Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum

Leyton-Carcaman, Benjamín; Ramos, Juliana Nunes; Baio, Paulo Victor Pereira; Veras, João Flávio Carneiro; Souza, Cassius; Burkovski, Andreas; Mattos‐Guaraldi, Ana Luíza; Vieira, Verônica Viana; Abanto, Michel

doi:10.3390/ijms22147499

Cited by 23 publications

(26 citation statements)

References 90 publications

(178 reference statements)

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“…The dissemination of multidrug-resistant Corynebacterium species in the hospital environment affects the acquired resistance to β-lactam antimicrobials, clindamycin, erythromycin, ciprofloxacin, and gentamicin [18]. Currently, glycopeptides, linezolid, quinupristin/dalfopristin, daptomycin, and tigecycline are the effective drugs available against C. striatum clinical isolates [19][20][21]. Unfortunately, the literature is scarce and related to specific countries.…”

Section: Introductionmentioning

confidence: 99%

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Corynebacterium striatum—Got Worse by a Pandemic?

et al. 2022

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The role of Corynebacterium striatum has been demonstrated in different nosocomial infections. An increasing number of publications have demonstrated its virulence in the respiratory tract, especially in the immunosuppressed patient population. The number of these patients has increased significantly during the COVID-19 pandemic. For this reason, we aimed to investigate the prevalence and antimicrobial resistance pattern of this species between 2012 and 2021 at the Clinical Center of the University of Szeged, Hungary. Altogether, 498 positive samples were included from 312 patients during the study period. On the isolates, 4529 antibiotic susceptibility tests were performed. Our data revealed that the prevalence of C. striatum increased during the COVID-19 pandemic, the rise occurred in respiratory, blood culture, and superficial samples. During the study period, the rifampicin resistance significantly increased, but others have also changed dynamically, including linezolid. The species occurred with diverse and changing co-pathogens in the COVID-19 era. However, the increasing rifampicin and linezolid resistance of C. striatum was probably not due to the most commonly isolated co-pathogens. Based on resistance predictions, vancomycin is likely to remain the only effective agent currently in use by 2030.

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Section: Introductionmentioning

confidence: 99%

“…Unfortunately, the literature is scarce and related to specific countries. However, the increasing resistance is expected to be a key problem for the genus in the future [21].…”

Section: Introductionmentioning

confidence: 99%

Corynebacterium striatum—Got Worse by a Pandemic?

et al. 2022

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“…The plasmids in bacteria provide a positive platform to capture and spread a variety of ARG. In corynebacteria of clinical importance, several plasmids are known to confer resistance ( Deb and Nath, 1999 ; Leyton et al, 2021 ), such as pTP10 of C. striatum , pNG2 of Corynebacterium diphtheriae , and pJA144188 of Corynebacterium resistens . They also include a significant content of insertion sequences ( Tauch et al, 2003 ; Schröder et al, 2012 ), suggesting a relation between IS, plasmids, and C. striatum .…”

Section: Why Should Insertion Sequences Be An Epidemiological Descriptor?mentioning

confidence: 99%

“…Furthermore, this extends to other plasmids and other bacteria; for example, Che et al (2021) showed that IS contribute to the acquisition and transfer of ARG in conjugative plasmids. Regardless of the existence of plasmids, something that is quite clear is the relationship of IS with antibiotic resistance in C. striatum ( Wang et al, 2020 ; Leyton et al, 2021 ). Therefore, the increase in resistance in C. striatum strains would be mainly associated with these mobile elements.…”

Section: Why Should Insertion Sequences Be An Epidemiological Descriptor?mentioning

confidence: 99%

“…Resistance to antibiotics in C. striatum has been mainly associated with transposons and plasmids ( Olender, 2012 ) which are part of its resistome, i.e., the total repertoire of genes that contribute to resistance. Recently, the richness of the resistome in C. striatum has been evidenced, mainly associated with MGE, where the vast presence of IS in the genomic context of several ARGs was highlighted and underlined the importance of IS in the formation of the resistome in C. striatum ( Leyton et al, 2021 ). Whereas insertion sequences have been associated with genes that confer advantageous phenotypes, including resistance genes, studying and relating them could help to better understand the emergence, spread, and persistence of resistance in C. striatum , thus making the IS important epidemiological descriptors.…”

Section: Introductionmentioning

confidence: 99%

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Beyond to the Stable: Role of the Insertion Sequences as Epidemiological Descriptors in Corynebacterium striatum

Leyton-Carcaman

Abanto

2022

Front. Microbiol.

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In recent years, epidemiological studies of infectious agents have focused mainly on the pathogen and stable components of its genome. The use of these stable components makes it possible to know the evolutionary or epidemiological relationships of the isolates of a particular pathogen. Under this approach, focused on the pathogen, the identification of resistance genes is a complementary stage of a bacterial characterization process or an appendix of its epidemiological characterization, neglecting its genetic components’ acquisition or dispersal mechanisms. Today we know that a large part of antibiotic resistance is associated with mobile elements. Corynebacterium striatum, a bacterium from the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and nosocomial outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing worldwide. Despite the different existing mobile genomic elements, there is evidence that acquired resistance genes are coupled to insertion sequences in C. striatum. This perspective article reviews the insertion sequences linked to resistance genes, their relationship to evolutionary lineages, epidemiological characteristics, and the niches the strains inhabit. Finally, we evaluate the potential of the insertion sequences for their application as a descriptor of epidemiological scenarios, allowing us to anticipate the emergence of multidrug-resistant lineages.

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Coryneform Gram‐Positive Rods

Mattos‐Guaraldi,

Santos,

Vieira

2023

ClinMicroNow

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This chapter presents Coryneform bacteria comprising aerobically or facultatively anaerobically growing, asporogenous, non‐acid fast Gram‐positive rods with irregular morphology. Establishing the clinical significance of coryneform bacteria can be difficult for caregivers and microbiologists. Corynebacterium spp. form the predominant group and include diphtheria toxin (DT)‐producing Corynebacterium diphtheriae , the causative agent of classic diphtheria, which was once a major cause of illness and death among children. Laboratory procedures for identification of Corynebacterium spp. and other coryneform bacteria include collection and transport of clinical samples, isolation practices, culture conditions, phenotypic and molecular assays, as well as antimicrobial susceptibility testing. Molecular techniques have been increasingly used in microbiology laboratories for the identification of Corynebacterium species and other coryneform bacteria. Detection of antibodies directed against DT is the only established serologic test for coryneform bacteria.

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Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum

Cited by 23 publications

References 90 publications

Corynebacterium striatum—Got Worse by a Pandemic?

Corynebacterium striatum—Got Worse by a Pandemic?

Beyond to the Stable: Role of the Insertion Sequences as Epidemiological Descriptors in Corynebacterium striatum

Coryneform Gram‐Positive Rods

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