Treating canine Cushing’s syndrome: Current options and future prospects

Sanders, Karin; Kooistra, Hans S.; Galac, Sara

doi:10.1016/j.tvjl.2018.09.014

Cited by 41 publications

(67 citation statements)

References 119 publications

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“…Debe tenerse en cuenta el estado de salud del paciente, la presencia de metástasis no resecables y la aparente capacidad de invasión del tumor (trombosis en vena cava caudal) a la hora de determinar la conveniencia de la cirugía de los tumores adrenales. En caso de que el tumor sea invasivo, es preferible el abordaje abdominal por la línea media para permitir la evaluación de la vena cava caudal y de las otras estructuras abdominales (Sanders et al, 2018).…”

Section: Discussionunclassified

“…Otras complicaciones que se pueden presentar según Mayhew (2014), son las hemorragias, los desequilibrios hídricos y electrolíticos, infección de las heridas y retraso de la cicatrización. El pronóstico de los perros con carcinoma adrenocorticales depende del tamaño del tumor y su capacidad de invasión, pudiendo tener una sobrevida de unos 36 meses (Sanders et al, 2018). Cuando la adrenalectomía no sea posible porque el tumor es de carácter maligno o el estado de salud de paciente no es adecuado, el tratamiento médico con ketoconazol, trilostano o mitotano podría ser una alternativa terapéutica (Sanders et al, 2018).…”

Section: Discussionunclassified

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Síndrome de Cushing en un paciente canino con carcinoma cortical adrenal: Reporte de un caso

Maurenzig

Cainzos

2021

Rev. investig. vet. Perú

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El objetivo de este trabajo fue resaltar la importancia del diagnóstico de la causa del síndrome de Cushing, en un paciente canino macho, de 12 años de edad, con carcinoma cortical adrenal, que llega a la consulta por presentar signos clínicos compatibles con Síndrome de Cushing. Los resultados de la estimulación con ACTH sintética (Synacthen 0.25 mg®) arrojaron un aumento en el cortisol basal (10.8 µg/dl) y pos-estimulación (28.4 µg/dl). La ecografía abdominal reveló la glándula adrenal izquierda de forma redondeada y aumentado de tamaño (3.3 x 3.4 cm), compatible con neoplasia adrenal. El tratamiento de elección fue la adrenalectomía de la glándula adrenal izquierda por abordaje abdominal en la línea media y posterior envío a histopatología para su evaluación, el cual confirmó un carcinoma cortical adrenal. La adrenalectomía en estos casos aumenta la supervivencia, mejorando así la calidad de vida del paciente.

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Section: Discussionunclassified

Síndrome de Cushing en un paciente canino con carcinoma cortical adrenal: Reporte de un caso

Maurenzig

Cainzos

2021

Rev. investig. vet. Perú

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“…Although clinical remission can be also observed in the idiopathic vestibular syndrome,11 the recurrence of vestibular signs with the reincorporation of trilostane (rapid start action, hours)21 allows the establishment of a direct role of this drug in the neurological signs of this patient.…”

Section: Discussionmentioning

confidence: 99%

Vestibular dysfunction due to thalamic metastasis of a corticotropic carcinoma in a dog

Arias

Trigo

Alvarez³

et al. 2020

Vet Record Case Reports

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Metastatic pituitary carcinoma and central vestibular syndrome originating in the thalamus are not common disorders in dogs. An 11-year-old Maltese dog with pituitary-dependent hypercortisolism presented signs of central vestibular dysfunction after trilostane treatment. Interestingly, the patient showed remission of vestibular signs after drug withdrawal, but two weeks later, with a new administration of trilostane, these signs reappeared after 48 hours. Postmortem, two neoplasms were found: one in the pituitary gland and the other in the thalamus, both with intense positivity for adrenocorticotropic hormone. Findings were conclusive of a functional corticotropic pituitary carcinoma with thalamic metastasis. Altogether, the vestibular dysfunction in this case was attributed to the effect of the mass in the thalamus, and the remission and reappearance of vestibular signs were associated with the level and the effect of cortisol, which depend on the trilostane therapy. Consequently, thalamic metastasis should be considered as a differential diagnosis in dogs with central vestibular dysfunction.

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“…Spontaneous hypercortisolism (HC), one of the most common endocrinopathies in dogs, induces a state of immunosuppression which increases susceptibility to infections. 11,13,15,36 As a result, dogs with HC often develop bacteriuria, comparable to dogs under long-term therapy with glucocorticoids or immunocompromised dogs. 12,16,37,38 According to current veterinary guidelines, the presence of bacteria in the urine determined by a positive bacterial culture, together with clinical signs (pollakisuria, dysuria, periuria, stranguria, hematuria), is defined as sporadic bacterial cystitis.…”

Section: Introductionmentioning

confidence: 99%

Urinary tract infections in dogs with spontaneous hypercortisolism – frequency, symptoms and involved pathogens

DuPont

Burkhardt

Boretti

et al. 2020

SAT

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Dogs with hypercortisolism are predisposed to developing bacteriuria associated either with clinical signs of cystitis or without clinical signs (subclinical bacteriuria). Based on current guidelines, dogs with subclinical bacteriuria should not be treated with antibiotics because there is no evidence that treatment improves outcome and because unnecessary treatments should be avoided. Before these guidelines were published in 2019, dogs with hypercortisolism and bacteriuria were commonly treated with antibiotics irrespective of clinical signs. Comprehensive data on the frequency of bacterial cystitis, subclinical bacteriuria and the outcome of antimicrobial treatment in dogs with hypercortisolism is sparse. The aims of this study were to investigate dogs with hypercortisolism for the presence of bacterial cystitis and subclinical bacteriuria, to address the pathogens involved, and to assess the outcome of antibiotic treatment. Dogs newly diagnosed with hypercortisolism between 2005 and 2015 from which a urine bacterial culture was available were included. Statistical analysis was performed with non-parametric tests. Of the 161 client-owned dogs included, 29 (18%) showed bacteriuria, which was subclinical in 24 (83%) cases. Escherichia coli was the most commonly isolated pathogen (58%). Bacteriuria was not associated with sex or neutering status. In 14 dogs, follow-up data was available, of which 13 (93%) were treated with antimicrobials for 14 to 28 days. Follow-up bacterial culture (1 to 118 days after cessation of therapy) was negative in 10 (77%) treated dogs; a negative follow-up culture was not associated with gender, age or duration of treatment. Bacteriuria persisted in three treated dogs and the one untreated dog. The prevalence of positive bacterial urinary culture in dogs with hypercortisolism was lower than previously reported. In the majority of dogs, bacteriuria was subclinical. Most dogs had a negative bacterial culture result after antimicrobial treatment; however, more resistant bacteria were detected in persistently positive urine. Hund mit Hyperkortisolismus neigen dazu eine Bakteriurie zu entwickeln, die entweder mit oder ohne klinische Anzeichen einer Blasenentzündung verbunden sein kann. Nach den aktuellen Behandlungsempfehlungen sollten Hunde mit subklinischer Bakteriurie nicht mit Antibiotika therapiert werden, da es keine Hinweise auf eine Verbesserung des Therapieerfolges gibt und unnötige Behandlungen vermieden werden sollten. Bevor diese Richtlinien im Jahr 2019 veröffentlicht wurden, wurden Hunde mit Hyperkortisolismus und Bakteriurie unabhängig von den klinischen Symptomen standardmässig mit Antibiotika behandelt. Daten zur Häufigkeit von bakteriellen Blasenentzündungen, subklinischer Bakteriurie und zum Ergebnis einer antimikrobiellen Behandlung bei Hunden mit Hyperkortisolismus liegen nur spärlich vor. Ziel dieser Studie war es, Hunde mit Hyperkortisolismus auf das Vorhandensein einer bakteriellen Blasenentzündung und subklinischen Bakteriurie zu untersuchen, die beteiligten Krankh...

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Treating canine Cushing’s syndrome: Current options and future prospects

Cited by 41 publications

References 119 publications

Síndrome de Cushing en un paciente canino con carcinoma cortical adrenal: Reporte de un caso

Síndrome de Cushing en un paciente canino con carcinoma cortical adrenal: Reporte de un caso

Vestibular dysfunction due to thalamic metastasis of a corticotropic carcinoma in a dog

Urinary tract infections in dogs with spontaneous hypercortisolism – frequency, symptoms and involved pathogens

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