Treating Alzheimer's Dementia With CT-Induced Low-Dose Ionizing Radiation: Problematic, Yet Potential for More Precise Inquiry

Raynor, Stephanie; Giordano, James

doi:10.1177/1559325817729247

Cited by 5 publications

(8 citation statements)

References 7 publications

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“…near bone marrow) could be minimized or possibly avoided. In addition, the application of RT for the treatment of degenerative neurological diseases with significant inflammatory components, such as Alzheimer’s and Parkinson’s disease, is now being explored 54 –59 in several case studies and a phase 1 clinical trial. Likewise, recent papers suggest the utility of RT for different types of cancers, several autoimmune diseases, and diabetes.…”

Section: Resultsmentioning

confidence: 99%

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose

et al. 2019

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During the early part of the past century, hundreds of clinical studies involving more than 37,000 patients were conducted that showed radiotherapy (RT) to be a successful and safe alternative to drug therapy for the treatment of many diverse inflammatory conditions and diseases (e.g. tendonitis, bursitis, arthritis, and serious inflammatory lung conditions). Data from these studies were collected and analyzed with the intent of estimating an optimal dosing range for RT that would induce an efficacious treatment response. RT was reported to be frequently effective after only a single treatment, with a rapid (within 24 h) and often long-lasting (from months to years) relief from symptoms. Over a two-decade span from the 1920s to the 1940s, the therapeutic responses to a single RT treatment consistently improved as the dosing for multiple ailments decreased over time to between 30 roentgen (r) and 100 r. These findings are significant and in agreement with a number of contemporary reports from Germany where RT has been commonly and successfully employed in treating ailments with an inflammatory origin. A proposed mechanism by which RT mitigates inflammation and facilitates healing is via the polarization of macrophages to an anti-inflammatory or M2 phenotype.

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Section: Resultsmentioning

confidence: 99%

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose

et al. 2019

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“…Several case studies and phase 1 clinical trials are currently exploring the use of low-dose RT for the treatment of degenerative neurological diseases with major inflammatory aspects such as Alzheimer and Parkinson disease. 58 -63…”

Section: Current Use Of Low-dose Rt In Humansmentioning

confidence: 99%

Necrotizing Fasciitis: Low-Dose Radiotherapy as a Potential Adjunct Treatment

et al. 2019

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Necrotizing fasciitis (NF) is a rapidly spreading bacterial infection causing extensive tissue necrosis and destruction. Despite appropriate therapy, the disease results in significant morbidity/mortality and substantial treatment costs. Several studies published in the early 1900s demonstrated the effective use of low-dose X-ray radiotherapy (RT) for the treatment of many diverse inflammatory conditions and diseases (eg, gas gangrene, sinus infections, arthritis, tendonitis, and serious inflammatory lung conditions). The mechanism by which therapeutic RT doses produce positive patient outcomes is related at least in part to its capacity to induce tissue-based anti-inflammatory responses. This action is due to the polarization of macrophages to an anti-inflammatory or M2 phenotype via optimized low-dose RT. Low-dose RT has the potential to significantly reduce debilitating surgeries and aggressive treatments required for NF, providing a 3-prong benefit in terms of patient mortality, length of hospitalization stays, and cost of health care (both short term and long term). Low cost and easy availability of low-dose RT makes it a potentially useful option for patients of every age-group. In addition, low-dose RT may be a particularly useful option in countries treating many patients who are unable to afford surgeries, antibiotics, and hyperbaric oxygen.

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“…The commentary states that the case report “posits” that the CT scans ameliorated the AD symptoms. 1 It is well known that nonresponsive patients with advanced AD in hospice do not recover their appetite and responsiveness and are not discharged from hospice to an Alzheimer care home. Increased mobility and other positive changes were observed very soon after each CT scan.…”

Section: Specific Responses To Statements In the Commentarymentioning

confidence: 99%

“…It ignores them; it merely questions the idea that LDIR could stimulate adaptive protection systems in the brain. 1 …”

Section: Specific Responses To Statements In the Commentarymentioning

confidence: 99%

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Response to Commentary: Treating Alzheimer Dementia With CT-Induced Low-Dose Ionizing Radiation: Problematic, Yet Potential for More Precise Inquiry

Cuttler¹

2017

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Treating Alzheimer's Dementia With CT-Induced Low-Dose Ionizing Radiation: Problematic, Yet Potential for More Precise Inquiry

Cited by 5 publications

References 7 publications

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose

Necrotizing Fasciitis: Low-Dose Radiotherapy as a Potential Adjunct Treatment

Response to Commentary: Treating Alzheimer Dementia With CT-Induced Low-Dose Ionizing Radiation: Problematic, Yet Potential for More Precise Inquiry

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