ciency-induced bone loss?…”

Section: Introductionmentioning

confidence: 88%

Does endurance running before orchidectomy prevent osteopenia in rats?

Horcajada-Molteni¹,

Davicco²,

Collignon³

et al. 1999

Eur J Appl Physiol

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“…In men, Stepan et al (25) reported an increase in bone turnover and a rapid decrease in lumbar spine BMD in response to orchidectomy. In growing (10,11,28) and aged or mature ORX rats (5,24,27,31,32), previous studies have also been suggested that androgen deficiencyinduced cancellous bone loss is, at least transiently, associated with increased bone formation and resorption. Bone development was inhibited immediately after orchidectomy in growing rats (27,28) but not rapidly in mature rats (4).…”

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confidence: 98%

Effects of tower climbing exercise on bone mass, strength, and turnover in orchidectomized growing rats

Notomi

Okazaki

Okimoto

et al. 2002

Journal of Applied Physiology

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To determine the effects of a tower climbing exercise on mass, strength, and local turnover of bone, 70 9-wk-old Sprague-Dawley rats were assigned to seven groups: a baseline control and three groups of sham-operated sedentary, orchidectomized (ORX)-sedentary and ORX-exercise rats. Rats voluntarily climbed a 200-cm tower to drink water from a bottle set at the top. At 4 wk, the periosteal bone formation rate (BFR), moment of inertia, bone mineral content, bone mineral density, and bending load at the midfemur were maintained in ORX-exercise rats, whereas these parameters were reduced in ORX-sedentary rats. At 8 wk, the periosteal mineral apposition rate and BFR in ORX-exercise rats were significantly higher, whereas the parameters in ORX-sedentary rats did not differ compared with sham-sedentary rats. In ORX-exercise rats, the trabecular mineralizing surface, BFR, and bone volume of the lumbar vertebrae were maintained at the same levels as those in the sham-sedentary group, whereas the osteoclast surface decreased compared with the ORX-sedentary group. However, the climbing exercise did not affect bone mineral content, bone mineral density, or the compression load of the lumbar vertebrae. These results show that, in the midfemur, the voluntary climbing exercise maintained cortical bone mass and strength by stimulating periosteal bone formation and partially prevented ORX-induced trabecular bone loss, depressing the elevation of turnover. Interestingly, in ORX rats, the climbing exercise had the opposite effect on bone formation at the periosteal femoral cortical bone, where the exercise increased the bone formation compared with vertebral trabecular bone, where the exercise decreased it.

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“…In our study as well, we discovered that mirtazapine, which is a norepinephrine and specific serotonergic antidepressant, has a negative influence on BMD and reduces the mechanical strength of bones in the femoral neck region. In rodents, physical activity prevents decreases in BMD as it does in humans, which suggests that increased physical activity could be useful in the prevention of bone mineral loss, regardless of gonadal hormone deficiency [16]. Therefore, reduced locomotor activity could be the factor contributing to the significant decrease in BMD in the left and right femurs in the ORX MIRTA group compared with the ORX group.…”

Section: Discussionmentioning

confidence: 99%

Effect of Mirtazapine on Rat Bone Tissue after Orchidectomy

Fekete

Simko²,

Mzik³

et al. 2015

Pharmacology

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Objective: Our study aimed to investigate the effect of mirtazapine on bone metabolism in the orchidectomized rat model. Methods: Rats were divided into three groups. A sham-operated control group (SHAM group) and a control group after orchidectomy (ORX group) received the standard laboratory diet (SLD). An experimental group after orchidectomy (ORX MIRTA group) received SLD enriched with mirtazapine for 12 weeks. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Bone marker concentrations of osteoprotegerin (OPG), amino-terminal propeptide of procollagen type I, bone alkaline phosphatase (BALP), sclerostin and bone morphogenetic protein 2 were examined in bone homogenate. The femurs were used for biomechanical testing. Results: Compared with the control ORX group, we found a lower BMD in the ORX MIRTA group. The differences were statistically significant, although not in the lumbar vertebrae. BMD was lower in the MIRTA group, suggesting a preferential effect on cortical bone. However, although the thickness of the diaphyseal cortical bone was not different, the fragility in the femoral neck area was statistically significantly different between the groups in biomechanical testing. Regarding the bone metabolism markers, there was a significant decrease in OPG and BALP levels, suggesting a reduction in osteoid synthesis. Conclusions: The results suggest that prolonged use of mirtazapine may have a negative effect on the synthesis of bone and on its mechanical strength, especially in the femoral neck. Further studies are warranted to establish whether mirtazapine may have a clinically significant adverse effect on bone exclusively in the model of gonadectomized rats, or whether the effect occurs also in the model of gonadally intact animals and in respective human models.

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Treadmill running starting 3 months after orchidectomy restores femoral bone mass in rats

Cited by 13 publications

References 54 publications

Does endurance running before orchidectomy prevent osteopenia in rats?

Does endurance running before orchidectomy prevent osteopenia in rats?

Effects of tower climbing exercise on bone mass, strength, and turnover in orchidectomized growing rats

Effect of Mirtazapine on Rat Bone Tissue after Orchidectomy

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