Treating papillary and follicular thyroid cancer in children and young people: Single UK-center experience between 2003 and 2018

Jong, Mechteld C. de; Gaze, Mark; Szychot, Elwira; García, Virginia Rozalén; Brain, Caroline; Dattani, Mehul; Spoudeas, Helen; Hindmarsh, Peter C.; Abdel-Aziz, Tarek Ezzat; Bomanji, Jamshed; Shankar, Ananth; Stoneham, Sara; Morley, Simon; Beale, Tim; Jawad, Susan; Otero, Sofia; Proctor, Ian; Amin, Sepideh; Butler, Gary; Hewitt, Richard; Kurzawinski, Tom

doi:10.1016/j.jpedsurg.2020.07.034

Cited by 15 publications

(16 citation statements)

References 52 publications

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“…Mechteld et al. found a rate of hypocalcemia of 37.5%, with long-term hypoparathyroidism persisting in 18 patients (25.0%) ( 16 ). In a 21-year study of 184 PTC patients, transient and permanent hypoparathyroidism occurred in 33.1% and 3.3% of cases, respectively ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…Most studies report recurrence rates of 20% to 40% 10 years after initial treatment of the disease (5,(12)(13)(14)(15). Mechteld et al found that 72 children with DTC (<18 years) who were treated at a single institution between 2003 and 2018 had a median DFS time of 36.7 months, with a 1-year recurrence-free survival (RFS) rate of 93% and a 5-year RFS of 87% (16). A national multicenter retrospective review of 250 pediatric patients treated for PTC in Italy with an average follow-up of 5.8 years found that the rate of recurrent disease was 12% (30/250).…”

Section: Disease-free Survival and Prophylactic Cndmentioning

confidence: 99%

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Prophylactic Central Neck Dissection to Improve Disease-Free Survival in Pediatric Papillary Thyroid Cancer

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2022

Front. Oncol.

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BackgroundPediatric PTC is a rare disease. Although, the prognosis is excellent and the mortality rate is low, the role of prophylactic central neck dissection is still the subject of debate. The aim was to evaluate both the role and safety of prophylactic central neck dissection (CND) in managing pediatric papillary thyroid cancer (PTC), especially in respect of disease-free survival (DFS).Patients and MethodsIn this retrospective study, we collected 54 pediatric cN0 PTC patients (≤ 18 years of age) who were treated from January 2014 to January 2021 at a high-volume thyroid surgery center. Patients were divided into two groups based on the status of prophylactic CND. We analyzed the factors related to the clinicopathological features and recurrence of PTC in children.ResultsOf the 54 cN0 patients, 35 underwent prophylactic CND and 19 patients did not undergo prophylactic CND. The two groups were similar in clinical and pathologic features, such as age, gender, tumor size, multifocal status, and follow-up time. The average DFS was 84.4 ± 2.7 months. Log-rank tests on Kaplan-Meier curves revealed that age, gender, tumor size, multifocality, and extrathyroid extension did not relate to DFS time. Furthermore, DFS time was not affected by the extent of thyroidectomy (p=0.07) or RAI treatment (p=0.21). Prophylactic CND was found to increase DFS time for pediatric patients with cN0 PTC (p = 0.003). There was no statistically significant difference in complications such as transient hypocalcemia (p=0.15) and transient recurrent laryngeal nerve injury (p=0.37) between the prophylactic CND group and the no-prophylactic CND group.ConclusionProphylactic CND was found to be associated with increased DFS and not with increased rates of complications after surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Disease-free Survival and Prophylactic Cndmentioning

confidence: 99%

Prophylactic Central Neck Dissection to Improve Disease-Free Survival in Pediatric Papillary Thyroid Cancer

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2022

Front. Oncol.

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“…Compared to those of adults, pediatric thyroid cancers usually present with more advanced disease. Though the recurrence rates are higher than in adults, pediatric PTC has a better long-term outcome, with minimal or no mortality in most cases [54,57,58]. Pediatric PTC typically manifests as a palpable thyroid nodule/tumor, with or without cervical lymphadenopathy [59].…”

Section: Clinical Features Prognosis and Treatmentmentioning

confidence: 99%

Genetic Landscape of Papillary Thyroid Carcinoma and Nuclear Architecture: An Overview Comparing Pediatric and Adult Populations

Rangel‐Pozzo

Sisdelli

Cordioli

et al. 2020

Cancers

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Thyroid cancer is a rare malignancy in the pediatric population that is highly associated with disease aggressiveness and advanced disease stages when compared to adult population. The biological and molecular features underlying pediatric and adult thyroid cancer pathogenesis could be responsible for differences in the clinical presentation and prognosis. Despite this, the clinical assessment and treatments used in pediatric thyroid cancer are the same as those implemented for adults and specific personalized target treatments are not used in clinical practice. In this review, we focus on papillary thyroid carcinoma (PTC), which represents 80–90% of all differentiated thyroid carcinomas. PTC has a high rate of gene fusions and mutations, which can influence the histologic subtypes in both children and adults. This review also highlights telomere-related genomic instability and changes in nuclear organization as novel biomarkers for thyroid cancers.

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“…Papillary and follicular cancer of the thyroid gland occurs more commonly in adolescents than in younger children [1]. About eight patients under the age of 16 years are diagnosed annually in the UK.…”

Section: Differentiated Thyroid Cancermentioning

confidence: 99%

Paediatric Molecular Radiotherapy: Challenges and Opportunities

et al. 2021

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Treating papillary and follicular thyroid cancer in children and young people: Single UK-center experience between 2003 and 2018

Cited by 15 publications

References 52 publications

Prophylactic Central Neck Dissection to Improve Disease-Free Survival in Pediatric Papillary Thyroid Cancer

Prophylactic Central Neck Dissection to Improve Disease-Free Survival in Pediatric Papillary Thyroid Cancer

Genetic Landscape of Papillary Thyroid Carcinoma and Nuclear Architecture: An Overview Comparing Pediatric and Adult Populations

Paediatric Molecular Radiotherapy: Challenges and Opportunities

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