Treat-to-target familial hypercholesterolemia (TTT-FH): a prospective study in adult patients with FH. Women have many years off lipid lowering medication due to pregnancy

Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia

“…The estimated total length of pregnancy-related off-statin periods in the FH women who had a median of two children was a little more than two years. This finding is in line with Kusters et al who described two cases of FH women, where length of pregnancy-related off-statin periods was 15 and 30 months in two women who had given birth to one and two children, respectively [12], but shorter than the four years per child birth in 22 Norwegian FH patients reported by Arnesen et al [11]. As most Norwegian women breastfeed for less than one year, the four years off-treatment per child reported by Arnesen et al may have been due to longer off-treatment periods in planning pregnancy and after breastfeeding, or planning next pregnancy as most of the women had one child.…”

“…Little is known about how long FH women discontinue statin treatment in relation to pregnancy and breastfeeding periods. Only small studies and case reports have to our knowledge previously reported on pregnancy-related off-statin periods in FH women [11,12]. Elucidating these periods of interrupted treatment is therefore important for the management of FH in women of childbearing age.…”