Timely and important studies are reviewed and commentaries provided by leading palliative care clinicians. Symptoms, interventions, mechanisms of action, and treatment-related adverse events addressed in this issue are: analgesia in the management of the acute abdomen; comparative antibiotic treatment of Clostridium difficile; impact of weather on joint pain; treatment of constipation; and, risk of increased mortality with antipsychotics in dementia patients.